Changes of Mycoplasma Pneumoniae Pneumonia Among Chinese Children, 2019-2023 DOI Creative Commons

Ping Hong,

Yueming Wu, Lu Gan

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Abstract Objective To describe the epidemiology and clinical characteristics of Mycoplasma Pneumoniae-associated hospitalizations among children in Shanghai, a south province China before, during post-COVID-19 Pandemic (2019-2023). Methods From January 2019 to December 2023, an observational cross-sectional study was conducted, trend, season distribution age group hospitalization with mycoplasma pneumoniae pneumonia investigated. The data 2023 were compared changes two periods prevalence. Results 1123 hospitalized by rolled. number peaked 2019（411cases） 2023（548 cases）, COVID-19 pandemic (2020-2022), cases decreased significantly, especially 2020 (37 cases). Children aged 3-7 years account for majority pneumonia，208 (50.6%) 2019,22 (59.5%) 2020,56 (65.1%),18 (43.9%) 2022. However, 267 (48.7%) > 7 old 2023. mean time duration fever before admission total longer than those 2019(4.91±2.48 days vs 3.91±2.60 , P=0.000; 5.56±3.34 4.51±3.31 days, P=0.000，respectively).Cases severe labor post pandemic, higher 2019( 195(35.6%) vs60(14.6%),P=0.000; 288(52.6%)vs 113(27.5%),P=0.000，separately). Conclusion During epidemic, exceedingly. seasonal prevalence not changed pandemic. proportion lobar increased

Язык: Английский

Mycoplasma pneumoniae at the rise not only in China: rapid increase of Mycoplasma pneumoniae cases also in Spain DOI Creative Commons

Ana Dacosta Urbieta,

Gema Barbeito Castiñeiras,

Irene Rivero‐Calle

и другие.

Emerging Microbes & Infections, Год журнала: 2024, Номер 13(1)

Опубликована: Март 18, 2024

After the use of facemasks, other isolation measures enacted during SARS-CoV-2 pandemic were lifted, respiratory pathogens, such as RSV, reappeared, but until November 2023 WHO alert for China,

Язык: Английский

Процитировано

23
Resurgence of common respiratory viruses and mycoplasma pneumoniae after ending the zero-COVID policy in Shanghai DOI Creative Commons
Pengcheng Liu, Menghua Xu, Lijuan Lu

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 13, 2025

China has adhered to policies of zero-COVID for almost three years since the outbreak COVID-19, which remarkably affected circulation respiratory pathogens. However, begun end in late 2022. Here, we reported a resurgence common viruses and Mycoplasma pneumoniae with unique epidemiological characteristics among children after ending policy Shanghai, China, 2023. Children hospitalized acute tract infections were enrolled from January 2022 December Nine 2 atypical bacteria detected specimens patients using multiplex PCR-based assay. The data analyzed compared between periods before (2022) (2023) policies. A total 8550 enrolled, including 6170 2023 2380 Rhinovirus (14.2%) was dominant pathogen 2022, however, (38.8%) Compared detection rates pathogens significantly increased (72.9% vs. 41.8%, p < 0.001). An out‐of-season epidemic syncytial virus observed during spring summer median age infected greater than that Besides, mixed more frequent (23.8% 28.9%, is now facing multiple epidemics changing seasonality, altered distribution, increasing infection Our finding highlights need public health interventions prepare outbreaks post-COVID-19 era.

Язык: Английский

Процитировано

4
Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in China DOI Creative Commons

Yuzhu Miao,

Jungen Li,

Linlin Huang

и другие.

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Год журнала: 2025, Номер 51(1)

Опубликована: Янв. 23, 2025

This study aimed to describe the epidemiological trends of Mycoplasma pneumoniae (MP) infection among children with acute respiratory tract infections (ARTIs) before, during and after COVID-19 pandemic, evaluating impact non-pharmaceutical interventions (NPIs) on epidemiology MP infection. Children ARTIs admitted Children's Hospital Soochow University (SCH) from January 2010 December 2023 underwent nucleic acid PCR assay were included. Clinical data age, sex, onset time detection result collected analyzed. All 122,984 inpatients enrolled, in which 20.8% (25659/122984) tested positive, including 19.4% (14139/72662) for male 22.9% (11520/50322) female. It was a statistically significant difference between two genders (p < 0.05). In addition, positive rate highest age group > 6 years old each year During 14-year period, has experienced four peaks 2012, 2013, 2019, 2023. Before NPIs prevalence showed seasonality, number positivity reached their peak August. However, remained at low level NPIs. After abolition NPIs, obviously increased high level. The could reduce spread change its epidemic season, but it not changed susceptible population

Язык: Английский

Процитировано

1
Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease Inhibitors DOI
Bo Qin,

Chengwei Wu,

Binbin Zhao

и другие.

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(12), С. 10211 - 10232

Опубликована: Июнь 13, 2024

Papain-like protease (PLpro) is a promising therapeutic target for its pivotal role in the life cycle of SARS-CoV-2. A series 1,2,4-oxadiazole derivatives was designed and synthesized via ring formation strategy based on SARS-CoV-2 PLpro-GRL0617 complex structure. Systematic structure-activity relationship studies revealed that introducing oxadiazole aryl carboxylic acid moieties to GRL0617 enhanced enzymatic inhibition activity, affinity, deubiquitination capacity toward PLpro. 1,2,4-Oxadiazole compounds

Язык: Английский

Процитировано

3
Respiratory pathogen analysis in pediatric inpatients unraveled the infection pattern of Mycoplasma pneumoniae post the COVID-19 pandemic DOI Creative Commons
Qihong Chen,

Ruizhi Xu,

Ying Gu

и другие.

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Окт. 9, 2024

Background To counteract the COVID-19 pandemic, nonpharmaceutical interventions (NPIs) were implemented globally, exerting a profound influence on wide spectrum of infectious diseases, encompassing respiratory tract infections (RTIs). Subsequent to easing NPIs, China experienced significant outbreak Mycoplasma pneumoniae (MP). Methods Over decade from 2015 2024, our study scrutinized 12 common diseases among pediatric children. Etiologically diagnostic data and clinical outcome metrics children with RTIs, tested for 13 pathogens, analyzed evaluate changes during after pandemic compared pre-pandemic periods, notable emphasis age profile coinfection patterns MP. Results Among 57,471 hospitalized children, 23,178 diagnosed diseases. Under most declined levels, rebounding by 69.64% in 2023. While infection rate pathogens decreased, cases syncytial virus increased period extensive NPI implementation. In 2023, intensive care unit durations these increased, suggesting greater severity illness 2019. MP exhibited highest (31.38% average), post-pandemic due increase &lt;3 year olds rise older NPIs reduced coinfections mitigated their severity, while bacterial over span 5 years, contrast impact viral pathogens. Conclusion effectively curb transmission resulting average altered post-pandemic.

Язык: Английский

Процитировано

3
Epidemiology of respiratory infections during the different levels of non-pharmaceutical interventions DOI Creative Commons
Ting Shi,

Linlin Huang,

Jianmei Tian

и другие.

BMC Pediatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Май 11, 2025

This study aimed to describe epidemiological changes of common respiratory pathogens in children with acute infections (ARIs) during the different levels non-pharmaceutical interventions(NPIs). In this retrospective study, we analyzed prevalence 12 from September 2021 through February 2024 all inpatients ARIs admitted Children's Hospital Soochow University(SCH). We compared detection rates these at public NPI measures. total, 27,851 samples were analyzed, including 15,231 boys and 12,620 girls. Under strict NPIs, more commonly boy infants (p < 0.01). However, after discontinuation they over 6 years age most detected pathogen was HRV(23.6%), followed by HRSV(16.0%), HMPV(10.8%) HPIV(10.4%). But abolition MP(35.9%), HRV(19.7%), HRSV(17.5%) HPIV (6.6%). Moreover, number rate MP ADV had significantly increased remained a high level (P<0.05). addition, HRSV epidemic season has changed(transitioning winter summer), multiple NPIs (P Withdrawal major measures, disease burden Suzhou sharply increased, mainly attributed MP, mixed common.

Язык: Английский

Процитировано

0
Genetic factors driving the Mycoplasma pneumoniae outbreak among children post-COVID-19 in China: a whole genome analysis DOI
Weiwei Jiao, Jie Wang, Cuidan Li

и другие.

The Lancet Regional Health - Western Pacific, Год журнала: 2025, Номер 59, С. 101578 - 101578

Опубликована: Май 13, 2025

Язык: Английский

Процитировано

0
Wastewater Surveillance Uncovered the Impacts of the Timing of COVID-19 on the Epidemic Trajectories of Other Respiratory Diseases in Two Northeastern Cities in China DOI
Haifeng Li, Ziqiang Zhang, Zhenyu Liu

и другие.

ACS ES&T Water, Год журнала: 2024, Номер 4(9), С. 4083 - 4090

Опубликована: Авг. 14, 2024

In this study, we conducted quantitative polymerase chain reaction (qPCR)-based wastewater surveillance for 12 prominent respiratory pathogens in two northeastern cities of China, Dalian, and Benxi, to understand the cocirculation patterns between COVID-19 other diseases from October 2022 July 2023. Wastewater revealed that Influenza A virus (IAV) syncytial (RSV) sewage concentrations exhibited an upward trend both but with distinct epidemic trajectories. IAV RSV peaked early December, followed by a rapid decline since emergence on November 23, 2022. bell-shaped curves were observed concentrations, peaking mid-December 2022, even though severe acute syndrome coronavirus 2 (SARS-CoV-2) emerged December 8, After SARS-CoV-2 January 2023, new wave occurred February April cities, surge RNA May. Meanwhile, out-of-season March May was Benxi based cities' concentrations. This study highlights impact timing trajectories diseases.

Язык: Английский

Процитировано

1
Immunity Debt Regarding the Aspect of Influenza in the Post-COVID-19 Era in Taiwan DOI Creative Commons

Edward C. Wu,

Victoria H. Wu,

Kang‐Hsi Wu

и другие.

Viruses, Год журнала: 2024, Номер 16(9), С. 1468 - 1468

Опубликована: Сен. 15, 2024

Immunity debt for various viral infections was reported globally in the post-COVID-19 era, but data about influenza are lacking. This study collected from Taiwan’s CDC Open Data Portal. We analyzed weekly number of hospitalizations January 2017 to May 2024. divided period into four phases: pre-COVID-19 without epidemics, with an epidemic, COVID-19 pandemic lockdown control, and unlock periods. The Wilcoxon rank-sum test interrupted time series analysis were used. median case numbers periods 174 (IQR = 98), 431 160), 8, 155 175), respectively. Under hospitalization decreased by 90.2% (p < 0.001). non-pharmaceutical intervention (NPI) policies during helped Taiwan reduce significantly. Till now, a comparison prevalence has yet be reported. In our study, unlocking, it increased 20-fold 0.001), still significantly lower than that pre-COVID-19. Amongst other factors, this may associated continuing self-induced NPIs Taiwan.

Язык: Английский

Процитировано

1
Chest Computed Tomography Radiomics for Determining Macrolide Resistance-Associated Gene Mutation Status in Children with Mycoplasma pneumoniae Pneumonia: A Two-Center Study DOI
Haoru Wang, Leilei Zhao,

Yanlin Yang

и другие.

Academic Radiology, Год журнала: 2024, Номер 31(9), С. 3774 - 3782

Опубликована: Май 20, 2024

Язык: Английский

Процитировано

0