Journal of Medical Virology, Год журнала: 2022, Номер 95(1)
Опубликована: Дек. 13, 2022
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Язык: Английский
Bulletin of the Academy of Sciences of Moldova Medical Sciences, Год журнала: 2024, Номер 77(3), С. 234 - 238
Опубликована: Янв. 1, 2024
Tuberculosis is a serious infectious disease with global impact, causing significant number of deaths each year. It continues to pose major challenge the healthcare system and requires sustained efforts for control prevention. The aim this study was analyze historical aspects tuberculosis outcomes local programs. materials methods involved research specialized literature. main conclusions include evolution tuberculosis, impact discoveries medical advancements on its treatment control, as well ongoing need implement effective prevention strategies.
Язык: Английский
Процитировано
81
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(14), С. 4784 - 4784
Опубликована: Июль 19, 2023
The year 2020 will likely be remembered as the dominated by COVID-19, or coronavirus disease. emergence of severe acute respiratory syndrome 2 (SARS-CoV-2), responsible for this pandemic, can traced back to late 2019 in China. COVID-19 pandemic has significantly impacted tuberculosis (TB) care system, reducing TB testing and reporting. This attributed disruption services restrictions on patient movement, consequently increasing TB-related deaths. perspective review aims highlight intersection between TB, highlighting their dual threat identifying shared solutions address these two infectious diseases effectively. There are several commonalities tuberculosis, particularly transmission causative agents, (SARS-CoV-2) Mycobacterium tuberculosis. Both pathogens transmitted via tract secretions. that through droplets airborne particles, primary target is typically lungs. Regarding diagnostics, methods available rapid accurate detection. These include RT-PCR, which provide results within hours, antigen test kits offer just a few minutes. availability point-of-care self-testing further enhances convenience. On other hand, various approaches employed diagnostics swiftly identify active TB. sputum microscopy, reverse transcription polymerase chain reaction (RT-PCR), chest X-rays. enable detection same day, while culture-based may take longer, ranging from 8 weeks. utilization diverse diagnostic tools helps ensure timely identification management cases. quality life patients affected due nature associated challenges. In conclusion, it crucial emphasize urgent need have devastated global health, convergence poses an even greater challenge. Collaborative efforts, research investments, policy reforms essential tackle
Язык: Английский
Процитировано
26
IJID Regions, Год журнала: 2022, Номер 6, С. 7 - 14
Опубликована: Ноя. 18, 2022
Chronic pulmonary aspergillosis (CPA) may be confused with, or a coinfection of, tuberculosis (PTB), manifest itself after completion of antituberculous therapy (ATT).Literature searches were conducted on PubMed. The selected studies stated the timing CPA diagnosis with respect to PTB. key assumptions for estimating annual incidence, deaths, and 5-year-period prevalence related were: clinically diagnosed PTB patients , 19% those HIV-negative had 7% HIV-positive CPA; percentage presenting in first year developing as ATT finished was 10%; rate development from 2-5 years 1.5%; mortality 20% 1 7.5% thereafter 5.In India, incidence arising 2019 estimated 363 601 cases (range 254 521 - 472 682) 42 766 deaths 29 936-55 595) 10.5% total deaths. at 575 716 an additional 100 715 deaths' range 436- 186 525) annually.The revised estimation indicates substantial unmet need better part complex PTB-related respiratory morbidity burden.
Язык: Английский
Процитировано
37
The Lancet Regional Health - Americas, Год журнала: 2023, Номер 19, С. 100444 - 100444
Опубликована: Фев. 10, 2023
Disruptions in tuberculosis services have been reported around the world since emergence of COVID-19 pandemic. However, pandemic's effect on preventive treatment (TPT) has poorly explored. We compared TPT-notified prescriptions and outcomes before during pandemic Brazil. Retrospective cohort using secondary data from Brazilian TPT information system five cities with over 1000 notifications. The number was analysed 6 months after healthcare workers' training, 2018, to July 2021. proportion by date initiation up end 2020, as most started 2021 were still unknown Joinpoint regression used evaluate trends. 14,014 included, São Paulo (8032) Rio de Janeiro (3187). Compared same epidemiological weeks 2019, prescribed 2020 increased (82%) (14%) decreased Recife (65%), Fortaleza (31%) Manaus (44%). In 2021, however, there a 93% reduction all cities. completed remained constant (median = 74%). Brazil associated dramatic decrease Treatment adherence constant, suggesting that health able keep people but did not perform well providing opportunities for enter care. Efforts are needed expand access TPT. Ministry Science, Technology Innovation, CNPq.
Язык: Английский
Процитировано
22
The Lancet Regional Health - Western Pacific, Год журнала: 2024, Номер 47, С. 101104 - 101104
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
7
International Journal of General Medicine, Год журнала: 2025, Номер Volume 18, С. 627 - 641
Опубликована: Фев. 1, 2025
Background: Tuberculosis (TB) is a major public health issue in Saudi Arabia, particularly impacting the elderly. Immunocompromising conditions, including comorbidities, malignancies, and use of immunosuppressive agents, are risk factors for active TB (ATB). Objective: To analyze clinical estimate mortality drug-resistant cases. Methods: This retrospective study analyzed medical records 12,494 patients at KAUH (2019– 2021), identifying 131 confirmed cases with comprehensive data on demographics, features, diagnostics, outcomes. Data were using SPSS, chi-square logistic regression factors. Statistical significance was determined threshold p < 0.05. In our study, employed to identify significant predictors among patients. The results presented beta coefficients (B) quantify relationship between outcome, along adjusted odds ratio (AOR) provide an interpretable measure strength these associations. Results: Of involved this paper, higher incidence pulmonary observed men under 30 years old. group also showed rate due comorbidities such as renal failure, human immunodeficiency virus (HIV), autoimmune disease. heightened by 69.47% drug susceptibility. Additionally, 19.85% had multidrug-resistant (MDR-TB), 10.69% extensively (XDR-TB). Patients undergoing hemodialysis, those respiratory cancer, diabetes, smoking found have hazard, indicating TB. Conclusion: highlights TB's prevalence resistance KAUH, emphasizing high-risk groups, males young adults. Effective strategies, targeted interventions, future research vital reducing mortality.This examines stability tuberculosis disease presentation dynamic models treated King Abdulaziz University Hospital (KAUH) Jeddah, Arabia. Key findings include:This first across different demographic groups.Males, elderly individuals, cancer patients, or other death from TB.The emphasize need healthcare practices adopt "equilibrium state" method hazard assessment. Incorporating gold-standard approach into treatment plans can help improve control measures reduce TB-related mortality. provides valuable insights improving patient care outcomes, vulnerable groups. Keywords: Tuberculosis, Pulmonary, Risk Factor, Prevalence, Drug Resistance
Язык: Английский
Процитировано
0
Indian Journal of Tuberculosis, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Summary Climate change is likely to exacerbate a range of determinants which drive tuberculosis, the world’s leading infectious disease killer. However, tuberculosis often neglected in wider climate health discussions. Commissioned by World Health Organization, we developed an analytical framework outlining potential causal relationships between and tuberculosis. We drew on existing knowledge determinants, identified are be sensitive effects change, conceptualised mechanistic pathways through this might occur. collated evidence for these literature reviews. Our reviews found no studies directly linking warranting research build action. The available supports existence plausible links highlights need include risk adaptation mitigation programmes, climate-resilient funding response mechanisms. Further urgently needed quantify
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Март 3, 2025
ABSTRACT Tuberculosis (TB) and COVID-19 are leading infectious diseases with high mortality, caused by Mycobacterium tuberculosis ( Mtb ) SARS-CoV-2 (SC2) , respectively. Co-infection is common but often undiagnosed as it challenging to process both pathogens from a single sample. In this study, we present simple efficient method for co-extracting nucleic acids (NA) these two distinct respiratory downstream diagnostic testing. We evaluated three different acid amplification (NAA)-based platforms, LightCycler480 (LC480) qPCR, Qiacuity digital PCR (dPCR), Cytation3 CRISPR-Cas13a-based SHINE-TB/SC2 detection assays. Chelex-100 chelating resin-based boiling preparation was optimized NA extraction saliva sputum. Saliva showed compatibility all sensitivity low 100 CFU/ml (or 2 genomic copies/µl). This worked well sputum using dPCR at 100% (21/21) positivity, though the CRISPR-based SHINE-TB assay more variability inhibitor carry-over, resulting in an 81% positive rate (17/21). Diluting TE buffer (1:1) improved (2/4). Extraction efficiency of our 48%, 62.2%, 86.4% 99.3% concentrations 10 5 4 3 CFU/ml, The dynamic range spiked pooled (N=8) ≥10 methods. Dual-pathogen co-extraction SC2 (10 PFU/ml) CFU/ml) salivary successful CRISPR-Cas13a have developed rapid multi-pathogen testing across platforms believe first protocol co-extract
Язык: Английский
Процитировано
0
BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)
Опубликована: Март 26, 2025
This study included tuberculosis (TB) patients from high-burden Russian regions of Siberia and Far East. We aimed to assess the impact COVID-19 pandemic on genotypic structure Mycobacterium population epidemiology clinical course in TB TB/COVID-19 coinfected patients. A total 456 M. isolates were studied submitted drug susceptibility testing genotyping. The modern Beijing genotype its main epidemic endemic clusters (B0/W148 Central Asian/Russian), ancient sublineage detected by PCR assays targeting specific molecular markers. Non-Beijing spoligotyped compared SITVIT2 database. More than 80% strains belonged genotype. Among strains, genetic B0/W148 Central-Asian/Russian (94–32) accounted for 94.2% pre-pandemic period 96.6% during group, 81.5% group. Moreover, ratio 94–32 was almost 1:1 (49.7:44.4%), pandemic—1.5:1.0 (57.9:38.8%), while shifted favor cluster became 1:2 (31.8:65.9%). In TB/COVID patients, forms chronic (fibrous cavernous TB, tuberculoma) with more active inflammatory destructive-inflammatory reactions (infiltration, dissemination, TB). (without COVID-19-coinfection) effectiveness treatment decreased 20.6% (p = 0.002). increased, likely due predominance less frequently MDR this statistically significant positive correlation shown between detection 94–32-cluster (Q 0.56, p 0.006). Our results are consistent reportedly higher ability (compared 94–32) acquire resistance anti-TB drugs, their increased virulence transmissibility. Thus, seemingly paradoxical, milder who further developed is explained a shift subtypes syndemic interaction two epidemics.
Язык: Английский
Процитировано
0