Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(10), С. 3570 - 3570
Опубликована: Май 20, 2023
Low-density
lipoprotein
cholesterol
(LDL-C)
is
a
well-established
biomarker
in
the
management
of
dyslipidemia.
Therefore,
we
aimed
to
evaluate
concordance
LDL-C-estimating
equations
with
direct
enzymatic
measurement
diabetic
and
prediabetic
populations.
The
data
31,031
subjects
included
study
were
divided
into
prediabetic,
diabetic,
control
groups
according
HbA1c
values.
LDL-C
was
measured
by
homogenous
assay
calculated
Martin-Hopkins,
Martin-Hopkins
extended,
Friedewald,
Sampson
equations.
statistics
between
measurements
estimations
obtained
evaluated.
All
evaluated
had
lower
compared
non-diabetic
group.
Even
so,
extended
approach
demonstrated
highest
statistic
patients.
Further,
found
have
correlation
other
Over
190
mg/dL
concentrations,
equation
again
extended.
In
most
scenarios,
performed
best
groups.
Additionally,
methods
can
be
used
at
low
values
non-HDL-C/TG
ratio
(<2.4),
as
performance
estimation
decreases
decreases.
European Heart Journal,
Год журнала:
2021,
Номер
42(42), С. 4324 - 4332
Опубликована: Июнь 23, 2021
Emerging
evidence
suggests
that
remnant
cholesterol
(RC)
promotes
atherosclerotic
cardiovascular
disease
(ASCVD).
We
aimed
to
estimate
RC-related
risk
beyond
low-density
lipoprotein
(LDL-C)
and
apolipoprotein
B
(apoB)
in
patients
without
known
ASCVD.
Archives of Medical Science,
Год журнала:
2021,
Номер
17(6), С. 1447 - 1547
Опубликована: Ноя. 9, 2021
In
Poland
there
are
still
nearly
20
million
individuals
with
hypercholesterolaemia,
most
of
them
unaware
their
condition;
that
is
also
why
only
ca.
5%
patients
familial
hypercholesterolaemia
have
been
diagnosed;
other
rare
cholesterol
metabolism
disorders
so
rarely
diagnosed
in
Poland.
Let
us
hope
these
guidelines,
being
an
effect
work
experts
representing
6
main
scientific
societies,
as
well
the
network
PoLA
lipid
centers
a
part
EAS
centers,
certification
lipidologists
by
PoLA,
or
growing
number
for
diseases,
planned
Ministry
Health,
improvements
coordinated
care
after
myocardial
infarction
(KOS-Zawał),
reimbursement
innovative
agents,
introduction
effective
primary
prevention
program,
will
make
improvement
relation
to
unmet
needs
diagnostics
and
treatment
possible.
JAMA Cardiology,
Год журнала:
2018,
Номер
3(8), С. 749 - 749
Опубликована: Июнь 13, 2018
Recent
studies
have
shown
that
Friedewald
underestimates
low-density
lipoprotein
cholesterol
(LDL-C)
at
lower
levels,
which
could
result
in
undertreatment
of
high-risk
patients.
A
novel
method
(Martin/Hopkins)
using
a
patient-specific
conversion
factor
provides
more
accurate
LDL-C
levels.
However,
this
has
not
been
tested
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
inhibitor-treated
patients.To
investigate
accuracy
2
different
methods
for
estimating
levels
(Martin/Hopkins
and
Friedewald)
compared
with
gold
standard
preparative
ultracentrifugation
(PUC)
patients
low
the
Further
Cardiovascular
Outcomes
Research
With
PCSK9
Inhibition
Patients
Elevated
Risk
(FOURIER)
trial.The
FOURIER
trial
was
randomized
clinical
evolocumab
vs
placebo
added
to
statin
therapy
27
564
stable
atherosclerotic
cardiovascular
disease.
The
patients'
were
assessed
baseline,
4
weeks,
12
24
every
weeks
thereafter,
measured
directly
by
PUC
when
level
less
than
40
mg/dL
per
(calculated
as
non-HDL-C
-
triglycerides/5).
In
Martin/Hopkins
method,
ratios
triglycerides
very
(VLDL-C)
determined
used
estimate
VLDL-C,
subtracted
from
obtain
level.Low-density
calculated
methods,
reference
method.For
analysis,
mean
(SD)
age
62.7
(9.0)
years;
2885
742
women
(22.6%).
total
56
624
observations
had
Friedewald,
Martin/Hopkins,
measurements.
median
difference
-2
(interquartile
range
[IQR],
-4
1
mg/dL)
(IQR,
-8
-1
mg/dL;
P
<
.001).
Overall,
22.9%
values
5
values,
2.6%
10
These
significantly
respective
proportions
estimation
(40.1%
13.3%;
.001),
mainly
because
underestimation
method.
correlation
higher
(ρ,
0.918
[95%
CI
0.916-0.919]
ρ,
0.867
[0.865-0.869],
.001).In
achieving
inhibition,
closely
approximates
does.
may
prevent
method.ClinicalTrials.gov
Identifier:
NCT01764633.
JAMA Network Open,
Год журнала:
2021,
Номер
4(10), С. e2128817 - e2128817
Опубликована: Окт. 28, 2021
Importance
Low-density
lipoprotein
cholesterol
(LDL-C)
is
typically
estimated
with
the
Friedewald
or
Martin/Hopkins
equation;
however,
if
triglyceride
levels
are
400
mg/dL
greater,
laboratories
reflexively
perform
direct
LDL-C
(dLDL-C)
measurement.
The
use
of
chemical
assays
and
estimation
via
National
Institutes
Health
Sampson
equation
not
well
validated,
data
on
accuracy
at
higher
limited.
Objective
To
compare
an
extended
for
values
to
799
equations.
Design,
Setting,
Participants
This
cross-sectional
study
evaluated
consecutive
patients
clinical
sites
across
US
patient
lipid
distributions
representative
population
in
Very
Large
Database
Lipids
from
January
1,
2006,
December
31,
2015,
mg/dL.
Data
analysis
was
performed
November
9,
2020,
March
23,
2021.
Main
Outcomes
Measures
Accuracy
classification
according
guideline-based
categories
absolute
errors
between
dLDL-C
levels.
Patients
were
randomly
assigned
2:1
derivation
validation
sets.
Levels
measured
by
vertical
spin-density
gradient
ultracentrifugation.
using
method,
a
fixed
ratio
triglycerides
very
low-density
(VLDL-C
5:1),
flexible
ratio,
VLDL-C
multiple
least-squares
regression.
Results
A
total
111
939
(mean
[SD]
age,
52
[13]
years;
65.0%
male)
included,
representing
2.2%
5
081
680
database.
Across
all
individual
guideline
classes
(<40,
40-69,
70-99,
100-129,
130-159,
160-189,
≥190),
most
accurate
(62.1%)
compared
(19.3%)
(40.4%)
In
classifying
less
than
70
strata,
(67.3%)
(5.1%)
(26.4%)
addition,
40
(57.2%)
(4.3%)
(14.4%)
However,
considerable
underclassification
occurred.
magnitude
error
also
smaller:
mg/dL,
2.7%
had
30
greater
differences
(92.5%)
(38.7%)
Conclusions
Relevance
this
study,
offered
equations
regardless
method
used,
caution
advised
range.
Archives of Medical Science,
Год журнала:
2020,
Номер
16(2), С. 237 - 252
Опубликована: Янв. 1, 2020
1.
Banach
M,
Jankowski
P,
Jóżwiak
J,
et
al.
(2017).
PoLA/CFPiP/PCS
guidelines
for
the
management
of
dyslipidaemias
family
physicians
2016
Arch
Med
Sci.
13:
1-45.
Google
Scholar
Global Heart,
Год журнала:
2023,
Номер
18(1), С. 36 - 36
Опубликована: Июнь 19, 2023
Background:
Alternatives
to
the
Friedewald
low-density
lipoprotein
cholesterol
(LDL-C)
equation
have
been
proposed.
Objective:
To
compare
accuracy
of
available
LDL-C
equations
with
ultracentrifugation
measurement.
Methods:
We
used
second
harvest
Very
Large
Database
Lipids
(VLDbL),
which
is
a
population-representative
convenience
sample
adult
and
pediatric
patients
(N
=
5,051,467)
clinical
lipid
measurements
obtained
via
vertical
auto
profile
(VAP)
method
between
October
1,
2015
June
30,
2019.
performed
systematic
literature
review
identify
compared
their
according
guideline-based
classification.
also
by
median
error
versus
ultracentrifugation.
evaluated
overall
stratified
age,
sex,
fasting
status,
triglyceride
levels,
as
well
in
atherosclerotic
cardiovascular
disease,
hypertension,
diabetes,
kidney
inflammation,
thyroid
dysfunction.
Results:
Analyzing
23
identified
5,051,467
(mean±SD
56±16
years;
53.3%
women),
Martin/Hopkins
most
accurately
classified
correct
category
(89.6%),
followed
Sampson
(86.3%),
Chen
(84.4%),
Puavilai
(84.1%),
Delong
(83.3%),
(83.2%)
equations.
The
other
17
were
less
accurate
than
Friedewald,
low
35.1%.
ranged
from
–10.8
18.7
mg/dL,
was
best
optimized
using
(0.3,
IQR–1.6
2.4
mg/dL).
had
highest
after
stratifying
subgroups.
In
addition,
one
five
who
<70
almost
half
mg/dL
levels
150–399
correctly
reclassified
>70
equation.
Conclusions:
Most
proposed
alternatives
worsen
accuracy,
use
could
introduce
unintended
disparities
care.
demonstrated
across
Archives of Medical Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 18, 2024
Lipid
disorders
are
the
most
common
(even
70%)
and
worst
monitored
cardiovascular
risk
factor
(only
1/4
of
patients
in
Poland
CEE
countries
on
LDL-C
goal).
In
order
to
improve
this
clear
easy
implement
diagnostic
criteria
for
all
components
lipid
profile
should
be
introduced.
These
updated
guidelines
two
main
scientific
societies
area
-
Polish
Society
Laboratory
Diagnostics
(PSLD)
Association
(PoLA),
which,
comparison
those
from
2020,
introduce
few
important
changes
recommendations
(two
targets,
new
measurement,
goals
triglycerides,
remnants
sdLDL)
that
help
practitioners
early
with
diagnosis
monitoring
(after
therapy
initiation),
consequence
avoid
first
recurrent
events.
Journal of Atherosclerosis and Thrombosis,
Год журнала:
2017,
Номер
24(6), С. 583 - 599
Опубликована: Янв. 1, 2017
Aim:
Most
epidemiological
and
clinical
studies
calculated
low-density
lipoprotein-cholesterol
(LDL-C)
by
Friedewald's
formula
which
cannot
be
used
in
the
postprandial
samples.Although
homogeneous
assays
with
poor
analytical
performance
were
withdrawn
from
market,
it
remained
unclear
whether
currently
available
reagents
for
LDL-C
high-density
(HDL-C)
are
as
accurate
samples
fasting
samples.Methods:
Fresh
blood
collected
59
non-diseased
109
diseased
subjects.Postprandial
constituted
72.9%
39.4%
of
these
samples.LDL-C
HDL-C
concentrations
measured
using
four
manufacturers
(Denka
Seiken,
Wako,
Kyowa
Medex,
Sekisui
Medical).Simultaneously,
determined
reference
measurement
procedures
(RMPs)
Centers
Disease
Control
Prevention
(CDC).Total
errors
a
routine
method
(TEcom)
via
error
component
analysis
(TEECA).Results:
All
met
National
Cholesterol
Education
Program
(NCEP)
requirements
terms
coefficient
variation,
TEcom
both
subjects.LDL-C
values
good
agreement
those
RMPs
samples.The
TEECA
similar
to
samples,
although
up
4.4-fold
greater
than
values.Conclusions:
In
subjects,
samples.
PLoS ONE,
Год журнала:
2022,
Номер
17(5), С. e0263860 - e0263860
Опубликована: Май 13, 2022
Background
Low-density
lipoprotein
cholesterol
(LDL-C)
is
an
important
biomarker
for
determining
cardiovascular
risk
and
regulating
lipid
lowering
therapy.
Therefore,
the
accurate
estimation
of
LDL-C
concentration
essential
in
disease
diagnosis
prognosis.
Sampson
recently
proposed
a
new
formula
LDL-C.
However,
little
known
regarding
validation
this
formula.
Objectives
This
study
aimed
to
validate
with
other
well-known
formulas
Turkish
population,
composed
adults.
Methods
A
total
88,943
participants
above
18
years
old
at
Sivas
Cumhuriyet
University
Hospital
(Sivas,
Turkey)
were
included
study.
was
directly
measured
by
homogeneous
assays,
i.e.,
Roche,
Beckman
Siemens
estimated
Friedewald’s,
Martin-Hopkins’,
extended
Martin-Hopkins’
Sampson’s
formulas.
The
concordances
between
estimations
obtained
direct
measurements
evaluated
both
general
separately
LDL-C,
TG
non-HDL-C
sublevels.
Linear
regression
analysis
applied
residual
error
plots
generated
each
measurement
method.
Coefficient
determination
(
R
2
)
mean
absolute
deviations
also
calculated.
Results
results
showed
that
Martin-Hopkins
approach
provided
most
concordant
assays
estimation.
highest
calculated
median
statistics
from
our
own
population.
On
hand,
it
observed
methods
may
differ
different
assays.
approach,
gave
patients
“low
level
(LDL-C
levels
<
70
mg/dL)
or
hypertriglyceridemia
(TG
≥
400
mg/dL)”.
Conclusions
Although
vary,
best
one
overall
concordances.
validity
Martin
Hopkins’
has
be
further
investigated
populations.