Bioactive Materials, Год журнала: 2024, Номер 46, С. 259 - 272
Опубликована: Дек. 24, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101653 - 101653
Опубликована: Март 12, 2025
Skeletal muscle regeneration is a complex process that depends on the interplay between immune responses and stem cell (MuSC) activity. Macrophages play crucial role in this process, exhibiting distinct polarization states-M1 (pro-inflammatory) M2 (anti-inflammatory)-that significantly affect tissue repair outcomes. Recent advancements nanomedicine have positioned gold nanoparticles (Au NPs) as promising tools for modulating macrophage enhancing regeneration. This review examines of Au NPs influencing behavior, focusing their physicochemical properties, biocompatibility, mechanisms action. We discuss how can promote polarization, facilitating through modulation cytokine production, interaction with surface receptors, activation intracellular signaling pathways. Additionally, we highlight benefits MuSC function, angiogenesis, extracellular matrix remodeling. Despite potential skeletal regeneration, challenges remain optimizing nanoparticle design, developing targeted delivery systems, understanding long-term effects. Future directions should focus personalized medicine approaches combination therapies to enhance therapeutic efficacy. Ultimately, emphasizes transformative regenerative medicine, offering hope improved treatments injuries diseases.
Язык: Английский
Процитировано
1
The Innovation Life, Год журнала: 2024, Номер unknown, С. 100105 - 100105
Опубликована: Янв. 1, 2024
<p>Artificial intelligence has had a profound impact on life sciences. This review discusses the application, challenges, and future development directions of artificial in various branches sciences, including zoology, plant science, microbiology, biochemistry, molecular biology, cell developmental genetics, neuroscience, psychology, pharmacology, clinical medicine, biomaterials, ecology, environmental science. It elaborates important roles aspects such as behavior monitoring, population dynamic prediction, microorganism identification, disease detection. At same time, it points out challenges faced by application data quality, black-box problems, ethical concerns. The are prospected from technological innovation interdisciplinary cooperation. integration Bio-Technologies (BT) Information-Technologies (IT) will transform biomedical research into AI for Science paradigm.</p>
Язык: Английский
Процитировано
5
Bioactive Materials, Год журнала: 2025, Номер 46, С. 503 - 515
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160620 - 160620
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101628 - 101628
Опубликована: Март 2, 2025
Various pathological conditions (e.g., diabetes, osteoporosis) are accompanied by persistent oxidative stress, which compromises the immune microenvironment and poses substantial challenges for osseointegration. Reactive oxygen species (ROS) play a "double-edged sword" role in bone tissue. Therefore, developing responsive biomaterials to maintain redox balance dynamically is crucial enhanced Herein, microenvironment-responsive coordination nanoparticles (C-Ca-SalB NPs) composed of salvianolic acid B (SalB), catechol-conjugated chitosan (CS-C), Ca2+ constructed further covalently immobilized onto titanium implant surfaces. The resulting implants achieve on-demand antioxidant immunomodulatory effects manner, thus facilitating regeneration under both normal conditions. Under physiological conditions, functionalized display modest properties without affecting balance, while C-Ca-SalB NPs remain relatively stable. However, modified enable rapid decomposition acidic displaying robust ROS-scavenging, anti-inflammatory, osteoinductive capacities, ultimately remodeling into regenerative one. Overall, smart with controlled bioactive agent release this study present comprehensive solution enhancing bone-implant integration, particularly challenging context stress.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 307, С. 141577 - 141577
Опубликована: Март 5, 2025
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Апрель 7, 2025
Abstract The ordered topological micro/nanostructures of scaffolds play a pivotal role in regulating bone development, remodeling, and regeneration. Nevertheless, achieving the integration into 3D remains formidable challenge. In this context, brushing‐assembly strategy is developed to construct bioactive with highly micro/nanostructures. Such an engineered scaffold exhibits positive regulatory effect on behavior fate resident cells, such as mesenchymal stem cells (MSCs) human umbilical vein endothelial (HUVECs), through mechanical stimulation provided by micro/nanostructures, while also allowing for precise spatial distribution multiple cell types assembly. vivo experiments demonstrate that nanostructures possess potential accelerate vascularized Overall, work proposed universal fabrication bridging gap between surface microstructures tissue engineering.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(37), С. 9375 - 9389
Опубликована: Янв. 1, 2024
The 3D printed scaffolds constructed from polymers have shown significant potential in the field of bone defect regeneration. However, efficacy these can be markedly reduced certain pathological conditions like diabetes, where an altered inflammatory microenvironment and diminished small blood vessels complicate integration with host tissue. In this study, bioactivity a 3D-printed poly(lactide-
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
Abstract The demand for systemic treatment of osteoporotic fractures to reduce recurrence is increasing, but current anti‐osteoporosis medications exhibit unsatisfactory efficacy due adverse events and limited effects on fracture healing. Herein, a bone‐targeting zeolitic imidazolate framework‐8 (ZIF)‐based hydrogen sulfide (H 2 S) delivery system (ZIF‐H S‐SDSSD) designed simultaneously promote healing alleviate osteoporosis. With peptide SDSSD grafted the surface, ZIF‐H S‐SDSSD nanoparticles release H S in bone tissues without affecting serum level, thereby mitigating potential risks systematic delivery. Upon cellular uptake, acidic environment lysosomes drives from encapsulated zinc conjunction with degradation ZIF. synergistic released Zn 2+ macrophage metabolic reprogramming by suppressing succinate accumulation mitochondrial reactive oxygen species (mtROS) production, further regulate osteoblast‐osteoclast coupling. Overall, this strategy holds great promise clinical broadens application nanomedicine therapy orthopedic diseases.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2024, Номер 46, С. 259 - 272
Опубликована: Дек. 24, 2024
Язык: Английский
Процитировано
0