Cells, Год журнала: 2025, Номер 14(11), С. 842 - 842
Опубликована: Июнь 4, 2025
Brain organoids are self-organized, three-dimensional (3D) aggregates derived from human embryonic stem cells, induced pluripotent or primary organs with cell types and cellular architectures resembling those of the developing brain. Recent studies have shown use region-specific brain for modeling various diseases ranging neurodevelopmental neurodegenerative to different cancers, which numerous applications in fundamental research development new drugs, personalized treatment, regenerative medicine. Consequently, drug discovery is complex challenging still an emerging area this field. This review article summarizes cells used organoid generation, organoids, functional assays their characterization. In addition, we discuss pediatric as well application assembloids, tumoroids cancer neuroscience. We further explore recent advances using high-throughput screening improve discovery.
Язык: Английский