Comparing a novel machine learning method to the Friedewald formula and Martin-Hopkins equation for low-density lipoprotein estimation

PLoS ONE, Год журнала: 2020, Номер 15(9), С. e0239934 - e0239934

Опубликована: Сен. 30, 2020

Background Low-density lipoprotein cholesterol (LDL-C) is a target for cardiovascular prevention. Contemporary equations LDL-C estimation have limited accuracy in certain scenarios (high triglycerides [TG], very low LDL-C). Objectives We derived novel method from the standard lipid profile using machine learning (ML) approach utilizing random forests (the Weill Cornell model). compared its correlation to direct with Friedewald and Martin-Hopkins estimation. Methods The study cohort comprised convenience sample of measurements (with directly measured components total [TC], high-density [HDL-C], TG) as well chemical-based performed on same day at New York-Presbyterian Hospital/Weill Medicine (NYP-WCM). Subsequently, an ML algorithm was used construct model Results are reported held-out test set, coefficients absolute residuals assess performance. Between 2005 2019, there were 17,500 profiles 10,936 unique individuals (4,456 females; 40.8%) aged 1 103. Correlation between estimated values 0.982 model, 0.950 0.962 method. consistently better across subgroups stratified by TG values, including >500 <70. Conclusions An found than either formula or equation, setting elevated LDL-C.

Язык: Английский

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2021 PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on the diagnosis and therapy of lipid disorders in Poland

Diagnostyka Laboratoryjna, Год журнала: 2021, Номер 57(1), С. 1 - 99

Опубликована: Ноя. 3, 2021

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Health camps for truck drivers: a community-based approach to wellness

International Journal of Community Medicine and Public Health, Год журнала: 2025, Номер 12(6), С. 2613 - 2620

Опубликована: Май 31, 2025

Background: Globally, non-communicable diseases (NCDs) are a leading cause of morbidity and mortality. Occupational lifestyle, particularly in professions like truck driving, increases exposure to NCD risk factors. Early detection at the community level is vital for prevention ensuring well-being. M/S Primary Healthtech Private Limited, collaboration with Indian Institute Technology Guwahati, developed “Mobilab” portable, battery-operated, IoT-enabled biochemistry analyzer. To support early screening, health camps targeting drivers key contributors national supply chain were conducted. Methods: Two organized Binola (Camp-1) Greater Noida (Camp-2), screening 382 234 participants respectively over 8 days each. Screening used Mobilab device assess various biochemical physiological parameters NCDs. Results: Parameters tested included cholesterol (CHOL), triglyceride (TGL), LDL, HDL, uric acid (UA), creatinine (CRE), glucose (GLU), hemoglobin (HB), total bilirubin (TBIL), protein (TP), albumin (ALB), globulin (GLO), albumin/globulin ratio (A/G). Camp-2 showed higher prevalence kidney issues (41.1%) anemia (39%) compared Camp-1 (26.18% 18%, respectively). Diabetes was low both camps: 2.88% 2.16% Camp-2. Conclusions: This community-based among highlights effectiveness using portable diagnostic tools. The study underscores importance regular check-ups, especially kidney-related complications, need sustained preventive healthcare initiatives high-risk occupational groups.

Язык: Английский

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Comparison of Novel Equations for Estimating Low-Density Lipoprotein Cholesterol in Patients Undergoing Coronary Angiography

Journal of Atherosclerosis and Thrombosis, Год журнала: 2020, Номер 27(12), С. 1359 - 1373

Опубликована: Июль 1, 2020

The importance of precisely quantifying low-density lipoprotein cholesterol (LDL-C) has become more pronounced over the years, with rise metabolic syndrome in population and reduction LDL-C treatment goals. This study aims to compare two novel equations indirectly estimating assess their compatibility Friedewald formula, a high cardiovascular risk.This is retrospective analysis lipid profiles 10,006 patients who underwent coronary angiography. was calculated using Friedewald, Martin, Sampson equations, between estimations compared methods concordance reclassification.Our findings show that Martin displayed rates upward reclassification (10.8% 7.5%, respectively) when equation. In comparison method, also reclassified 3.8 % higher category. magnitude discordance estimates hypertriglyceridemic patients, this increased progressively LDL-C. proportion ＜70 mg/dL category reached 44% (Sampson vs. Friedewald), 65% (Martin 37% vs.Sampson) those triglyceride levels 200 399 mg/dL.Both significant categories particularly elevated triglycerides low LDL-C, whom accurate estimation required. Further studies are warranted validate recently developed equation method tended significantly overestimate

Язык: Английский

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Estimation of low-density lipoprotein cholesterol by machine learning methods

Clinica Chimica Acta, Год журнала: 2021, Номер 517, С. 108 - 116

Опубликована: Март 2, 2021

Язык: Английский

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Comparison of low-density lipoprotein cholesterol equations in patients with dyslipidaemia receiving cholesterol ester transfer protein inhibition

European Heart Journal - Cardiovascular Pharmacotherapy, Год журнала: 2022, Номер 9(2), С. 148 - 155

Опубликована: Окт. 25, 2022

Low-density lipoprotein (LDL-C) lowering is imperative in cardiovascular disease prevention. We aimed to compare accuracy of three clinically-implemented LDL-C equations a clinical trial cholesterol ester transfer protein (CETP) inhibition.Men and women aged 18-75 years with dyslipidaemia were recruited from 17 sites the Netherlands Denmark. Patients randomly assigned one nine groups using various combinations CETP inhibitor TA-8995 (obicetrapib), statin therapy, placebo. In pooled measurements over 12 weeks, we calculated by Friedewald, Martin/Hopkins, Sampson equations, compared values preparative ultracentrifugation (PUC) overall special interest low LDL-C/high triglycerides subgroup. There 242 patients contributing 921 observations. Overall median differences between estimates PUC small: 0.00 (25th, 75th: -0.10, 0.08) mmol/L [0 (-4, 3) mg/dL]; 0.02 (-0.08, 0.10) [1 (-3, 4) Sampson, 0.05 (-0.03, 0.15) [2 (-1, 6) mg/dL]. subgroup estimated <1.8 (<70 mg/dL) 1.7-4.5 (150-399 mg/dL), Friedewald equation underestimated difference versus -0.25 (-0.33, -0.10) [-10 (-13, -4) mg/dL], whereas Martin/Hopkins was mg/dL] -0.06 (-0.13, 0.00) [-2 (-5, 0) this subgroup, proportion observations that correctly classified 71.4% vs. 100.0% 93.1% Sampson.In European receiving inhibitor, found improved contemporary equation, greatest observed equation.ClinicalTrials.gov, NCT01970215.

Язык: Английский

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Validity of a Novel Method for Estimating Low-Density Lipoprotein Cholesterol Levels in Cardiovascular Disease Patients Treated with Statins

Journal of Atherosclerosis and Thrombosis, Год журнала: 2018, Номер 25(7), С. 643 - 652

Опубликована: Май 22, 2018

The Friedewald equation is the standard method for estimating low-density lipoprotein cholesterol (LDL-C) levels [LDL-C(F)] and fixes ratio of triglyceride (TG) to very LDL-C at 5. However, this has been reported underestimate LDL-C, particularly in patients with ＜70 mg/dL. A novel estimation [LDL-C(M)] using an adjustable factor instead a fixed value 5 recently proposed. purpose study was validate LDL-C(M) Japanese cardiovascular disease (CVD) treated statins.In 385 consecutive CVD statins, LDL-C(F) were compared directly measured [LDL-C(D)].Mean LDL-C(D), LDL-C(F), 81.7±25.5, 76.4±24.6, 79.9±24.5 mg/dL, respectively. In all patients, both significantly correlated LDL-C(D) [LDL-C(F) vs. LDL-C(D): R=0.974, p＜0.001; R=0.987, p＜0.001]. showed better correlation LDLC(D) [LDL-C(M) R=0.935, LDLC(D): R=0.868, contrast, or similar ≥70 mg/dL.In level estimated by might be more accurate than those

Язык: Английский

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Usefulness of the Martin Method for Estimation of Low-Density Lipoprotein Cholesterol in Coronary Atherosclerosis

Medical Principles and Practice, Год журнала: 2017, Номер 27(1), С. 8 - 14

Опубликована: Дек. 4, 2017

This study was conducted to validate the Martin method in coronary atherosclerosis comparison with Friedewald equation.A total of 299 participants a artery calcium score (CACS) ≥300 and serum triglyceride (TG) level <400 mg/dL at Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea, were enrolled this study. Low-density lipoprotein cholesterol (LDL-C) directly measured homogeneous assay (DLDL) estimated by both equation (FLDL) (MLDL). Overall concordances between DLDL LDL-C estimates calculated as percent agreement. The McNemar test used compare rate reclassification FLDL MLDL, determine which differed significantly from each other.Overall concordance MLDL slightly higher than that (73.2 vs. 70.9%, p < 0.001). showed poor performance when TG ≥200 mg/dL, mostly underestimation, represented 64.7% discordance DLDL. however, did not exceed 35.3% all groups.The estimate using strata-specific TG:VLDL ratio 2-fold better direct compared mg/dL. finding suggests could be alternative for estimating is atherosclerosis.

Язык: Английский

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Update on low-density lipoprotein cholesterol quantification

Current Opinion in Lipidology, Год журнала: 2019, Номер 30(4), С. 273 - 283

Опубликована: Май 25, 2019

β-Quantification is considered the reference measurement procedure for low-density lipoprotein cholesterol (LDL-C). However, this technique time-consuming and thus inappropriate routine clinical practice. Therefore, Friedewald equation or homogeneous assays have been widely utilized. As several pitfalls exist with these two methods, a novel method estimating LDL-C was developed by Martin et al. RECENT FINDINGS: Martin's uses strata-specific median triglycerides/very (VLDL-C) ratio on basis of triglycerides non-HDL-C concentrations. Recent studies show that better correlates β-quantification compared equation, especially values at least 150 mg/dl and/or LDL-CD less than 70 mg/dl. Such findings also demonstrated in other ethnic groups (Japanese Korean) disease populations, including diabetes cardiovascular disease, which triglycerides/VLDL-C can be affected.For current therapeutic goal below high-risk patients, accurate assessment levels very low required. could overcome such as underestimation level. Further evaluation participants diverse backgrounds conditions would expand implementation method.

Язык: Английский

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Non-HDL-C/TG ratio indicates significant underestimation of calculated low-density lipoprotein cholesterol (LDL-C) better than TG level: a study on the reliability of mathematical formulas used for LDL-C estimation

Clinical Chemistry and Laboratory Medicine (CCLM), Год журнала: 2020, Номер 59(5), С. 857 - 867

Опубликована: Дек. 24, 2020

Abstract Objectives Low-density lipoprotein cholesterol (LDL-C) is the main laboratory parameter used for management of cardiovascular disease. The aim this study was to compare measured LDL-C with as calculated by Friedewald, Martin/Hopkins, Vujovic, and Sampson formulas regard triglyceride (TG), non-high-density (non-HDL-C)/TG ratio. Methods 1,209 results were compared using ultracentrifugation-precipitation (first study) direct (second methods. Passing-Bablok regression applied percentage difference between (total error) number exceeding total error goal 12% established. Results There good correlation measurement calculation methods (r 0.962–0.985). median ranged from −2.7%/+1.4% (first/second Vujovic formula −6.7%/−4.3% Friedewald formula. numbers underestimated 67 (Vujovic), 134 (Martin/Hopkins), 157 (Samspon), 239 (Friedewald). Less than 7% those obtained samples TG >4.5 mmol/L. From 57% (Martin/Hopkins) 81% (Vujovic) a non-HDL-C/TG ratio <2.4. Conclusions appear be more accurate To minimize significantly results, we propose implementation risk categories according suggest that <1.2, level should not but independently level.

Язык: Английский

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