Journal of Hypertension,
Год журнала:
2024,
Номер
42(7), С. 1212 - 1225
Опубликована: Март 8, 2024
Background:
Resistant
hypertension
is
a
severe
phenotype
in
that
may
be
driven
by
interactions
between
genetic
and
environmental
factors.
Specific
changes
gut
microbiota
metabolites
have
been
shown
to
influence
cardiovascular
disease
progression.
However,
microbial
metabolomic
associated
with
resistant
remain
elusive.
Methods:
In
this
study,
the
microbiome
of
30
participants
hypertension,
controlled
nonhypertension
was
characterized
using
16S
rRNA
amplicon
sequencing.
addition,
serum
metabolome
same
population
assessed
untargeted
metabolomics.
Results:
The
alpha
diversity
decreased,
were
also
observed
composition
microbiota.
group
elevated
levels
Actinobacteitia
Proteobacteria.
Twenty-three
genera
found
significantly
different
abundances
as
well
55
nonhypertension.
Compared
group,
Rothia
Sharpea
more
abundant.
Escherichia–Shigella
,
Lactobacillus
Enterococcus
Untargeted
metabolomics
provided
distinctly
metabolic
profiles
for
three
groups
identified
range
differential
metabolites.
These
mainly
pathway
glycerophospholipid
metabolism.
Furthermore,
correlation
analysis
evidence
new
hypertension.
Conclusion:
conclusion,
our
study
provides
comprehensive
understanding
metabolites,
suggesting
treatment
resistance
patients
related
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Сен. 3, 2024
Pyropia
spp.
seaweeds
are
delicious
and
nutritious
red
algae
widely
consumed
for
a
long
history.
However,
due
to
the
non-digestibility
of
cell
wall
components
by
human
intestinal
tract,
bioaccessibility
intracellular
bioactive
compounds
is
low.
The
current
industrial
processing
food
drying
roasting
cannot
break
down
wall;
however,
studies
indicate
that
fermentation
food-derived
microorganisms
an
efficient
method
solve
this
problem.
This
paper
reviews
research
on
spp.,
including
manufacturing
process,
alterations
in
chemical
composition,
flavor
properties,
bioactivities,
mechanisms.
Furthermore,
limitations
opportunities
developing
explored.
Studies
demonstrated
key
metabolites
fermented
were
degraded
polysaccharides,
released
phenolic
flavonoids,
formed
amino
acids,
which
possessed
bioactivities
such
as
antioxidant,
anti-glycation,
anti-diabetic,
lipid
metabolism
regulation
beneficial
health.
increased
implied
promoted
components.
Notably,
positively
contributed
safety
food.
In
conclusion,
benefits
nutrition,
flavor,
bioactivity,
suggest
technology
has
promising
future
application
industry.
EBioMedicine,
Год журнала:
2022,
Номер
86, С. 104349 - 104349
Опубликована: Ноя. 11, 2022
The
application
of
cold
exposure
has
emerged
as
an
approach
to
enhance
whole-body
lipid
catabolism.
global
effect
on
the
lipidome
in
humans
been
reported
with
mixed
results
depending
intensity
and
duration
cold.This
secondary
study
was
based
data
from
a
previous
randomized
cross-over
trial
(ClinicalTrials.gov
ID:
NCT03012113).
We
performed
sequential
lipidomic
profiling
serum
during
120
min
human
volunteers.
Next,
intracellular
lipolysis
blocked
mice
(eighteen
10-week-old
male
wild-type
C57BL/6J)
using
small-molecule
inhibitor
adipose
triglyceride
lipase
(ATGL;
Atglistatin),
were
exposed
for
similar
duration.
quantitative
assessed
in-depth
Lipidyzer
platform.In
humans,
gradually
increased
circulating
free
fatty
acids
reaching
maximum
at
60
min,
transiently
decreased
total
triacylglycerols
(TAGs)
only
30
min.
A
broad
range
TAG
species
initially
decreased,
particular
unsaturated
polyunsaturated
≤5
double
bonds,
while
after
significant
increase
observed
≥6
bonds
humans.
mechanistic
revealed
that
cold-induced
TAGs
largely
prevented
by
blocking
lipase.We
interpret
these
findings
feeds
thermogenic
tissues
TAG-derived
combustion,
resulting
decrease
species,
followed
hepatic
production
induced
liberation
stemming
tissue.This
work
supported
Netherlands
CardioVascular
Research
Initiative:
'the
Dutch
Heart
Foundation,
Federation
University
Medical
Centers,
Organisation
Health
Development
Royal
Academy
Sciences'
[CVON2017-20
GENIUS-II]
Patrick
C.N.
Rensen.
Borja
Martinez-Tellez
is
individual
postdoctoral
grant
Fundación
Alfonso
Martin
Escudero
Maria
Zambrano
fellowship
Ministerio
de
Universidades
y
la
Unión
Europea
-
NextGenerationEU
(RR_C_2021_04).
Lucas
Jurado-Fasoli
pre-doctoral
Spanish
Ministry
Education
(FPU19/01609)
Albert
Renold
Travel
Fellowship
European
Foundation
Study
Diabetes
(EFSD).
Giera
partially
NWO
XOmics
project
#184.034.019.
LWT,
Год журнала:
2023,
Номер
182, С. 114875 - 114875
Опубликована: Май 15, 2023
n-3
Long-chain
polyunsaturated
fatty
acids
(LC-PUFAs)
in
glyceride
form
have
attracted
much
attention
due
to
their
nutritional
value
and
high
bioavailability.
In
this
work,
Thermomyces
lanuginosus
lipase
(TL
100
L)
was
used
selectively
hydrolyze
tuna
oil
for
preparing
glycerides
enriched
with
LC-PUFAs.
Effects
of
reaction
variables
on
the
hydrolysis
were
optimized
by
response
surface
methodology,
optimal
conditions
as
follows:
temperature
54
°C,
enzyme
load
3%,
time
6
h,
mass
ratio
water
1.5:1.
Under
these
conditions,
resulting
degree
55.01%,
total
content
eicosapentaenoic
acid
docosahexaenoic
fraction
found
be
46.39%.
The
final
product
mainly
composed
diacylglycerols
(53.93%)
triacylglycerols
(34.58%)
after
removal
free
acids.
This
paper
provides
a
simple
suitable
method
industrial
production
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3769 - 3769
Опубликована: Март 28, 2024
An
organism's
ability
to
function
properly
depends
not
solely
on
its
diet
but
also
the
intake
of
nutrients
and
non-nutritive
bioactive
compounds
that
exert
immunomodulatory
effects.
This
principle
applies
both
healthy
individuals
and,
in
particular,
those
with
concomitant
chronic
conditions,
such
as
type
2
diabetes.
However,
current
food
industry
widespread
use
highly
processed
foods
often
lead
nutritional
deficiencies.
Numerous
studies
have
confirmed
occurrence
immune
system
dysfunction
patients
article
elucidates
impact
specific
function,
which
maintains
homeostasis
organism,
a
particular
emphasis
The
role
macronutrients,
micronutrients,
vitamins,
selected
substances,
omega-3
fatty
acids,
coenzyme
Q10,
alpha-lipoic
acid,
was
taken
into
consideration,
outlined
minimum
range
tests
ought
be
performed
order
either
directly
or
indirectly
determine
severity
malnutrition
this
group
patients.
Journal of Hypertension,
Год журнала:
2024,
Номер
42(7), С. 1212 - 1225
Опубликована: Март 8, 2024
Background:
Resistant
hypertension
is
a
severe
phenotype
in
that
may
be
driven
by
interactions
between
genetic
and
environmental
factors.
Specific
changes
gut
microbiota
metabolites
have
been
shown
to
influence
cardiovascular
disease
progression.
However,
microbial
metabolomic
associated
with
resistant
remain
elusive.
Methods:
In
this
study,
the
microbiome
of
30
participants
hypertension,
controlled
nonhypertension
was
characterized
using
16S
rRNA
amplicon
sequencing.
addition,
serum
metabolome
same
population
assessed
untargeted
metabolomics.
Results:
The
alpha
diversity
decreased,
were
also
observed
composition
microbiota.
group
elevated
levels
Actinobacteitia
Proteobacteria.
Twenty-three
genera
found
significantly
different
abundances
as
well
55
nonhypertension.
Compared
group,
Rothia
Sharpea
more
abundant.
Escherichia–Shigella
,
Lactobacillus
Enterococcus
Untargeted
metabolomics
provided
distinctly
metabolic
profiles
for
three
groups
identified
range
differential
metabolites.
These
mainly
pathway
glycerophospholipid
metabolism.
Furthermore,
correlation
analysis
evidence
new
hypertension.
Conclusion:
conclusion,
our
study
provides
comprehensive
understanding
metabolites,
suggesting
treatment
resistance
patients
related
