Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications DOI Open Access
Andrew Goulian,

Barry Goldstein,

Maarouf Saad

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(6), С. 2061 - 2061

Опубликована: Март 18, 2025

Background/Objectives: Regenerative therapies have gained interest in orthopedic applications for their potential to enhance tissue regeneration, functional recovery, and pain modification. This review evaluates the clinical efficacy of platelet-rich plasma (PRP), mesenchymal stem cells (MSCs), peptide-based treatments, biomimetic materials care, with a focus on reduction outcomes. Methods: A structured literature search PubMed (January 2009–January 2025) identified 160 studies. After applying inclusion criteria prioritizing randomized controlled trials (RCTs) trials, 59 studies were included: 20 PRP, MSCs, 10 peptide therapies, 7 biomimetics. Data extraction focused risk bias assessed using Cochrane Risk Bias (RoB) tool ROBINS-I tool. random-effects meta-regression analysis was conducted evaluate impact therapy type, sample size, reported Results: Meta-regression MSC as most effective intervention (β = 8.45, p < 0.05), PRP showing moderate improvements, demonstrating lowest effect. provided short-term relief, particularly acute injuries tendon repair, though inconsistencies preparation methods limited success chronic conditions. demonstrated cartilage regeneration early osteoarthritis improvement, but high costs ethical concerns remain barriers widespread adoption. Peptide-based materials, including engineered scaffolds autologous protein solutions, showed promise infection control wound healing, further research is needed optimize dosing, delivery methods, long-term safety. Conclusions: offer significant reliable regenerative effects, providing symptomatic treatments emerging promising adjuncts. However, standardized protocols large-scale are establish improve translation broader

Язык: Английский

Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications DOI Open Access
Andrew Goulian,

Barry Goldstein,

Maarouf Saad

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(6), С. 2061 - 2061

Опубликована: Март 18, 2025

Background/Objectives: Regenerative therapies have gained interest in orthopedic applications for their potential to enhance tissue regeneration, functional recovery, and pain modification. This review evaluates the clinical efficacy of platelet-rich plasma (PRP), mesenchymal stem cells (MSCs), peptide-based treatments, biomimetic materials care, with a focus on reduction outcomes. Methods: A structured literature search PubMed (January 2009–January 2025) identified 160 studies. After applying inclusion criteria prioritizing randomized controlled trials (RCTs) trials, 59 studies were included: 20 PRP, MSCs, 10 peptide therapies, 7 biomimetics. Data extraction focused risk bias assessed using Cochrane Risk Bias (RoB) tool ROBINS-I tool. random-effects meta-regression analysis was conducted evaluate impact therapy type, sample size, reported Results: Meta-regression MSC as most effective intervention (β = 8.45, p < 0.05), PRP showing moderate improvements, demonstrating lowest effect. provided short-term relief, particularly acute injuries tendon repair, though inconsistencies preparation methods limited success chronic conditions. demonstrated cartilage regeneration early osteoarthritis improvement, but high costs ethical concerns remain barriers widespread adoption. Peptide-based materials, including engineered scaffolds autologous protein solutions, showed promise infection control wound healing, further research is needed optimize dosing, delivery methods, long-term safety. Conclusions: offer significant reliable regenerative effects, providing symptomatic treatments emerging promising adjuncts. However, standardized protocols large-scale are establish improve translation broader

Язык: Английский

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