Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study

European Heart Journal, Год журнала: 2021, Номер 42(42), С. 4324 - 4332

Опубликована: Июнь 23, 2021

Emerging evidence suggests that remnant cholesterol (RC) promotes atherosclerotic cardiovascular disease (ASCVD). We aimed to estimate RC-related risk beyond low-density lipoprotein (LDL-C) and apolipoprotein B (apoB) in patients without known ASCVD.

Язык: Английский

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PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

Archives of Medical Science, Год журнала: 2021, Номер 17(6), С. 1447 - 1547

Опубликована: Ноя. 9, 2021

In Poland there are still nearly 20 million individuals with hypercholesterolaemia, most of them unaware their condition; that is also why only ca. 5% patients familial hypercholesterolaemia have been diagnosed; other rare cholesterol metabolism disorders so rarely diagnosed in Poland. Let us hope these guidelines, being an effect work experts representing 6 main scientific societies, as well the network PoLA lipid centers a part EAS centers, certification lipidologists by PoLA, or growing number for diseases, planned Ministry Health, improvements coordinated care after myocardial infarction (KOS-Zawał), reimbursement innovative agents, introduction effective primary prevention program, will make improvement relation to unmet needs diagnostics and treatment possible.

Язык: Английский

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Comparison of Low-Density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation

JAMA Cardiology, Год журнала: 2018, Номер 3(8), С. 749 - 749

Опубликована: Июнь 13, 2018

Recent studies have shown that Friedewald underestimates low-density lipoprotein cholesterol (LDL-C) at lower levels, which could result in undertreatment of high-risk patients. A novel method (Martin/Hopkins) using a patient-specific conversion factor provides more accurate LDL-C levels. However, this has not been tested proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor-treated patients.To investigate accuracy 2 different methods for estimating levels (Martin/Hopkins and Friedewald) compared with gold standard preparative ultracentrifugation (PUC) patients low the Further Cardiovascular Outcomes Research With PCSK9 Inhibition Patients Elevated Risk (FOURIER) trial.The FOURIER trial was randomized clinical evolocumab vs placebo added to statin therapy 27 564 stable atherosclerotic cardiovascular disease. The patients' were assessed baseline, 4 weeks, 12 24 every weeks thereafter, measured directly by PUC when level less than 40 mg/dL per (calculated as non-HDL-C - triglycerides/5). In Martin/Hopkins method, ratios triglycerides very (VLDL-C) determined used estimate VLDL-C, subtracted from obtain level.Low-density calculated methods, reference method.For analysis, mean (SD) age 62.7 (9.0) years; 2885 742 women (22.6%). total 56 624 observations had Friedewald, Martin/Hopkins, measurements. median difference -2 (interquartile range [IQR], -4 1 mg/dL) (IQR, -8 -1 mg/dL; P < .001). Overall, 22.9% values 5 values, 2.6% 10 These significantly respective proportions estimation (40.1% 13.3%; .001), mainly because underestimation method. correlation higher (ρ, 0.918 [95% CI 0.916-0.919] ρ, 0.867 [0.865-0.869], .001).In achieving inhibition, closely approximates does. may prevent method.ClinicalTrials.gov Identifier: NCT01764633.

Язык: Английский

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Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels

JAMA Network Open, Год журнала: 2021, Номер 4(10), С. e2128817 - e2128817

Опубликована: Окт. 28, 2021

Importance

Low-density lipoprotein cholesterol (LDL-C) is typically estimated with the Friedewald or Martin/Hopkins equation; however, if triglyceride levels are 400 mg/dL greater, laboratories reflexively perform direct LDL-C (dLDL-C) measurement. The use of chemical assays and estimation via National Institutes Health Sampson equation not well validated, data on accuracy at higher limited.

Objective

To compare an extended for values to 799 equations.

Design, Setting, Participants

This cross-sectional study evaluated consecutive patients clinical sites across US patient lipid distributions representative population in Very Large Database Lipids from January 1, 2006, December 31, 2015, mg/dL. Data analysis was performed November 9, 2020, March 23, 2021.

Main Outcomes Measures

Accuracy classification according guideline-based categories absolute errors between dLDL-C levels. Patients were randomly assigned 2:1 derivation validation sets. Levels measured by vertical spin-density gradient ultracentrifugation. using method, a fixed ratio triglycerides very low-density (VLDL-C 5:1), flexible ratio, VLDL-C multiple least-squares regression.

Results

A total 111 939 (mean [SD] age, 52 [13] years; 65.0% male) included, representing 2.2% 5 081 680 database. Across all individual guideline classes (<40, 40-69, 70-99, 100-129, 130-159, 160-189, ≥190), most accurate (62.1%) compared (19.3%) (40.4%) In classifying less than 70 strata, (67.3%) (5.1%) (26.4%) addition, 40 (57.2%) (4.3%) (14.4%) However, considerable underclassification occurred. magnitude error also smaller: mg/dL, 2.7% had 30 greater differences (92.5%) (38.7%)

Conclusions Relevance

this study, offered equations regardless method used, caution advised range.

Язык: Английский

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2020 Guidelines of the Polish Society of Laboratory Diagnostics (PSLD) and the Polish Lipid Association (PoLA) on laboratory diagnostics of lipid metabolism disorders

Archives of Medical Science, Год журнала: 2020, Номер 16(2), С. 237 - 252

Опубликована: Янв. 1, 2020

1. Banach M, Jankowski P, Jóżwiak J, et al. (2017). PoLA/CFPiP/PCS guidelines for the management of dyslipidaemias family physicians 2016 Arch Med Sci. 13: 1-45. Google Scholar

Язык: Английский

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Accuracy of 23 Equations for Estimating LDL Cholesterol in a Clinical Laboratory Database of 5,051,467 Patients

Global Heart, Год журнала: 2023, Номер 18(1), С. 36 - 36

Опубликована: Июнь 19, 2023

Background: Alternatives to the Friedewald low-density lipoprotein cholesterol (LDL-C) equation have been proposed. Objective: To compare accuracy of available LDL-C equations with ultracentrifugation measurement. Methods: We used second harvest Very Large Database Lipids (VLDbL), which is a population-representative convenience sample adult and pediatric patients (N = 5,051,467) clinical lipid measurements obtained via vertical auto profile (VAP) method between October 1, 2015 June 30, 2019. performed systematic literature review identify compared their according guideline-based classification. also by median error versus ultracentrifugation. evaluated overall stratified age, sex, fasting status, triglyceride levels, as well in atherosclerotic cardiovascular disease, hypertension, diabetes, kidney inflammation, thyroid dysfunction. Results: Analyzing 23 identified 5,051,467 (mean±SD 56±16 years; 53.3% women), Martin/Hopkins most accurately classified correct category (89.6%), followed Sampson (86.3%), Chen (84.4%), Puavilai (84.1%), Delong (83.3%), (83.2%) equations. The other 17 were less accurate than Friedewald, low 35.1%. ranged from –10.8 18.7 mg/dL, was best optimized using (0.3, IQR–1.6 2.4 mg/dL). had highest after stratifying subgroups. In addition, one five who <70 almost half mg/dL levels 150–399 correctly reclassified >70 equation. Conclusions: Most proposed alternatives worsen accuracy, use could introduce unintended disparities care. demonstrated across

Язык: Английский

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2024 Guidelines of the Polish Society of Laboratory Diagnostics and the Polish Lipid Association on laboratory diagnostics of lipid metabolism disorders.

Archives of Medical Science, Год журнала: 2024, Номер unknown

Опубликована: Март 18, 2024

Lipid disorders are the most common (even 70%) and worst monitored cardiovascular risk factor (only 1/4 of patients in Poland CEE countries on LDL-C goal). In order to improve this clear easy implement diagnostic criteria for all components lipid profile should be introduced. These updated guidelines two main scientific societies area - Polish Society Laboratory Diagnostics (PSLD) Association (PoLA), which, comparison those from 2020, introduce few important changes recommendations (two targets, new measurement, goals triglycerides, remnants sdLDL) that help practitioners early with diagnosis monitoring (after therapy initiation), consequence avoid first recurrent events.

Язык: Английский

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Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State

Journal of Atherosclerosis and Thrombosis, Год журнала: 2017, Номер 24(6), С. 583 - 599

Опубликована: Янв. 1, 2017

Aim: Most epidemiological and clinical studies calculated low-density lipoprotein-cholesterol (LDL-C) by Friedewald's formula which cannot be used in the postprandial samples.Although homogeneous assays with poor analytical performance were withdrawn from market, it remained unclear whether currently available reagents for LDL-C high-density (HDL-C) are as accurate samples fasting samples.Methods: Fresh blood collected 59 non-diseased 109 diseased subjects.Postprandial constituted 72.9% 39.4% of these samples.LDL-C HDL-C concentrations measured using four manufacturers (Denka Seiken, Wako, Kyowa Medex, Sekisui Medical).Simultaneously, determined reference measurement procedures (RMPs) Centers Disease Control Prevention (CDC).Total errors a routine method (TEcom) via error component analysis (TEECA).Results: All met National Cholesterol Education Program (NCEP) requirements terms coefficient variation, TEcom both subjects.LDL-C values good agreement those RMPs samples.The TEECA similar to samples, although up 4.4-fold greater than values.Conclusions: In subjects, samples.

Язык: Английский

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More accurate LDL-C calculation: Externally validated, guideline endorsed

Clinica Chimica Acta, Год журнала: 2020, Номер 506, С. 149 - 153

Опубликована: Март 20, 2020

Язык: Английский

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Validation of Friedewald, Martin-Hopkins and Sampson low-density lipoprotein cholesterol equations

PLoS ONE, Год журнала: 2022, Номер 17(5), С. e0263860 - e0263860

Опубликована: Май 13, 2022

Background Low-density lipoprotein cholesterol (LDL-C) is an important biomarker for determining cardiovascular risk and regulating lipid lowering therapy. Therefore, the accurate estimation of LDL-C concentration essential in disease diagnosis prognosis. Sampson recently proposed a new formula LDL-C. However, little known regarding validation this formula. Objectives This study aimed to validate with other well-known formulas Turkish population, composed adults. Methods A total 88,943 participants above 18 years old at Sivas Cumhuriyet University Hospital (Sivas, Turkey) were included study. was directly measured by homogeneous assays, i.e., Roche, Beckman Siemens estimated Friedewald’s, Martin-Hopkins’, extended Martin-Hopkins’ Sampson’s formulas. The concordances between estimations obtained direct measurements evaluated both general separately LDL-C, TG non-HDL-C sublevels. Linear regression analysis applied residual error plots generated each measurement method. Coefficient determination ( R 2 ) mean absolute deviations also calculated. Results results showed that Martin-Hopkins approach provided most concordant assays estimation. highest calculated median statistics from our own population. On hand, it observed methods may differ different assays. approach, gave patients “low level (LDL-C levels < 70 mg/dL) or hypertriglyceridemia (TG ≥ 400 mg/dL)”. Conclusions Although vary, best one overall concordances. validity Martin Hopkins’ has be further investigated populations.

Язык: Английский

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