Nanoformulation of the Photoactive Cisplatin Prodrug for Combined Photothermal Therapy and Bioimaging DOI
Daniil Viktorovich Spector,

Vladislav Bykusov,

A. Zharova

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(22), С. 25603 - 25618

Опубликована: Ноя. 8, 2024

Cancer phototheranostics is a new mode of precise treatment based on fluorescent and photothermal imaging (PTI), combined with photodynamic (PDT) therapy (PTT). Herein, we designed photoactive Pt(IV) prodrug Pt-1 BODIPY-based triplet photosensitizer as an axial ligand that exhibits cytotoxic effects through both PDT photoactivated chemotherapy (PACT). Based the prodrug, developed multifunctional theranostic nanoplatform Pt-NPs PDT/PTT activity, capable light-induced cisplatin release suitable for tumor imaging. Upon 660 nm laser irradiation, efficiently causes regional hyperpyrexia, conversion efficiency 42.1%. Synergistically, acts type I agent. In vivo PTI studies have shown bright fluorescence CT-26 after intravenous injection Pt-NPs, indicating accumulation retention in tumor. This first example PTT/PDT-active NPs photoinduced cisplatin. strategy synergistic PDT/PTT/PACT action provides platform future design phototheranostic agents enhanced

Язык: Английский

Novel platinum(IV) prodrugs with tetraacetylriboflavin axial ligand possessing enhanced light-induced toxicity DOI
Daniil Viktorovich Spector, Roman Akasov, Dmitrii M. Mazur

и другие.

Mendeleev Communications, Год журнала: 2025, Номер 35(3), С. 282 - 284

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Nanoformulation of the Photoactive Cisplatin Prodrug for Combined Photothermal Therapy and Bioimaging DOI
Daniil Viktorovich Spector,

Vladislav Bykusov,

A. Zharova

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(22), С. 25603 - 25618

Опубликована: Ноя. 8, 2024

Cancer phototheranostics is a new mode of precise treatment based on fluorescent and photothermal imaging (PTI), combined with photodynamic (PDT) therapy (PTT). Herein, we designed photoactive Pt(IV) prodrug Pt-1 BODIPY-based triplet photosensitizer as an axial ligand that exhibits cytotoxic effects through both PDT photoactivated chemotherapy (PACT). Based the prodrug, developed multifunctional theranostic nanoplatform Pt-NPs PDT/PTT activity, capable light-induced cisplatin release suitable for tumor imaging. Upon 660 nm laser irradiation, efficiently causes regional hyperpyrexia, conversion efficiency 42.1%. Synergistically, acts type I agent. In vivo PTI studies have shown bright fluorescence CT-26 after intravenous injection Pt-NPs, indicating accumulation retention in tumor. This first example PTT/PDT-active NPs photoinduced cisplatin. strategy synergistic PDT/PTT/PACT action provides platform future design phototheranostic agents enhanced

Язык: Английский

Процитировано

0