Reviews in Cardiovascular Medicine,
Год журнала:
2024,
Номер
25(12)
Опубликована: Дек. 25, 2024
With
advances
in
therapies
to
reduce
cardiovascular
events
and
improvements
coronary
imaging,
an
increasing
number
of
clinical
trials
have
demonstrated
that
treatments
artery
disease
are
associated
with
favorable
effects
on
atherosclerotic
plaque
size
characteristics.
It
has
been
observed
various
drugs
may
induce
regression
enhance
stability
after
formation.
Numerous
conducted
verify
the
occurrence
stabilization
their
beneficial
events.
Using
invasive
imaging
techniques
such
as
intravascular
ultrasound
(IVUS)
optical
coherence
tomography
(OCT),
researchers
able
gather
evidence
supporting
existence
regression.
In
this
review,
we
explore
possible
mechanisms
regression,
summarize
features
assemble
from
studies
used
different
observational
endpoints.
Diabetology & Metabolic Syndrome,
Год журнала:
2025,
Номер
17(1)
Опубликована: Апрель 28, 2025
Among
noncommunicable
diseases,
cardiovascular
disease
(CVD)
is
the
leading
cause
of
mortality
and
morbidity.
In
China,
diabetes
renowned
for
its
high
incidence
rate,
body
roundness
index
(BRI)
an
emerging
indicator
assessing
obesity,
particularly
abdominal
obesity.
High
BRI
may
lead
to
new-onset
CVD
events.
However,
relationships
between
in
individuals
with
or
without
remain
unclear.
Data
this
analysis
were
extracted
from
China
Health
Retirement
Longitudinal
Study
(CHARLS).
Our
research
utilized
a
cohort
that
was
meticulously
assessed
over
period
2011
2018,
encompassing
comprehensive
follow-up
17,708
participants.
Ultimately,
study
focused
on
subset
6,737
aged
45
years
older.
Methodological
approaches
include
Cox
regression,
Kaplan-Meier
survival
analysis,
restricted
cubic
splines
(RCS)
receiver
operating
characteristic
(ROC)
curve
subgroup
mediation
explore
interest.
This
included
participants,
all
whom
above
age
45.
findings
revealed
within
demographic
group,
1,481
(22.0%)
patients
experienced
CVD.
The
further
group
characterized
by
non-diabetes
mellitus
(Non-DM)
had
lowest
cumulative
compared
(DM)
group.
Multivariate
regression
fully
adjusted
model
(Model
3)
(HR
=
1.122,
95%
CI
1.080
1.167),
associated
risk
Non-DM
during
three-wave
follow-up.
RCS
positive,
linear-like
dose‒dependent
relationship
(P
0.007,
P
nonlinearity
0.938).
Smoking
could
affect
ability
predict
rate
total
population
interaction
0.007).
Moreover,
mediating
effect
among
diabetic
pronounced
long
term,
exceeding
4
years.
demonstrate
significant
association
non-diabetic
individuals,
influencing
middle-aged
elderly
Chinese
populations
through
playing
role.
As
obesity
indicator,
provides
valuable
tool
early
detection
intervention
Not
applicable.
Perioperative Medicine,
Год журнала:
2025,
Номер
14(1)
Опубликована: Май 9, 2025
Arrhythmias
are
a
frequent
complication
in
the
postoperative
period
following
surgical
procedures.
This
study
aims
to
investigate
incidence
and
contributing
factors
of
arrhythmias
elderly
patients
with
lung
cancer
who
have
undergone
thoracoscopic
surgery,
thereby
providing
scientific
evidence
support
clinical
treatment
nursing
care.
retrospective
cohort
included
diagnosed
underwent
at
our
hospital
between
June
1,
2022,
October
31,
2024.
Patients
were
categorized
into
two
groups
based
on
development
surgery:
arrhythmia
group
non-arrhythmia
group.
A
comparative
analysis
data
was
conducted
these
groups.
total
208
enrolled,
an
19.71%
(41/208).
Logistic
regression
identified
age
≥
70
years
(OR
=
2.586,
95%
CI:
1.805-3.221),
hypertension
2.761,
2.103-3.588),
history
smoking
2.070,
1.741-2.446),
TNM
stage
II
3.181,
2.842-3.690),
pulmonary
infection
2.122,
1.836-2.690),
constipation
2.495,
1.988-3.072)
as
independent
risk
for
(all
p
<
0.05).
The
surgery
is
relatively
high.
Targeted
interventions
addressing
essential
mitigate
arrhythmias.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(10), С. 4731 - 4731
Опубликована: Май 15, 2025
Atherosclerosis
is
a
major
contributor
to
ischemic
stroke.
Carotid
plaque
instability
critical
determinant
of
cerebrovascular
events,
yet
its
identification
remains
challenging.
One
chemokine
with
well-documented
proatherogenic
properties
MCP-1,
whose
levels
are
elevated
in
patients
conditions
such
as
hypertension,
obesity,
and
atherosclerosis.
This
study
evaluated
the
association
between
serum
MCP-1
levels,
carotid
determined
by
ultrasound
gray-scale
median
(GSM)
analysis
77
who
underwent
endarterectomy.
Patients
were
classified
body
mass
index.
Serum
concentrations
measured
using
enzyme-linked
immunosorbent
assay
technique.
Analyses
performed
explore
relationships
clinical
parameters,
biochemical
markers,
stability.
Increasing
weight
was
paralleled
higher
lower
GSM
values,
indicative
unstable
plaques.
Moreover,
logistic
regression
identified
one
independent
predictors
instability,
particularly
overweight
hypertensive
patients.
These
results
indicate
potential
usefulness
biomarker
confirming
negative
effect
obesity
promoting
other
known
cardiovascular
risk
factors
causing
Diabetology & Metabolic Syndrome,
Год журнала:
2025,
Номер
17(1)
Опубликована: Май 20, 2025
This
study
aimed
to
construct
a
scientific,
accurate,
and
readily
applicable
clinical
all-cause
mortality
prediction
model
for
patients
with
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
enhance
the
efficiency
of
management
improve
patient
prognosis.
was
retrospective
cohort
based
on
National
Health
Nutrition
Examination
Survey
database.
The
17,861
participants
diagnosed
MASLD
were
randomly
assigned
either
training
(n
=
12,503)
or
validation
5358).
Potential
predictors
subjected
LASSO
regression
analysis,
independent
risk
factors
subsequently
identified
through
multivariate
Cox
analysis.
An
constructed
significant
predictors,
nomogram
generated
illustrate
survival
probability
at
various
time
points.
model's
performance
evaluated
using
receiver
operating
characteristic
(ROC),
calibration,
decision
curve
analysis
(DCA)
curves.
A
multiple
several
significantly
influencing
in
MASLD.
These
included
gender,
age,
smoking
status,
hypertension,
red
blood
cell
count,
albumin,
glutamyl
transpeptidase,
glycosylated
hemoglobin,
creatinine.
predictive
demonstrated
high
accuracy
cohorts,
AUC
values
approaching
0.85
3,
5,
10
years,
respectively.
Calibration
DCA
curves
employed
verify
stability
generalizability
model.
We
successfully
validated
an
patients.
provides
powerful
tool
assessment
treatment
decision-making.
Die Anaesthesiologie,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
Zusammenfassung
Hintergrund
Die
akzidentelle
Duraperforation
(ADP)
ist
eine
seltene,
aber
ernst
zu
nehmende
Komplikation
der
rückenmarknahen
Anästhesie,
die
einem
Postpunktionskopfschmerz
(PDPH),
welcher
das
Wohlbefinden
betroffenen
Frauen
erheblich
beeinträchtigt,
führen
kann.
Ziel
Arbeit
vorliegende
untersucht
Patientinnencharakteristika,
Behandlung
und
Behandlungsergebnis
des
PDPH
nach
ADP
in
Geburtsmedizin
vergleicht
konservative
Therapie
mit
epiduralen
Blut-Patch
(EBP).
Es
werden
charakteristische
Merkmale,
Symptomverläufe,
Nebenwirkungen
Komplikationen
beider
Therapieansätze
dargestellt.
Methoden
wurden
Daten
von
73
Patientinnen
aus
9
deutschen
Studienzentren
europäischen
Studie
European
Practices
the
Management
of
Accidental
Dural
Puncture
Obstetrics
(EPIMAP),
einer
prospektiven
multizentrischen
Kohortenstudie,
deskriptiv
analysiert.
Ergebnisse
Im
Zeitraum
2016
bis
2018
erhielten
56
(76,7
%)
eingeschlossenen
einen
EBP,
17
konservativ
behandelt
(23,3
%).
Kollektiv
konservativen
wurde
auf
numerischen
Schmerzskala
(NRS)
Interquartilenbereich
(IQR)
im
Liegen
ein
medianes
Schmerzniveau
2
(IQR
1;
3)
Stehen
7
(5;
8)
angegeben.
andere
Gruppe
gab
vor
Anlage
EBP
Schmerzintensität
NRS
3
(1;
7)
8,5
(7;
10)
an.
Das
24
h
lag
bei
0
(0;
2)
1
Stehen.
behandelten
beschrieben
Entlassung
Schmerzrückgang
1)
4).
15
erneutem
stationär
aufgenommen
(26,8
%),
zweiten
(60
Diskussion
Der
stellt
effektive
Behandlungsoption
zur
Senkung
eines
Postpunktionskopfschmerzes
dar,
wobei
Wahl
zwischen
konservativer
v.
a.
Intensität
Kopfschmerzes
beeinflusst
sein
scheint.
dieser
Untersuchung
unterstreichen
Bedeutung
individualisierten
Behandlungsansatzes.
Journal of Surgical Research,
Год журнала:
2025,
Номер
311, С. 78 - 85
Опубликована: Май 22, 2025
Thromboangiitis
obliterans
(TAO)
is
potentially
associated
with
smoking,
although
its
precise
pathogenesis
remains
unclear.
Trimethylamine
N-oxide
(TMAO)
has
been
implicated
in
the
induction
of
various
cardiovascular
and
cerebrovascular
diseases.
However,
role
TMAO
TAO
not
reported.
This
study
aimed
to
investigate
relationship
between
TMAO,
TAO.
Thirty-three
patients
diagnosed
hospitalized
for
treatment
January
2018
July
2024
were
included
study.
Healthy
smokers
(n
=
38)
nonsmokers
35)
randomly
recruited
matched
age,
sex,
education
level
as
controls.
Subsequently,
we
analyzed
their
clinical
characteristics,
levels
immune
inflammatory
markers.
Patients
exhibited
significantly
higher
Toll-like
receptor
4
(TLR4),
advanced
glycation
end
products,
interleukin
(IL)-1β,
IL-18,
tumor
necrosis
factor-alpha,
high
mobility
group
box
1,
nuclear
factor-κB
(NF-κB),
phosphorylated
NF-κB
(pNF-κB)
than
those
smoking
nonsmoking
control
groups
(all
P
<
0.05).
The
also
TLR4,
IL-1β,
NF-κB,
pNF-κB
0.05)
group.
factor-alpha
underage
adult
was
correlated
Rutherford
classification
TAO,
patients'
status
(including
total
years
average
daily
cigarette
consumption),
markers
These
findings
indicate
that
gut
microbiota
plays
a
significant
likely
involved
progression
acting
contributing
factor.
underlying
mechanism
may
involve
activation
immune-inflammatory
pathways,
specifically
1-receptor
products/TLR4-NF-κB
pathway.
