World Journal of Stem Cells, Год журнала: 2025, Номер 17(5)
Опубликована: Май 23, 2025
Ankylosing spondylitis (AS) is a chronic, progressive, systemic autoimmune disease characterised by spinal stiffness and ocular, cardiac, intestinal, peripheral joint involvements. Genetics, infectious agents, immune-mediated inflammatory processes have all been hypothesized to contribute AS pathogenesis, but the precise aetiology remains elusive. Recent studies identified biological cellular factors that correlate with onset progression of AS. This has provided avenues research may help elucidate mechanisms lead advances in therapeutic interventions. study aimed examine some findings from recent molecular studies, focusing on mechanism associated such as interleukin-17, tumor necrosis factor-alpha, receptor activator nuclear factor-kappa B/receptor B ligand/osteoprotegerin pathway, related microRNAs gain insight into aberrant bone formation potential approaches its prevention. editorial also addresses contribution osteoclasts pathology The author examined pathways governing osteoclast differentiation activity, particular emphasis relevant cytokines immune cell interactions. A comprehensive understanding these essential for development targeted therapies mitigate excessive resorption pathological skeletal remodeling
Язык: Английский