Copper-Catalyzed Regioselective 1,4-Sulfonyl Indolylation of 1,3-Dienes with Sulfonyl Chloride and Indoles
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 22, 2025
A
copper-based
catalytic
system
has
been
described
to
enable
the
efficient
1,4-sulfonylindolylation
of
1,3-dienes
with
sulfonyl
chloride
and
indoles.
This
protocol
offers
a
practical
method
for
synthesis
allylsulfone-containing
indole
derivatives
broad
range
compatible
functionalities
excellent
chemo-
regioselectivities.
Mechanistic
studies
suggest
that
copper
catalyst
plays
dual
role
initiating
radicals
prompting
coupling
in
this
conjugated
diene-selective
1,4-difunctionalization
strategy.
Язык: Английский
Nickel-Catalyzed Regioselective Ring-Opening Hydroarylation of Methylenecyclopropanes
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
The
hydroarylation
of
methylenecyclopropanes
(MCPs)
is
a
challenging
process
due
to
the
difficulty
in
controlling
regioselectivity
and
complex
reaction
patterns
involved.
Herein,
we
report
simple
external
ligand-free
Ni-catalyzed
ring-opening
MCPs
with
high
efficiency
unprecedented
regioselective
arylation
as
well
broad
functional
group
tolerance
by
using
inexpensive
aryl
boronic
acids
source.
synthetic
utility
has
been
demonstrated
for
facile
preparation
versatile
highly
valued
products.
Mechanistic
studies
suggest
that
Ni(II)-H,
formed
via
oxidative
addition
Ni(0)
proton
system,
might
act
key
intermediate.
Язык: Английский