Comprehensive Review of Dihydro‐2H‐pyrrol‐2‐one Derivatives
ChemistrySelect,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 1, 2025
Abstract
Heterocyclic
chemistry
has
emerged
as
a
significant
field
with
diverse
applications
in
recent
scenarios.
Nitrogen‐containing
heterocyclic
compounds
have
garnered
attention
due
to
their
unique
physiological
characteristics
and
extensive
medicinal
utility.
Therefore,
the
dihydro‐2
H
‐pyrrol‐2‐one
scaffold
is
key
skeleton
for
pharmaceutical
research
its
high
bioavailability
wider
synthetic
applications.
This
study
found
that
1,5‐dihydro‐2
scaffolds
can
be
used
many
ways.
Thus,
these
been
subject
of
lot
years,
but
preparation
main
core
harder
because
structure.
covers
methods
over
past
15
years
synthesize
substituted
derivatives
through
variety
reaction
approaches
by
utilizing
hybrid
catalyzing
systems,
including
photocatalysis,
electrocatalysis,
alkaline
catalysts,
acid
organocatalysts,
ionic
liquid
nanocatalysts,
heterogeneous
or
homogeneous
transitional‐metal
catalysis
(including
Cu,
Pd,
Ni,
Ru,
Co,
Fe,
Si,
Pt,
Zn,
etc.),
well
mechanism.
review
will
encourage
researchers
exploit
catalytic
synthesis
target
compounds.
Язык: Английский
Solvent-involved synthesis of pyrrolidin-5-one-2-carboxamides via a sequential Ugi/olefination reaction
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(10), С. 2780 - 2785
Опубликована: Янв. 1, 2024
An
unprecedented
multi-component
reaction
with
solvent
participation
and
a
novel
conversion
of
sulfur
ylides
was
developed
via
Ugi/olefination
to
construct
pyrrolidin-5-one-2-carboxamides.
Язык: Английский
Skeletal and Mechanistic Diversity in Ir‐Catalyzed Cycloisomerizations of Allene‐Tethered Pyrroles and Indoles
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(36)
Опубликована: Июнь 5, 2024
Pyrroles
and
indoles
bearing
N-allenyl
tethers
participate
in
a
variety
of
iridium-catalyzed
cycloisomerization
processes
initiated
by
C-H
activation
step,
to
deliver
diversity
synthetically
relevant
azaheterocyclic
products.
By
appropriate
selection
the
ancillary
ligand
substitution
pattern
allene,
reactions
can
diverge
from
simple
intramolecular
hydrocarbonations
tandem
involving
intriguing
mechanistic
issues.
Accordingly,
wide
range
heterocyclic
structures
ranging
dihydro-indolizines
pyridoindoles
tetrahydroindolizines,
as
well
cyclopropane-fused
tetrahydroindolizines
be
obtained.
Moreover,
using
chiral
ligands,
these
cascade
carried
out
an
enantioselective
manner.
DFT
studies
provide
insights
into
underlying
mechanisms
justify
observed
chemo-
regio-
stereoselectivities.
Язык: Английский
Skeletal and Mechanistic Diversity in Ir‐Catalyzed Cycloisomerizations of Allene‐Tethered Pyrroles and Indoles
Angewandte Chemie,
Год журнала:
2024,
Номер
136(36)
Опубликована: Июнь 5, 2024
Abstract
Pyrroles
and
indoles
bearing
N
‐allenyl
tethers
participate
in
a
variety
of
iridium‐catalyzed
cycloisomerization
processes
initiated
by
C−H
activation
step,
to
deliver
diversity
synthetically
relevant
azaheterocyclic
products.
By
appropriate
selection
the
ancillary
ligand
substitution
pattern
allene,
reactions
can
diverge
from
simple
intramolecular
hydrocarbonations
tandem
involving
intriguing
mechanistic
issues.
Accordingly,
wide
range
heterocyclic
structures
ranging
dihydro‐indolizines
pyridoindoles
tetrahydroindolizines,
as
well
cyclopropane‐fused
tetrahydroindolizines
be
obtained.
Moreover,
using
chiral
ligands,
these
cascade
carried
out
an
enantioselective
manner.
DFT
studies
provide
insights
into
underlying
mechanisms
justify
observed
chemo‐
regio‐
stereoselectivities.
Язык: Английский