Pd-IPent-Catalyzed Defluorinative Annulation of gem-Difluorocyclopropanes with Enamides: Synthesis of Multisubstituted N-H Pyrroles

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

We present a Pd-IPent-catalyzed ring-opening defluorinative annulation reaction of gem-difluorocyclopropanes with enamides, which provides convenient and efficient strategy for the synthesis multisubstituted N-H pyrrole derivatives. This transformation selectively cleaves C1-C3 bond, two C-F bonds, C-N bond in one-pot procedure. Additionally, this protocol allows modification several bioactive molecules.

Язык: Английский

Palladium-catalyzed ring-opening defluorinative cross-coupling of gem-difluorocyclopropanes with fluoromalonates or fluorobis(phenylsulfonyl)methane

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111288 - 111288

Опубликована: Май 1, 2025

Язык: Английский

Palladium-catalyzed Ring-Opening/Defluorinative Coupling of gem-DFCPs with Pyranones/Pyridones

Tetrahedron, Год журнала: 2024, Номер unknown, С. 134271 - 134271

Опубликована: Сен. 1, 2024

Язык: Английский