Authorea (Authorea),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
According
to
the
existing
facts,
COVID-19
is
prone
infection
for
a
long
time,
and
attacks
immune
system,
immunity
of
population
continues
decline.
Decreased
has
limit
(immune
deficiency),
which
can
cause
opportunistic
infections,
tumors
other
problems.
In
addition,
myocarditis
neurological
problems
should
not
be
ignored.
this
paper,
we
guess
that
virus
invasion
cells
result
interaction
proteins
on
membrane.
Epidemiology
predicts
symptoms
related
are
follow
by
biased
normal
distribution,
at
bottom,
further
outbreaks
will
occur
in
future.
We
also
mentioned
measures
taken
now
(Promote
detection
immunity,
such
as
CD4
cell
counts).
Emerging Microbes & Infections,
Год журнала:
2024,
Номер
13(1)
Опубликована: Март 18, 2024
After
the
use
of
facemasks,
other
isolation
measures
enacted
during
SARS-CoV-2
pandemic
were
lifted,
respiratory
pathogens,
such
as
RSV,
reappeared,
but
until
November
2023
WHO
alert
for
China,
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 13, 2025
China
has
adhered
to
policies
of
zero-COVID
for
almost
three
years
since
the
outbreak
COVID-19,
which
remarkably
affected
circulation
respiratory
pathogens.
However,
begun
end
in
late
2022.
Here,
we
reported
a
resurgence
common
viruses
and
Mycoplasma
pneumoniae
with
unique
epidemiological
characteristics
among
children
after
ending
policy
Shanghai,
China,
2023.
Children
hospitalized
acute
tract
infections
were
enrolled
from
January
2022
December
Nine
2
atypical
bacteria
detected
specimens
patients
using
multiplex
PCR-based
assay.
The
data
analyzed
compared
between
periods
before
(2022)
(2023)
policies.
A
total
8550
enrolled,
including
6170
2023
2380
Rhinovirus
(14.2%)
was
dominant
pathogen
2022,
however,
(38.8%)
Compared
detection
rates
pathogens
significantly
increased
(72.9%
vs.
41.8%,
p
<
0.001).
An
out‐of-season
epidemic
syncytial
virus
observed
during
spring
summer
median
age
infected
greater
than
that
Besides,
mixed
more
frequent
(23.8%
28.9%,
is
now
facing
multiple
epidemics
changing
seasonality,
altered
distribution,
increasing
infection
Our
finding
highlights
need
public
health
interventions
prepare
outbreaks
post-COVID-19
era.
The Italian Journal of Pediatrics/Italian journal of pediatrics,
Год журнала:
2025,
Номер
51(1)
Опубликована: Янв. 23, 2025
This
study
aimed
to
describe
the
epidemiological
trends
of
Mycoplasma
pneumoniae
(MP)
infection
among
children
with
acute
respiratory
tract
infections
(ARTIs)
before,
during
and
after
COVID-19
pandemic,
evaluating
impact
non-pharmaceutical
interventions
(NPIs)
on
epidemiology
MP
infection.
Children
ARTIs
admitted
Children's
Hospital
Soochow
University
(SCH)
from
January
2010
December
2023
underwent
nucleic
acid
PCR
assay
were
included.
Clinical
data
age,
sex,
onset
time
detection
result
collected
analyzed.
All
122,984
inpatients
enrolled,
in
which
20.8%
(25659/122984)
tested
positive,
including
19.4%
(14139/72662)
for
male
22.9%
(11520/50322)
female.
It
was
a
statistically
significant
difference
between
two
genders
(p
<
0.05).
In
addition,
positive
rate
highest
age
group
>
6
years
old
each
year
During
14-year
period,
has
experienced
four
peaks
2012,
2013,
2019,
2023.
Before
NPIs
prevalence
showed
seasonality,
number
positivity
reached
their
peak
August.
However,
remained
at
low
level
NPIs.
After
abolition
NPIs,
obviously
increased
high
level.
The
could
reduce
spread
change
its
epidemic
season,
but
it
not
changed
susceptible
population
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(12), С. 10211 - 10232
Опубликована: Июнь 13, 2024
Papain-like
protease
(PLpro)
is
a
promising
therapeutic
target
for
its
pivotal
role
in
the
life
cycle
of
SARS-CoV-2.
A
series
1,2,4-oxadiazole
derivatives
was
designed
and
synthesized
via
ring
formation
strategy
based
on
SARS-CoV-2
PLpro-GRL0617
complex
structure.
Systematic
structure-activity
relationship
studies
revealed
that
introducing
oxadiazole
aryl
carboxylic
acid
moieties
to
GRL0617
enhanced
enzymatic
inhibition
activity,
affinity,
deubiquitination
capacity
toward
PLpro.
1,2,4-Oxadiazole
compounds
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Окт. 9, 2024
Background
To
counteract
the
COVID-19
pandemic,
nonpharmaceutical
interventions
(NPIs)
were
implemented
globally,
exerting
a
profound
influence
on
wide
spectrum
of
infectious
diseases,
encompassing
respiratory
tract
infections
(RTIs).
Subsequent
to
easing
NPIs,
China
experienced
significant
outbreak
Mycoplasma
pneumoniae
(MP).
Methods
Over
decade
from
2015
2024,
our
study
scrutinized
12
common
diseases
among
pediatric
children.
Etiologically
diagnostic
data
and
clinical
outcome
metrics
children
with
RTIs,
tested
for
13
pathogens,
analyzed
evaluate
changes
during
after
pandemic
compared
pre-pandemic
periods,
notable
emphasis
age
profile
coinfection
patterns
MP.
Results
Among
57,471
hospitalized
children,
23,178
diagnosed
diseases.
Under
most
declined
levels,
rebounding
by
69.64%
in
2023.
While
infection
rate
pathogens
decreased,
cases
syncytial
virus
increased
period
extensive
NPI
implementation.
In
2023,
intensive
care
unit
durations
these
increased,
suggesting
greater
severity
illness
2019.
MP
exhibited
highest
(31.38%
average),
post-pandemic
due
increase
<3
year
olds
rise
older
NPIs
reduced
coinfections
mitigated
their
severity,
while
bacterial
over
span
5
years,
contrast
impact
viral
pathogens.
Conclusion
effectively
curb
transmission
resulting
average
altered
post-pandemic.
This
study
aimed
to
describe
epidemiological
changes
of
common
respiratory
pathogens
in
children
with
acute
infections
(ARIs)
during
the
different
levels
non-pharmaceutical
interventions(NPIs).
In
this
retrospective
study,
we
analyzed
prevalence
12
from
September
2021
through
February
2024
all
inpatients
ARIs
admitted
Children's
Hospital
Soochow
University(SCH).
We
compared
detection
rates
these
at
public
NPI
measures.
total,
27,851
samples
were
analyzed,
including
15,231
boys
and
12,620
girls.
Under
strict
NPIs,
more
commonly
boy
infants
(p
<
0.01).
However,
after
discontinuation
they
over
6
years
age
most
detected
pathogen
was
HRV(23.6%),
followed
by
HRSV(16.0%),
HMPV(10.8%)
HPIV(10.4%).
But
abolition
MP(35.9%),
HRV(19.7%),
HRSV(17.5%)
HPIV
(6.6%).
Moreover,
number
rate
MP
ADV
had
significantly
increased
remained
a
high
level
(P<0.05).
addition,
HRSV
epidemic
season
has
changed(transitioning
winter
summer),
multiple
NPIs
(P
Withdrawal
major
measures,
disease
burden
Suzhou
sharply
increased,
mainly
attributed
MP,
mixed
common.
ACS ES&T Water,
Год журнала:
2024,
Номер
4(9), С. 4083 - 4090
Опубликована: Авг. 14, 2024
In
this
study,
we
conducted
quantitative
polymerase
chain
reaction
(qPCR)-based
wastewater
surveillance
for
12
prominent
respiratory
pathogens
in
two
northeastern
cities
of
China,
Dalian,
and
Benxi,
to
understand
the
cocirculation
patterns
between
COVID-19
other
diseases
from
October
2022
July
2023.
Wastewater
revealed
that
Influenza
A
virus
(IAV)
syncytial
(RSV)
sewage
concentrations
exhibited
an
upward
trend
both
but
with
distinct
epidemic
trajectories.
IAV
RSV
peaked
early
December,
followed
by
a
rapid
decline
since
emergence
on
November
23,
2022.
bell-shaped
curves
were
observed
concentrations,
peaking
mid-December
2022,
even
though
severe
acute
syndrome
coronavirus
2
(SARS-CoV-2)
emerged
December
8,
After
SARS-CoV-2
January
2023,
new
wave
occurred
February
April
cities,
surge
RNA
May.
Meanwhile,
out-of-season
March
May
was
Benxi
based
cities'
concentrations.
This
study
highlights
impact
timing
trajectories
diseases.
Viruses,
Год журнала:
2024,
Номер
16(9), С. 1468 - 1468
Опубликована: Сен. 15, 2024
Immunity
debt
for
various
viral
infections
was
reported
globally
in
the
post-COVID-19
era,
but
data
about
influenza
are
lacking.
This
study
collected
from
Taiwan’s
CDC
Open
Data
Portal.
We
analyzed
weekly
number
of
hospitalizations
January
2017
to
May
2024.
divided
period
into
four
phases:
pre-COVID-19
without
epidemics,
with
an
epidemic,
COVID-19
pandemic
lockdown
control,
and
unlock
periods.
The
Wilcoxon
rank-sum
test
interrupted
time
series
analysis
were
used.
median
case
numbers
periods
174
(IQR
=
98),
431
160),
8,
155
175),
respectively.
Under
hospitalization
decreased
by
90.2%
(p
<
0.001).
non-pharmaceutical
intervention
(NPI)
policies
during
helped
Taiwan
reduce
significantly.
Till
now,
a
comparison
prevalence
has
yet
be
reported.
In
our
study,
unlocking,
it
increased
20-fold
0.001),
still
significantly
lower
than
that
pre-COVID-19.
Amongst
other
factors,
this
may
associated
continuing
self-induced
NPIs
Taiwan.
