A
bio-based
hydrogel
is
a
complex
compound
that
consists
of
natural
biomaterials
and
widely
applied
for
various
therapeutic
purposes.
The
modification
from
traditional
to
reformulated
hydrogels
has
gained
place
at
biomedical
field
due
the
growth
benefits
such
as
drug
delivery,
tissue
engineering,
regenerative
medicine.
Moreover,
increasing
global
demand
resulted
in
worldwide
shortage
mass
formulations
raised
environmental
awareness.
By
using
instead
synthetic
ones,
these
minimize
their
negative
effects
on
environment
while
simultaneously
maximizing
successful
execution
product.
However,
mechanisms
governing
degradation
bioactivity
hydrogels,
which
dictate
release
profiles,
stability,
effectiveness,
are
not
yet
comprehensively
understood.
Therefore,
by
analyzing
recent
progress
ongoing
challenges,
this
review
will
reveal
how
advanced
quietly
transforming
future
healthcare
offering
novel
solutions
pressing
health
problems.
Gels,
Год журнала:
2024,
Номер
10(9), С. 547 - 547
Опубликована: Авг. 23, 2024
Regenerative
hydrogels
from
natural
polymers
have
come
forth
as
auspicious
materials
for
use
in
regenerative
medicine,
with
interest
attributed
to
their
intrinsic
biodegradability,
biocompatibility,
and
ability
reassemble
the
extracellular
matrix.
This
review
covers
latest
advances
used
wound
healing,
focusing
on
chemical
composition,
cross-linking
mechanisms,
functional
properties.
Key
carbohydrate
polymers,
including
alginate,
chitosan,
hyaluronic
acid,
polysaccharide
gums,
agarose,
carrageenan,
xanthan
gum,
are
discussed
terms
of
sources,
structures
specific
properties
suitable
applications.
The
further
explores
categorization
based
ionic
charge,
response
physiological
stimuli
(i.e.,
pH,
temperature)
particularized
roles
tissue
self-healing.
Various
methods
enhance
mechanical
biological
performance
these
also
examined.
By
highlighting
recent
innovations
ongoing
challenges,
this
article
intends
give
a
detailed
understanding
potential
revolutionize
medicine
improve
patient
healing
outcomes.
Gels,
Год журнала:
2024,
Номер
10(11), С. 693 - 693
Опубликована: Окт. 25, 2024
Hydrogels
are
known
for
their
high
water
retention
capacity
and
biocompatibility
have
become
essential
materials
in
tissue
engineering
drug
delivery
systems.
This
review
explores
recent
advancements
hydrogel
technology,
focusing
on
innovative
types
such
as
self-healing,
tough,
smart,
hybrid
hydrogels,
each
engineered
to
overcome
the
limitations
of
conventional
hydrogels.
Self-healing
hydrogels
can
autonomously
repair
structural
damage,
making
them
well-suited
applications
dynamic
biomedical
environments.
Tough
designed
with
enhanced
mechanical
properties,
enabling
use
load-bearing
cartilage
regeneration.
Smart
respond
external
stimuli,
including
changes
pH,
temperature,
electromagnetic
fields,
ideal
controlled
release
tailored
specific
medical
needs.
Hybrid
made
from
both
natural
synthetic
polymers,
combine
bioactivity
resilience,
which
is
particularly
valuable
complex
tissues.
Despite
these
innovations,
challenges
optimizing
biocompatibility,
adjusting
degradation
rates,
scaling
up
production
remain.
provides
an
in-depth
analysis
emerging
technologies,
highlighting
transformative
potential
while
outlining
future
directions
development
applications.
Gels,
Год журнала:
2024,
Номер
10(10), С. 636 - 636
Опубликована: Сен. 30, 2024
The
innovative
fusion
of
essential
oils
with
hydrogel
engineering
offers
an
optimistic
perspective
for
the
design
and
development
next-generation
materials
incorporating
natural
bioactive
compounds.
This
review
provides
a
comprehensive
overview
latest
advances
in
use
hydrogels
containing
biomedical,
dental,
cosmetic,
food,
food
packaging,
restoration
cultural
heritage
applications.
Polymeric
sources,
methods
obtaining,
cross-linking
techniques,
functional
properties
are
discussed.
unique
characteristics
polymer
agents
highlighted.
These
include
biocompatibility,
nontoxicity,
effective
antibacterial
activity,
control
sustained
prolonged
release
active
substances,
optimal
porosity,
outstanding
cytocompatibility.
Additionally,
specific
distinctive
explored,
along
their
extraction
encapsulation
methods.
advantages
disadvantages
these
also
We
have
considered
limitations
due
to
volatility,
solubility,
environmental
factors,
stability.
importance
loading
hydrogels,
stability,
biological
activity
is
analyzed.
highlights
through
in-depth
analysis,
recent
innovations,
challenges,
future
prospects
encapsulated
potential
multiple
applications
including
biomedicine,
dentistry,
cosmetics,
conservation.
Nanocomposite
hydrogels
(NHs)
have
emerged
as
a
groundbreaking
tool
in
biomedical
applications,
offering
remarkable
versatility
and
efficacy.
Integrating
wide
range
of
nanoparticles,
including
carbon-based,
polymeric,
ceramic,
metallic
nanomaterials,
within
hydrogel
networks
results
nanocomposites
with
superior
properties
tailored
functionalities.
Recent
research
has
highlighted
their
potential
to
address
key
challenges
drug
delivery,
cancer
therapy,
tissue
regeneration,
biosensing,
wound
healing,
outstanding
biocompatibility
bioavailability.
Nanohydrogels
demonstrate
significant
promise
delivery
systems
biological
sensors,
providing
sustained
therapeutic
activity
at
targeted
sites.
This
reduces
the
frequency
administration
minimizes
harmful
side
effects.
In
healthcare
sector,
they
applications
ranging
from
therapy
aesthetic
corrections
are
leading
topic
regeneration
research.
comprehensive
review
Biomedical
Applications
investigates
latest
advancements
NHs,
focusing
on
classification,
unique
properties,
diverse
applications.
By
identifying
future
prospects
existing
gaps,
this
aims
highlight
diagnostic
nanocomposite
technology,
covering
way
for
further
advancement
field.
Molecules,
Год журнала:
2024,
Номер
29(18), С. 4360 - 4360
Опубликована: Сен. 13, 2024
Carboxymethyl
chitosan
(CMCS)
hydrogels
have
been
investigated
in
biomedical
research
because
of
their
versatile
properties
that
make
them
suitable
for
various
medical
applications.
Key
are
especially
valuable
use
include
biocompatibility,
tailored
solid-like
mechanical
characteristics,
biodegradability,
antibacterial
activity,
moisture
retention,
and
pH
stimuli-sensitive
swelling.
These
features
offer
advantages
such
as
enhanced
healing,
promotion
granulation
tissue
formation,
facilitation
neutrophil
migration.
As
a
result,
CMCS
favorable
materials
applications
biopharmaceuticals,
drug
delivery
systems,
wound
engineering,
more.
Understanding
the
interactions
between
biological
with
focus
on
influence
cellular
behavior,
is
crucial
leveraging
versatility.
Because
constantly
growing
interest
its
derivative
applications,
present
review
aims
to
provide
updated
insights
into
potential
based
recent
findings.
Additionally,
we
comprehensively
elucidated
mechanisms
underlying
actions
these
settings.
In
summary,
this
paper
recapitulates
data
gathered
from
current
literature,
offering
perspectives
further
development
utilization
carboxymethyl
contexts.
Gels,
Год журнала:
2025,
Номер
11(2), С. 131 - 131
Опубликована: Фев. 12, 2025
Local
anesthetics
(LAs)
have
been
indispensable
in
clinical
pain
management,
yet
their
limitations,
such
as
short
duration
of
action
and
systemic
toxicity,
necessitate
improved
delivery
strategies.
Hydrogels,
with
biocompatibility,
tunable
properties,
ability
to
modulate
drug
release,
extensively
explored
platforms
for
enhancing
LA
efficacy
safety.
This
narrative
review
explores
the
historical
development
LAs,
physicochemical
applications,
providing
a
foundation
understanding
integration
hydrogels
anesthetic
delivery.
Advances
thermoresponsive,
stimuli-responsive,
multifunctional
demonstrated
significant
potential
prolonging
analgesia
reducing
exposure
preclinical
studies,
while
early
findings
highlight
feasibility
thermoresponsive
hydrogel
formulations.
Despite
these
advancements,
challenges
burst
mechanical
instability,
regulatory
considerations
remain
critical
barriers
translation.
Emerging
innovations,
including
nanocomposite
hydrogels,
biofunctionalized
matrices,
smart
materials,
offer
solutions
limitations.
Future
research
should
focus
on
optimizing
formulations,
expanding
validation,
integrating
advanced
fabrication
technologies
3D
printing
artificial
intelligence-driven
design
enhance
personalized
management.
By
bridging
materials
science
pharmacology,
this
provides
comprehensive
perspective
current
trends
future
directions
hydrogel-based
systems.
Gels,
Год журнала:
2025,
Номер
11(4), С. 234 - 234
Опубликована: Март 23, 2025
Interest
in
developing
new,
effective
materials
for
emergency
hemostasis
and
wound
healing
is
steadily
increasing,
particularly
use
emergency,
surgical,
military
situations.
Hydrogels,
with
their
unique
retention,
swelling,
biocompatibility
properties,
have
emerged
as
essential
therapy.
This
review
provides
a
comprehensive
examination
of
recent
hydrogel
applications
acute
medical
scenarios,
including
hemostasis,
management,
drug
delivery,
soft
tissue
replacement,
engineering.
We
discuss
the
physicochemical
properties
that
make
hydrogels
suitable
rapid
response
situations,
such
tunable
mechanical
strength,
adhesiveness,
responsiveness
to
environmental
stimuli,
ability
encapsulate
release
therapeutic
agents.
Additionally,
article
explores
advancements
smart
self-healing
antimicrobial
providing
insights
into
potential
revolutionize
care
increase
survival
rates
both
civilian
applications.
Through
critical
evaluation
current
clinical
trials
practical
deployments,
this
highlights
successes
challenges
faced
integrating
protocols,
roadmap
future
research
development
dynamic
field.
Materials,
Год журнала:
2025,
Номер
18(11), С. 2576 - 2576
Опубликована: Май 31, 2025
Cartilage
tissue
engineering
(CTE)
is
an
advancing
field
focused
on
developing
biomimetic
scaffolds
to
overcome
cartilage’s
inherently
limited
self-repair
capacity.
Smart
hydrogels
(SHs)
have
gained
prominence
among
the
various
scaffold
materials
due
their
ability
modulate
cellular
behavior
through
tunable
mechanical
and
biochemical
properties.
These
respond
dynamically
external
stimuli,
offering
precise
control
over
biological
processes
facilitating
targeted
regeneration.
Recent
advances
in
fabrication
technologies
enabled
design
of
SHs
with
sophisticated
architecture,
improved
strength,
enhanced
biointegration.
Key
features
such
as
injectability,
controlled
biodegradability,
stimulus-dependent
release
biomolecules
make
them
particularly
suitable
for
regenerative
applications.
The
incorporation
nanoparticles
further
improves
performance
delivery
capability.
In
addition,
shape
memory
self-healing
properties
contribute
scaffolds’
resilience
adaptability
dynamic
physiological
environments.
An
emerging
innovation
this
area
integrating
artificial
intelligence
(AI)
omics-based
approaches
that
enable
high-resolution
profiling
responses
engineered
hydrogels.
data-driven
tools
support
rational
optimization
hydrogel
systems
allow
development
more
effective
personalized
scaffolds.
convergence
smart
omics
insights
represents
a
transformative
step
medicine
offers
promising
strategies
restoring
cartilage
function.
Gels,
Год журнала:
2024,
Номер
10(8), С. 508 - 508
Опубликована: Авг. 1, 2024
Stem
cell-based
therapy
holds
promise
for
cartilage
regeneration
in
treating
knee
osteoarthritis
(KOA).
Injectable
hydrogels
have
been
developed
to
mimic
the
extracellular
matrix
(ECM)
and
facilitate
stem
cell
growth,
proliferation,
differentiation.
However,
these
face
limitations
such
as
poor
mechanical
strength,
inadequate
biocompatibility,
suboptimal
biodegradability,
collectively
hindering
their
effectiveness
regeneration.
This
study
introduces
an
injectable,
biodegradable,
self-healing
hydrogel
composed
of
chitosan–PEG
PEG–dialdehyde
delivery.
can
form
situ
by
blending
two
polymer
solutions
through
injection
at
physiological
temperature,
encapsulating
human
adipose-derived
cells
(hADSCs)
during
gelation
process.
Featuring
a
3D
porous
structure
with
large
pore
size,
optimal
properties,
easy
injectability,
rapid
capability,
supports
differentiation
hADSCs.
Notably,
encapsulated
hADSCs
spheroids
sizes
increasing
over
time
alongside
degradation
while
maintaining
high
viability
least
10
days.
Additionally,
this
exhibit
upregulated
expression
chondrogenic
genes
proteins
compared
those
cultured
on
2D
surfaces.
These
characteristics
make
chitosan–PEG/PEG–dialdehyde
hydrogel–stem
construct
suitable
direct
implantation
minimally
invasive
injection,
enhancing
KOA
other
treatments.
