Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(42), С. 8579 - 8583
Опубликована: Янв. 1, 2023
Tuning the electronic structure of protecting groups on nitrogen atom substrates has emerged as an effective strategy to achieve tandem trifluoromethylation/C(sp2)-H annulation using Langlois' reagent CF3 source for electrochemical synthesis functionalized tetrahydroquinolines and dihydroquinolinones.
Язык: Английский
Chemical Reviews, Год журнала: 2022, Номер 122(24), С. 17479 - 17646
Опубликована: Окт. 14, 2022
Alkenes and their derivatives are featured widely in a variety of natural products, pharmaceuticals, advanced materials. Significant efforts have been made toward the development new practical methods to access this important class compounds by selectively activating alkenyl C(sp2)–H bonds recent years. In comprehensive review, we describe state-of-the-art strategies for direct functionalization sp2 C–H C–F until June 2022. Moreover, metal-free, photoredox, electrochemical also covered. For clarity, review has divided into two parts; first part focuses on currently available using different alkene as starting materials, second describes bond easily accessible gem-difluoroalkenes material. This includes scope, limitations, mechanistic studies, stereoselective control (using directing groups well metal-migration strategies), applications complex molecule synthesis where appropriate. Overall, aims document considerable advancements, current status, emerging work critically summarizing contributions researchers working fascinating area is expected stimulate novel, innovative, broadly applicable functionalizations coming
Язык: Английский
Процитировано
155
Organic Chemistry Frontiers, Год журнала: 2023, Номер 11(3), С. 954 - 1014
Опубликована: Дек. 14, 2023
The review summarises various photo- and electrochemical strategies for trifluoromethylation fluoroalkylation of different C(sp 3 )–H, 2 C(sp)–H bonds in several classes organic molecules.
Язык: Английский
Процитировано
14
Green Chemistry, Год журнала: 2022, Номер 24(17), С. 6556 - 6561
Опубликована: Янв. 1, 2022
An electrochemical oxidative thio(seleno)cyanation of enamides to synthesize various ( E )-β-thio(seleno)cyanated enamide compounds is reported herein.
Язык: Английский
Процитировано
17
Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(5), С. 1283 - 1288
Опубликована: Янв. 1, 2023
An environmentally friendly electrochemical fluorotrifluoromethylation of styrenes is developed using CF 3 SO 2 Na and Et N·3HF as the F-containing donor reagents. This synthetic strategy features step economy sustainability.
Язык: Английский
Процитировано
10
The Chemical Record, Год журнала: 2022, Номер 23(1)
Опубликована: Сен. 20, 2022
Abstract Isocyanides are well‐known as efficient CO surrogates and C1 synthons in modern organic synthesis. Although tremendous efforts have been devoted to fully exploiting the reactivity of isocyanides, these transformations primarily limited by their utilization stoichiometric toxic chemical oxidants. With recent resurgence electrochemistry, which has considerably laid dormant over past several decades, electrolysis identified a green powerful tool enrich structural diversity solely utilizing electric current clean inherently safe redox equivalents In this regard, unique isocyanides studied numerous electrochemical transformations. This review comprehensively highlights most relevant progress strategies towards functionalization up until June 2022, with focus on reaction outcomes mechanisms.
Язык: Английский
Процитировано
15
Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(42), С. 8579 - 8583
Опубликована: Янв. 1, 2023
Tuning the electronic structure of protecting groups on nitrogen atom substrates has emerged as an effective strategy to achieve tandem trifluoromethylation/C(sp2)-H annulation using Langlois' reagent CF3 source for electrochemical synthesis functionalized tetrahydroquinolines and dihydroquinolinones.
Язык: Английский
Процитировано
2