Mitigation of Insulin Resistance, Inflammation, Oxidative Stress, and Metabolic Abnormalities by Bavachalcone in High-Fat/High-Fructose Diet-Fed Rats DOI Creative Commons
Jie Yin

Indian Journal of Pharmaceutical Education and Research, Год журнала: 2025, Номер 59(1), С. 134 - 143

Опубликована: Янв. 6, 2025

Background Obesity is defined by an excess of body fat, together with insulin resistance and dyslipidemia. These factors significantly elevate the risk acquiring chronic disorders such as Diabetes Mellitus (DM), cardiovascular diseases, neurological disorders, etc. Objectives The goal current study was to evaluate bavachalcone's beneficial effects on obesity in experimental rats fed a High-Fat High-Fructose (HFa-HFr) diet. Materials Methods metabolic complications were induced HFa-HFr diet feeding for period 10 weeks treated bavachalcone from 5th 10th weeks. various parameters food water consumption, weight, insulin, blood glucose level, serum biochemical markers, liver oxidative stress proinflammatory cytokine levels assessed after treatment. Additionally, histopathological examination conducted tissues. Results findings showed that exhibited notable elevation glucose, fat deposits, marker enzyme activities. changes effectively mitigated Furthermore, resulted elevated accumulation, stress, inflammatory biomarker levels. In contrast, treatment successfully reduced resistance, deposition, inflammatory, conditions diet-fed rats. Conclusion results clearly diet-caused abnormalities reducing deposition markers. Keywords: Metabolic syndrome, Fatty liver, Bavachalcone, Insulin Inflammation

Язык: Английский

Mitigation of Insulin Resistance, Inflammation, Oxidative Stress, and Metabolic Abnormalities by Bavachalcone in High-Fat/High-Fructose Diet-Fed Rats DOI Creative Commons
Jie Yin

Indian Journal of Pharmaceutical Education and Research, Год журнала: 2025, Номер 59(1), С. 134 - 143

Опубликована: Янв. 6, 2025

Background Obesity is defined by an excess of body fat, together with insulin resistance and dyslipidemia. These factors significantly elevate the risk acquiring chronic disorders such as Diabetes Mellitus (DM), cardiovascular diseases, neurological disorders, etc. Objectives The goal current study was to evaluate bavachalcone's beneficial effects on obesity in experimental rats fed a High-Fat High-Fructose (HFa-HFr) diet. Materials Methods metabolic complications were induced HFa-HFr diet feeding for period 10 weeks treated bavachalcone from 5th 10th weeks. various parameters food water consumption, weight, insulin, blood glucose level, serum biochemical markers, liver oxidative stress proinflammatory cytokine levels assessed after treatment. Additionally, histopathological examination conducted tissues. Results findings showed that exhibited notable elevation glucose, fat deposits, marker enzyme activities. changes effectively mitigated Furthermore, resulted elevated accumulation, stress, inflammatory biomarker levels. In contrast, treatment successfully reduced resistance, deposition, inflammatory, conditions diet-fed rats. Conclusion results clearly diet-caused abnormalities reducing deposition markers. Keywords: Metabolic syndrome, Fatty liver, Bavachalcone, Insulin Inflammation

Язык: Английский

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