Microneedle Array‐Based Dermal Interstitial Fluid Biopsy for Cancer Diagnosis: Advances and Challenges

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Abstract Current early cancer diagnostic technologies, such as imaging, molecular tests, endoscopic techniques, and biopsies, face considerable challenges in low‐and middle‐income countries (LMICs) due to high costs, procedural complexity, limited resource access. Microneedle‐based liquid biopsy for skin interstitial fluid (ISF) offers a practical minimally invasive alternative diagnosis these settings. This review systematically examines ISF methods their effectiveness capturing biomarkers directly from the assesses potential address needs low‐resource environments. Recent innovations microneedle design underscore enabling early, accessible detection tailored LMICs' needs. Additionally, integrating artificial intelligence (AI) data interpretation is proposed way enhance accuracy enable real‐time point‐of‐care (POC) applications. Collectively, advances illustrate flexible, scalable model diagnostics, with significant implications improving healthcare quality resource‐limited

Язык: Английский

Genetic polymorphism and current biotechnology approaches of therapeutic aspects within endometrial tumors

Опубликована: Фев. 24, 2025

Among oncological diseases of women, gynecological deserve special attention. Gynecological tumors are important to women's health throughout the world. Notably, gynecologic malignancies represent a prevalent category cancers affecting women globally. Single nucleotide polymorphisms have emerged as promising source genetic information better understand complex such cancer, in terms etiology, interindividual differences and treatment response. In this review, we summarize some selected gene single polymorphisms’ implication cancer susceptibility/predisposition, well potential use markers for improved diagnosis individualized cancers. Furthermore, review explores advances biotechnology that contributed management tumors, particular endometrial with focus on molecular diagnostics, therapeutic innovations, personalized medicine. It is critical investigate sociated susceptibility/predisposition them might be utilized useful assessing predisposition further used modalities individuals similar polymorphism profile. Moreover, recent advancements biosensing technologies, particularly nano-biosensors microfluidic biosensors, significantly enhanced detection tumor markers. Taken together, revolution research, diagnosis, has been made possible by decades.

Язык: Английский

Advancing gut microbiome insights: Graphene quantum dot nanobiosensors for microbial metabolite detection

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162954 - 162954

Опубликована: Апрель 1, 2025