The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(14), С. 9853 - 9860
Опубликована: Июнь 1, 2024
An
efficient
and
chemodivergent
synthesis
of
highly
functionalized
1,4-dihydropyridazines
pyrazoles
has
been
accomplished
via
base-promoted
annulation
between
hydrazones
alkyl
2-aroyl-1-chlorocyclopropanecarboxylates,
respectively.
This
transition-metal-free
domino
reaction
proceeded
rapidly
under
mild
basic
conditions,
affording
potentially
bioactive
1,4-dihydropyridazine
pyrazole
derivatives
in
moderate
yields.
The
conversion
to
was
confirmed
by
adjusting
the
quantity
base.
Green Chemistry,
Год журнала:
2023,
Номер
25(14), С. 5539 - 5542
Опубликована: Янв. 1, 2023
With
formaldehyde
as
an
atom-economical
carbonyl
synthon,
the
EtOH-catalyzed
electrochemical
multicomponent
synthesis
of
various
imidazolidine-fused
sulfamidates
under
organic
oxidant-free,
energy-saving
and
mild
conditions
was
developed.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
90(4), С. 1683 - 1696
Опубликована: Янв. 17, 2025
In
the
vanguard
of
sustainable
chemistry,
pursuit
efficient
pathways
for
synthesis
alkyl
bicyclo[1.1.1]pentane-heteroaryls
has
captured
attention
scientific
vanguard.
We
herein
report
a
groundbreaking
and
eco-conscious
multicomponent
coupling
reaction
that
paves
way
alkylation
heteroarylation
[1.1.1]propellane,
process
uniquely
enabled
by
photochemical
prowess
an
electron
donor–acceptor
(EDA)
complex.
This
method
is
distinguished
its
minimalist
yet
powerful
approach:
devoid
transition
metals,
additives,
photosensitizers.
Its
universality
further
exemplified
seamless
compatibility
broad
spectrum
halides
heteroarenes
under
standardized
conditions,
heralding
new
era
synthetic
versatility.
The
method's
practicality
underscored
capacity
late-stage
modification
pharmaceuticals,
offering
transformative
tool
enhancement
existing
drug
molecules.
Moreover,
facile
derivatization
synthesized
products
underscores
adaptability
potential
diverse
applications.
Our
mechanistic
studies
have
elucidated
underlying
radical-relay
pathway,
pinpointing
pivotal
role
EDA
complex
in
initiating
transformation.
discovery
not
only
enriches
our
fundamental
understanding
but
also
opens
avenues
strategic
optimization.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
In
this
study,
a
novel
approach
that
combines
photoinduced
electron
transfer
(ET)
with
hydrogen
atom
(HAT)
has
been
introduced
for
the
selective
β-C(sp3)–H
pyridination
of
carbonyl
compounds.
This
method
is
notable
its
absence
transition
metals
and
ability
to
function
under
benign
reaction
conditions,
resulting
in
range
pyridinated
derivatives
consistently
moderate
good
yields.
The
significance
technique
further
underscored
by
potential
late-stage
functionalization
pharmaceutically
significant
molecules.
Mechanistic
investigations
confirmed
proceeds
via
radical-mediated
pathway.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(8)
Опубликована: Июль 20, 2023
Abstract
In
terms
of
pharmaceuticals
and
biological
applications,
synthesis
complex
organic
molecules
is
a
significant
fast‐developing
area.
this
context,
electrosynthesis
an
alternative
way
to
the
traditional
methods
for
chemo‐,
regio‐,
stereoselective
syntheses.
Electro‐organic
reactions
occur
at
room
temperature
normal
pressure,
through
transferring
electrons.
It
has
been
found
that
mild
approach
preparing
electrophilic
substrates,
bases,
nucleophiles
in
situ
,
from
highly
stable
low‐level
reagents;
which
can
be
further
applied
make
heterocycles
more
accessible.
While
several
promising
exist,
multi‐component
(MCRs)
have
drawn
much
attention
both
academia
industry
worldwide,
since
they
are
cost‐efficient
environmentally
friendly.
Combining
MCRs
produced
great
strategy
field
research.
This
review
focuses
on
recent
advances
electrochemical
heterocyclic
compounds
via
reactions,
reported
between
2015
March
2023.
Organic Letters,
Год журнала:
2024,
Номер
26(33), С. 7060 - 7065
Опубликована: Авг. 13, 2024
Bicyclo[1.1.1]pentane
(BCP)
heteroaryls
make
up
an
important
class
of
BCP
derivatives
in
drug
discovery.
Herein,
we
report
the
visible-light-mediated
synthesis
cyanoisopropyl
BCP-heteroaryls
motifs
from
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
study
describes
a
pioneering
visible-light-induced
phosphine-catalyzed
halogen-atom
transfer
(XAT)
strategy
that
heralds
new
era
in
the
difunctionalization
of
[1.1.1]propellane.
A
green
and
practical
method
for
the
electrochemical
synthesis
of
tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones
through
three-component
reaction
quinoxalin-2(1H)-ones,
N-arylglycines
paraformaldehyde
was
reported.
In
this
strategy,
EtOH
played
dual
roles
(eco-friendly
solvent
waste-free
pre-catalyst)
in
situ
generated
ethoxide
promoted
triple
sequential
deprotonations.
