The Emerging Role of Ferroptosis in Cardiovascular Diseases

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Янв. 26, 2022

Ferroptosis is one type of programmed cell death discovered in recent years, which characterized by iron-dependent lipid peroxidation and participating iron, antioxidant metabolism. different from the traditional types such as apoptosis, necroptosis autophagy morphology, biochemistry genetics. Cardiovascular diseases are considered an important cause non-communicable global population poses a serious threat to human health. Apoptosis has long been thought be major cardiomyocyte death, but now ferroptosis shown play role cardiovascular well. This review will discuss related issues mechanisms its effects on occurrence development diseases, aiming provide novel target for prevention treatment diseases.

Язык: Английский

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Iodine values, peroxide values and acid values of Bohai algae oil compared with other oils during the cooking

Heliyon, Год журнала: 2023, Номер 9(4), С. e15088 - e15088

Опубликована: Апрель 1, 2023

Bohai algae oil contains polyunsaturated fatty acids, such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), which are the very important acids for human body. In Traditional Chinese Cooking, all cooking methods cannot do without oils. However, heat of may always lead to formation large amounts decomposition products that affect sensory, nutritional functional quality oils be unhealthy being cooked, especially food or edible rich in acids. Therefore, objective this study was research effect change heating on characteristics comparison with soybean olive oil.Quality iodine values (IVs), peroxide (POVs) acid (AVs) oil, were measured, conditions factors study.The POVs percentage changes larger than IVs AVs changes. better heated a microwave oven at P-20 within 3min, P-60 P-H1 2min, induction cooker 1500w 1min, electric stove (direct heated) 2min.Bohai suitable used low-temperature short-time salad. This has significance promoting commercial value extensive application daily cooking. It plays theoretical role oil's processing traditional chinese can improve product further expand scope increase richness, diversity universality oil.

Язык: Английский

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Omega-3 Lipid Mediators: Modulation of the M1/M2 Macrophage Phenotype and Its Protective Role in Chronic Liver Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15528 - 15528

Опубликована: Окт. 24, 2023

The complex interplay between dietary factors, inflammation, and macrophage polarization is pivotal in the pathogenesis progression of chronic liver diseases (CLDs). Omega-3 fatty acids (FAs) have brought attention due to their potential modulate inflammation exert protective effects various pathological conditions. eicosapentaenoic acid (EPA) docosahexaenoic (DHA) shown promise mitigating enhancing resolution inflammatory responses. They influence M1/M2 phenotype balance, promoting a shift towards M2 anti-inflammatory phenotype. Specialized pro-resolving mediators (SPMs), such as resolvins (Rvs), protectins (PDs), maresins (MaRs), emerged potent regulators polarization. show properties, by modulating expression cytokines, facilitate phagocytosis apoptotic cells, promote tissue repair. MaR1, particular, has demonstrated significant hepatoprotective polarization, reducing oxidative stress, inhibiting key pathways NF-κB. In context CLDs, nonalcoholic disease (NAFLD) cirrhosis, omega-3s SPMs attenuating injury, regeneration, phenotypes. aim this article was analyze emerging role omega-3 FAs with special interest mechanisms underlying interactions other cell types within microenvironment, focused on CLDs development novel therapeutic strategies.

Язык: Английский

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Effects and Mechanisms of Polyunsaturated Fatty Acids on Age-Related Musculoskeletal Diseases: Sarcopenia, Osteoporosis, and Osteoarthritis—A Narrative Review

Nutrients, Год журнала: 2024, Номер 16(18), С. 3130 - 3130

Опубликована: Сен. 16, 2024

Background: The process of the globally aging population has been accelerating, leading to an increasing social burden. As people age, musculoskeletal system will gradually go through a series degenerative and loss function eventually develop age-related diseases, like sarcopenia, osteoporosis, osteoarthritis. On other hand, several studies have shown that polyunsaturated fatty acids (PUFAs) possess various important physiological functions on health muscles, bones, joints. Objective: This narrative review paper provides summary literature about effects mechanisms PUFAs diseases for prevention management these diseases. Methods: Web Science, PubMed, Science Direct, Scopus databases searched select relevant epidemiological, cellular, animal experiments clinical evidence in recent decades with keywords “polyunsaturated acids”, “PUFAs”, “omega-3”, “omega-6”, “musculoskeletal diseases”, “sarcopenia”, “osteoporosis”, “osteoarthritis”, so on. Results: could prevent treat (sarcopenia, osteoarthritis) by reducing oxidative stress inflammation controlling growth, differentiation, apoptosis, autophagy cells. comprehensive which be helpful exploitation into functional foods drugs their treatment. Conclusions: play role treatment

Язык: Английский

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Diabetic neuropathy: Molecular approach a treatment opportunity

Vascular Pharmacology, Год журнала: 2022, Номер 143, С. 106954 - 106954

Опубликована: Янв. 19, 2022

Язык: Английский

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The Influence of SARS-CoV-2 Infection on Lipid Metabolism—The Potential Use of Lipid-Lowering Agents in COVID-19 Management

Biomedicines, Год журнала: 2022, Номер 10(9), С. 2320 - 2320

Опубликована: Сен. 18, 2022

Several studies have indicated lipid metabolism alterations during COVID-19 infection, specifically a decrease in high-density lipoprotein (HDL) and low-density (LDL) concentrations an increase triglyceride (TG) levels the infection. However, decline triglycerides can also be observed critical cases. A direct correlation between serum cholesterol, HDL-C, LDL-C TGs, severity of disease; these laboratory findings serve as potential markers for patient outcomes. The transmission coronavirus increases proportionally with rising cholesterol cell membrane. This is due to fact that number viral entry spots concentration angiotensin-converting enzyme 2 (ACE2) receptor, crucial penetration. Studies found lower HDL-C correspond higher susceptibility SARS-CoV-2 infection infections general, while were related risk developing them. extremely high infectious diseases associated cardiovascular events. Low are already accepted marker stratification illnesses, prior death older patients. disease still unclear. TG significantly non-surviving severe patients compared those survived; therefore, elevated TG-C may considered indicator uncontrolled inflammation increased death.

Язык: Английский

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Fish and human health: an umbrella review of observational studies

International Journal of Food Sciences and Nutrition, Год журнала: 2022, Номер 73(7), С. 851 - 860

Опубликована: Июнь 26, 2022

Fish represents one of the most important dietary sources omega-3 polyunsaturated fatty acids, which are known to be associated with various health benefits. This study aimed systematically review existing meta-analyses observational studies exploring association between fish intake and outcomes. A systematic search electronic databases was conducted retrieve a total 63 studies. Evidence deemed as possible for higher decreased risk acute coronary syndrome, liver cancer, depression, limited other outcomes (including age-related macular degeneration, Alzheimer's disease, heart failure, all-cause disease mortality, ischaemic stroke) due heterogeneity results potential otherwise inexplicable confounding factors. In conclusion, from epidemiological support mechanistic effects acids high consumption, but evidence needs further corroborated more reliable results.

Язык: Английский

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Association between dietary omega-3 fatty acid intake and all-cause mortality in patients with osteoarthritis: a population-based prospective cohort study

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 3, 2024

A correlation between omega-3 polyunsaturated fatty acids (omega-3 PUFAs) and osteoarthritis (OA) incidence has been established, but research on the long-term outlook of OA patients remains limited. This study investigates association PUFA intake risk all-cause cardiovascular (CV) mortality in U.S. population. cohort 3,467 from National Health Nutrition Examination Survey (NHANES) 2005 to 2018 was studied. Cox proportional hazards regression models, Kaplan-Meier curves, subgroup analyses were used evaluate relationship mortality. The dose-response examined using a restricted cubic spline (RCS) model. Among patients, there 459 deaths 175 CV deaths. Omega-3 PUFAs significantly negatively correlated with (95% CI: 0.59–0.93, p = 0.011) not 0.29–1.04, 0.056). Higher associated 49% decrease curves showed lower rates those higher intake. inverse more pronounced among individuals living partner. analysis indicated linear negative Increased is decreased patients.

Язык: Английский

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Variability in the Clinical Effects of the Omega-3 Polyunsaturated Fatty Acids DHA and EPA in Cardiovascular Disease—Possible Causes and Future Considerations

Nutrients, Год журнала: 2023, Номер 15(22), С. 4830 - 4830

Опубликована: Ноя. 18, 2023

Cardiovascular disease (CVD) that includes myocardial infarction and stroke, is the leading cause of mortality worldwide. Atherosclerosis, primary underlying CVD, can be controlled by pharmacological dietary interventions, including n-3 polyunsaturated fatty acid (PUFA) supplementation. PUFA supplementation, primarily consisting eicosapentaenoic (EPA) docosahexaenoic (DHA), has shown promise in reducing atherosclerosis modulating risk factors, triglyceride levels vascular inflammation. PUFAs act replacing pro-inflammatory types cell membranes plasma lipids, regulating transcription factor activity, inducing epigenetic changes. EPA DHA regulate cellular function through shared differential molecular mechanisms. Large clinical studies on have reported conflicting findings, causing confusion among public health professionals. In this review, we discuss important factors to these inconsistencies, context atherosclerosis, study design effects function. We propose steps improve basic experimental order supplement composition optimization. Finally, understanding poor response PUFAs, development biomarkers for predicting may help towards a more personalized treatment.

Язык: Английский

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Optimal omegas – barriers and novel methods to narrow omega-3 gaps. A narrative review

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Фев. 2, 2024

Dietary intakes of omega-3 long chain polyunsaturated fatty acids (O3LC-PUFAs) such as eicosapentaenoic and docosahexaenoic acid are central to development health across the life course. O3LC-PUFAs have been linked neurological development, maternal child etiology certain non-communicable diseases including age-related cognitive decline, cardiovascular disease, diabetes. However, dietary inadequacies exist in United Kingdom on a wider global scale. One predominant source is fish oils. growing concerns about overfishing, oceanic contaminants dioxins microplastics trend towards plant-based diets appear be acting cumulative barriers from these food sources. Microalgae an alternative provider O3LC-PUFA-rich The delivery into systems gaining interest. present narrative review aims discuss obtaining suitable levels for wellbeing. It then discusses potential ways forward focusing innovative methods utilize oils use fortification strategies, bioengineered plants, microencapsulation, microalgae.

Язык: Английский

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