Revisiting maternal age and child health: A nationwide birth cohort study in Taiwan
Journal of the Formosan Medical Association,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Delayed
childbearing
is
a
growing
trend
globally,
with
Taiwan
experiencing
one
of
the
steepest
increases
in
maternal
age.
Advanced
age
affects
offspring
health,
including
birth
outcomes
and
long-term
morbidity.
However,
its
impact
remains
underexplored.
This
study
investigates
these
effects
using
nationwide
cohort.
retrospective
cohort
utilized
data
from
Taiwan's
National
Health
Insurance
Research
Database
(NHIRD),
covering
infants
born
January
1,
2004,
to
December
31,
2014.
The
included
2,068,672
infants,
categorized
into
six
groups:
<20,
20-24,
25-29,
30-34,
35-40,
≥40
years.
Principal
were
stillbirth,
mortality,
preterm
birth,
congenital
anomalies,
neurodevelopmental
outcomes,
atopic
diseases.
Multivariate
logistic
regression
models
adjusted
for
covariates
assess
associations
between
health
outcomes.
Among
stillbirth
mortality
rates
highest
mothers
<20
years,
decreased
increasing
age,
then
rose
again
≥30
showing
reverse
J-shaped
pattern.
Similar
trends
noted
Atopic
diseases
followed
nonlinear
trend,
peaking
at
25-34
Maternal
significantly
impacts
child
risks
associated
both
younger
older
ages.
These
findings
are
crucial
regions
delayed
childbearing.
Further
research
needed
explore
underlying
mechanisms
establish
causality.
Язык: Английский
Global, regional, and national burden of congenital musculoskeletal and limb anomalies, 1990–2021: a systematic analysis of the global burden of disease in 2021
Tropical Medicine and Health,
Год журнала:
2025,
Номер
53(1)
Опубликована: Май 12, 2025
Abstract
Background
Congenital
musculoskeletal
and
limb
(CML)
anomalies
are
uncommon,
multifactorial
conditions
whose
global
incidence
trends
remain
underexplored.
This
study
delineates
the
epidemiology
temporal
evolution
of
CML
from
1990
to
2021.
Methods
We
extracted
data
2021
burden
disease
(GBD)
Study,
stratifying
by
sex,
region,
country
socio-demographic
index
(SDI).
calculated
age-standardized
rate
(ASIR),
mortality
(ASMR),
prevalence
(ASPR),
estimated
annual
percentage
change
(EAPC).
Decomposition
analysis
quantified
contributions
population
growth,
aging,
epidemiological
change.
Projections
2031
were
made
using
an
autoregressive
integrated
moving
average
(ARIMA)
model.
Health
inequities
assessed
via
slope
inequality
(SII)
concentration
(CI).
Results
Global
patterns
exhibited
significant
disparities
between
Brunei
Darussalam
demonstrated
highest
ASIR,
while
Afghanistan
United
Mexican
States
recorded
ASMR
ASPR,
respectively.
Absolute
case
death
burdens
predominantly
clustered
in
populous
nations,
with
India
China
reporting
absolute
numbers.
ARIMA
modeling
projected
a
0.85%
increase
incident
cases
(from
2,437,890.12
2,458,596.45),
25.46%
decrease
13,599.83
10,137.02),
3.55%
18,549,408.27
19,207,414.19)
2031.
analyses
revealed
that
growth
was
primary
driver
increased
middle
SDI
regions,
whereas
transitions
aging
main
contributors
reductions.
In
lower-middle
concurrent
demographic
expansion
changes
amplified
burdens.
significantly
increased,
CI
rising
0.28
0.35
0.34
0.42
Significant
correlations
observed
EAPC
baseline
ASIR/ASMR,
declining
driven
transitions.
Conclusion
From
2021,
anomalies’
divergent
across
strata,
less
favorable
outcomes
lower-SDI
countries.
Tailored
interventions
essential
mitigate
growing
these
settings.
Язык: Английский
Diagnosis and treatment of gestational diabetes mellitus
Journal of Korean Medical Association,
Год журнала:
2024,
Номер
67(11), С. 686 - 694
Опубликована: Ноя. 10, 2024
Background:
The
increase
in
obesity
and
diabetes,
coupled
with
advanced
maternal
age,
has
led
to
an
pregnancies
affected
by
hyperglycemia,
including
gestational
diabetes
mellitus
(GDM),
pre-existing
early
pregnancy
hyperglycemia
that
does
not
meet
the
full
criteria
for
diabetes.
This
surge
necessitates
better
screening
management
practices
mitigate
associated
fetal
risks.Current
Concepts:
diagnosis
of
GDM
remains
challenging
owing
inconsistent
criteria,
such
as
differences
oral
glucose
tolerance
test
thresholds
various
strategies
diagnosing
managing
before
20
weeks
gestation.
Continuous
monitoring
emerged
a
promising
tool
allows
comprehensive
profile
tracking
without
timing
constraints.
Additionally,
digital
health
tools,
mobile
applications,
have
shown
potential
supporting
control
management.
These
technologies
may
enable
more
personalized
care
improve
compliance
lifestyle
modifications,
although
evidence
is
needed
establish
standardized
guidelines
their
application.Discussion
Conclusion:
Given
increasing
number
high-risk
pregnancies,
diagnostic
effective
protocols
are
urgently
needed.
Further
research
policy
initiatives
crucial
developing
prevention,
diagnosis,
GDM,
ultimately
reducing
its
progression
postpartum
type
2
Digital
can
be
used
improving
neonatal
outcomes,
ensuring
long-term
mothers
offspring.
Язык: Английский