Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver DOI Creative Commons
Aleksandra Aizenshtadt, Chencheng Wang, Shadab Abadpour

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(13)

Опубликована: Янв. 15, 2024

Abstract Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction‐associated steatotic liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing prevalence. While the mechanisms leading to onset development of these conditions not fully understood, predictive tissue representations for studying coordinated interactions between central organs that regulate energy metabolism, particularly pancreatic islets, needed. Here, dual pump‐less recirculating organ‐on‐chip platform combines human pluripotent stem cell (sc)‐derived sc‐liver sc‐islet organoids is presented. The reproduces key aspects cross‐talk both organs, including glucose levels selected hormones, supports viability functionality while preserving reduced release pro‐inflammatory cytokines. In model disruption in response treatment high lipids fructose, exhibit hallmarks steatosis insulin resistance, sc‐islets produce cytokines on‐chip. Finally, known effects anti‐diabetic drugs Taken together, provides basis functional studies T2DM, MASLD on‐chip, as well testing potential therapeutic interventions.

Язык: Английский

Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver DOI Creative Commons
Aleksandra Aizenshtadt, Chencheng Wang, Shadab Abadpour

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(13)

Опубликована: Янв. 15, 2024

Abstract Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction‐associated steatotic liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing prevalence. While the mechanisms leading to onset development of these conditions not fully understood, predictive tissue representations for studying coordinated interactions between central organs that regulate energy metabolism, particularly pancreatic islets, needed. Here, dual pump‐less recirculating organ‐on‐chip platform combines human pluripotent stem cell (sc)‐derived sc‐liver sc‐islet organoids is presented. The reproduces key aspects cross‐talk both organs, including glucose levels selected hormones, supports viability functionality while preserving reduced release pro‐inflammatory cytokines. In model disruption in response treatment high lipids fructose, exhibit hallmarks steatosis insulin resistance, sc‐islets produce cytokines on‐chip. Finally, known effects anti‐diabetic drugs Taken together, provides basis functional studies T2DM, MASLD on‐chip, as well testing potential therapeutic interventions.

Язык: Английский

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