Selective C(sp2)–P Cross-Coupling of Alkenylsulfonium Salts with P(O)H Compounds: Divergent Synthesis of Alkenylphosphorus Compounds
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Herein,
we
report
a
both
regioselective
and
stereoselective
method
for
the
formation
of
C(sp2)–P
bonds
using
alkenylsulfonium
salts
>P(O)–H
compounds.
By
employing
palladium
catalyst
or
K2CO3,
variety
(E)-alkenylphosphorus
compounds
terminal
alkenylphosphorus
were
successfully
synthesized
with
high
selectivity.
Notably,
trisubstituted
(Z)-alkenylphosphorus
first
time
under
metal-free
conditions.
This
protocol
has
wide
substrate
scope
good
functional
group
compatibility,
providing
direct
highly
selective
approach
preparation
various
Язык: Английский
Metal‐Free Formation of Xanthenes and Xanthones from 2‐aryloxybenzaldehydes via Intramolecular Cyclization
ChemistrySelect,
Год журнала:
2025,
Номер
10(14)
Опубликована: Апрель 1, 2025
Abstract
We
herein
report
a
metal‐free
strategy
for
the
selective
synthesis
of
xanthenes
and
xanthones
from
2‐aryloxybenzaldehydes.
By
employing
phosphorous
acid/iodine
system,
we
achieved
efficient
preparation
diverse
via
intramolecular
reductive
cyclization.
In
contrast,
series
were
constructed
same
substrates
through
TBAI‐catalyzed
direct
This
methodology
offers
notable
advantages,
including
straightforward
workup,
absence
metal
involvement,
low‐cost.
A
plausible
reaction
mechanism
was
also
proposed.
Язык: Английский