Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2‐SLC7A11 Signaling Pathway

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Gaudichaudione H (GH) is a naturally occurring small molecular compound derived from Garcinia oligantha Merr . (Clusiaceae), but the full pharmacological functions remain unclear. Herein, potential of GH in disulfidptosis regulation, novel form programmed cell death induced by disulfide stress explored. The omics results indicated that NRF2 signaling could be significantly activated GH. targets are associated with hepatocarcinogenesis and death. Moreover, both glutathione (GSH) metabolism NADP + ‐NADPH affected GH, indicating regulation. It also observed enhanced sensitivity hepatocellular carcinoma (HCC) cells to disulfidptosis, which dependent on activation NRF2‐SLC7A11 pathway. increased levels promoted transcription target gene, SLC7A11, through autophagy‐mediated non‐canonical mechanism. Under condition glucose starvation, GH‐induced upregulation SLC7A11 aggravated uptake cysteine, disturbance GSH synthesis, depletion NADPH, accumulation molecules, ultimately leading formation bonds between different cytoskeleton proteins eventually. Collectively, findings underscore role promoting cancer thereby offering promising avenue for treatment drug‐resistant HCC clinical settings.

Язык: Английский

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Risk stratification and early detection biomarkers for precision HCC screening

Hepatology, Год журнала: 2022, Номер unknown, С. n/a - n/a

Опубликована: Сен. 9, 2022

Abstract Hepatocellular carcinoma (HCC) mortality remains high primarily due to late diagnosis as a consequence of failed early detection. Professional societies recommend semi‐annual HCC screening in at‐risk patients with chronic liver disease increase the likelihood curative treatment receipt and improve survival. However, recent dynamic shift etiologies from viral metabolic diseases has significantly increased potential target population for screening, whereas annual incidence rate become substantially lower. Thus, contemporary etiologies, traditional approach might not be practical cost‐effective. consists (i) definition rational population, subsequent (ii) repeated application detection tests at regular intervals. The suboptimal performance currently available highlights an urgent need new modalities strategies In this review, we overview developments clinical, molecular, imaging‐based tools address current challenge, discuss conceptual framework approaches their clinical translation implementation. These encouraging progresses are expected transform “one‐size‐fits‐all” into individualized precision ultimately poor prognosis foreseeable future.

Язык: Английский

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Immunotherapy as a Neoadjuvant Therapy for a Patient with Hepatocellular Carcinoma in the Pretransplant Setting: A Case Report

Current Oncology, Год журнала: 2022, Номер 29(6), С. 4267 - 4273

Опубликована: Июнь 15, 2022

Systemic combination therapy of immune checkpoint inhibitors and vascular endothelial growth factors have provided the basis for improved outcomes in select patients with unresectable or metastatic hepatocellular carcinoma. However, resectable disease, surgery alone an orthotopic liver transplant remains standard care. Within realms oncology, neoadjuvant systemic is currently being evaluated as a potential strategy to improve HCC. Here, we report excellent response significant downstaging safe manner after treatment atezolizumab bevacizumab patient diagnosed poorly differentiated As result observed outcomes, was listed (OLT) evaluation transplanted successfully.

Язык: Английский

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Advances in radiotherapy and immunity in hepatocellular carcinoma

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 4, 2023

Primary liver cancer is one of the most common malignant tumours worldwide; it caused approximately 830,000 deaths in 2020. Hepatocellular carcinoma (HCC) type primary cancer, accounting for over 80% all cases. Various methods, including surgery, chemotherapy, radiotherapy, and radiofrequency ablation, have been widely used treatment HCC. With advancement technology, radiotherapy has become increasingly important comprehensive However, due to insufficient sensitivity tumour cells radiation, there are still multiple limitation clinical application radiotherapy. In recent years, role immunotherapy revealed, more researchers turned their attention combined hope achieving better outcomes. This article reviews progress on radiation therapy HCC current status its with immunotherapy, discusses prospects value radioimmunotherapy

Язык: Английский

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ESR Essentials: diagnosis of hepatocellular carcinoma—practice recommendations by ESGAR

European Radiology, Год журнала: 2024, Номер 34(4), С. 2127 - 2139

Опубликована: Фев. 21, 2024

Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and a leading cause of cancer related death worldwide. Current guidelines for noninvasive diagnosis HCC are provided by European Association Study Liver (EASL), American Diseases (AASLD) which endorsed Imaging Reporting Data System (LI-RADS) algorithm, Korean Cancer Association-National Center (KLCA-NCC), Asian-Pacific (APASL). These allow in high-risk patients presence typical imaging features on contrast-enhanced CT, MRI, or ultrasound. Size, non-rim arterial phase hyperenhancement, non-peripheral washout, enhancing capsule, growth major they should be combined HCC. This article provides concise relevant practice recommendations aimed at general radiologist audience, summarizing best informing essential criteria HCC, while also discussing population criteria, modalities, according to current guidelines. KEY POINTS: • Noninvasive hepatocellular can only high risk. Contrast-enhanced CT MRI first-line exams Major provide definitive

Язык: Английский

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LI-RADS Ultrasound Surveillance Version 2024: Comparison With Version 2017 for Hepatocellular Carcinoma Detection and Risk Factors for Visualization Score C

American Journal of Roentgenology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Background: The LI-RADS Ultrasound Surveillance algorithm was updated in 2024, incorporating alpha-fetoprotein (AFP) and visualization score of VIS-C into management recommendations after nonpositive results. Objective: This study aimed to compare the diagnostic performance version 2017 (v2017) 2024 (v2024) for hepatocellular carcinoma (HCC) detection at-risk patients identify predictors on follow-up surveillance examinations. Methods: retrospective analysis included 407 (median age, 56 years; 230 male, 177 female) with cirrhosis who underwent rounds semi-annual ultrasound as part a prospective trial from November 2011 December 2012. Two radiologists independently assigned categories round-1 examinations scores round-2 examinations; third radiologist adjudicated disagreements. AFP considered positive if elevated or increasing pre-enrollment values, per v2024 criteria. Reference standard HCC biopsy LR-5 observation MRI. Diagnostic compared between v2017 v2024. Logistic regression analyses were performed VIS-C, attention risk factors described Results: diagnosed 28 (6.9%) patients. For reader 1, v2024, v2017, showed greater sensitivity 1 (64.3% vs 42.9%, p=.03) 2 39.3%, p=.02), lower specificity (82.0% 92.6%, p<.001) (82.3% 92.9%, p<.001). All seven detected by but not using consensus assessments had an AFP; two also AFP. In 299 negative results, only independent predictor (adjusted OR=21.0, [95% CI, 10.8-40.8], 88 these no factor significant univariable association repeat VIS-C. Conclusion: Compared higher detection, related primarily increasing, rather than elevated, subsequent initial result. Clinical Impact: findings support use improve

Язык: Английский

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GINS4 silencing mediates hepatocellular cancer cell proliferation, cycle and ferroptosis through POLE2

Cellular Signalling, Год журнала: 2025, Номер 131, С. 111742 - 111742

Опубликована: Март 11, 2025

Язык: Английский

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Impact of oseltamivir on the risk of cancer

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Фев. 26, 2024

Mounting evidence has revealed the anti-cancer activity of various anti-viral drugs. Oseltamivir phosphate (OP), namely Tamiflu®, is routinely used to combat influenza infections. Although indicated effects OP in vitro and vivo, little information known about effect use on cancers humans. A nationwide population-based cohort study involving 13,977,101 cases with 284,733 receiving was performed examine association between using National Health Insurance Research Database Taiwan 2009 2018. The found that users showed a significantly lower incidence lung cancer, colon liver, intrahepatic bile duct oral pancreas esophagus stomach prostate cancer. Additionally, exhibited risk cancer-related mortality (adjusted HR=0.779; 95% confidence interval [CI] 0.743-0.817; p<0.001) reduced developing liver cancer HR=0.895; CI 0.824-0.972; p=0.008), HR=0.646; 0.522-0.799; HR=0.587; 0.346-0.995; p=0.048). Notably, had significant reduction occurrence over 10-year period follow-up stage at diagnosis. These findings first suggest beneficial therapeutic potential for certain cancers, especially

Язык: Английский

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Application of Machine Learning Techniques to Assess Alpha-Fetoprotein at Diagnosis of Hepatocellular Carcinoma

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 1996 - 1996

Опубликована: Фев. 7, 2024

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and associated with high mortality rates. Approximately 80% of cases occur in cirrhotic livers, posing a significant challenge for appropriate therapeutic management. Adequate screening programs high-risk groups are essential early-stage detection. The extent extrahepatic spread hepatic functional reserve recognized as two influential prognostic factors. In this retrospective multicenter study, we utilized machine learning (ML) methods to analyze predictors at time diagnosis total 208 patients. eXtreme gradient boosting (XGB) method achieved highest values identifying key factors HCC diagnosis. etiology was found be variable strongly poorer prognosis. widely used Barcelona Clinic Liver Cancer (BCLC) classification our setting demonstrated superiority over TNM classification. Although alpha-fetoprotein (AFP) remains commonly biological marker, elevated levels did not correlate reduced survival. Our findings suggest need explore new biomarkers individualized management these

Язык: Английский

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Hepatocellular Carcinoma Immunotherapy: Predictors of Response, Issues, and Challenges

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11091 - 11091

Опубликована: Окт. 15, 2024

Immune checkpoint inhibitors (ICIs), such as durvalumab, tremelimumab, and atezolizumab, have emerged a significant therapeutic option for the treatment of hepatocellular carcinoma (HCC). In fact, efficacy ICIs single agents or part combination therapies has been demonstrated in practice-changing phase III clinical trials. However, confront several difficulties, including lack predictive biomarkers, primary secondary drug resistance, treatment-related side effects. Herein, we provide an overview current issues future challenges this setting.

Язык: Английский

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