Visible-Light Photoredox-Catalyzed Carboxylation of Benzylic C(sp3)–O Bonds in Ethers with CO2 DOI
Jingwei Yang,

Chuan‐Kun Ran,

Wenjing Zhu

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 5, 2025

Although significant progress has been made in achieving site-selective C-O bond functionalization specific substrates, the selective cleavage and of C(sp3)-O bonds ethers remain a fundamental challenge synthetic chemistry. Herein, we present an efficient carboxylation method via photoredox-catalyzed benzylic with carbon dioxide (CO2). Diverse primary, secondary, tertiary benzyl undergo CO2 to generate valuable aryl acetic acids, including several drug molecules. This photocatalyzed reaction is operationally simple implement versatile for various ethers, exhibiting favorable compatibility diverse functional groups. Mechanistic studies indicate that single electron transfer (SET) reduction might be key generating highly reactive radical anion intermediate, which could another SET process carbanions CO2.

Язык: Английский

CO2 Fixation into Useful Aromatic Carboxylic Acids via C (sp2)–X Bonds Functionalization DOI
Youwen Chen, Mingqiang Chen, Xinyu Li

и другие.

Topics in Current Chemistry, Год журнала: 2025, Номер 383(1)

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

0
Nickel-catalyzed electrochemical carboxylation of propargylic esters with CO2 to 2,3-allenoic acids DOI

Yuqing Zhong,

Mengmeng Jiang,

Deyong Yang

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111169 - 111169

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Rhodium(I)‐Catalyzed C–H Carboxylation of Benzoic Acids and Benzamides with CO2† DOI
Lei Fu,

Raolin Huang,

Shangda Li

и другие.

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Comprehensive Summary The production of chemicals using carbon dioxide (CO 2 ) as the one‐carbon source is a sustainable strategy for organic synthesis. Herein, we report an unprecedented rhodium‐catalyzed, carboxyl‐directed aryl C−H carboxylation benzoic acids with CO under redox‐neutral conditions to afford valuable phthalic acids. In addition, this method could be modified benzamides by different N ‐heterocyclic carbene ligand produce phthalimides, demonstrating versatility protocol.

Язык: Английский

Процитировано

0
Visible-Light Photoredox-Catalyzed Carboxylation of Benzylic C(sp3)–O Bonds in Ethers with CO2 DOI
Jingwei Yang,

Chuan‐Kun Ran,

Wenjing Zhu

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 5, 2025

Although significant progress has been made in achieving site-selective C-O bond functionalization specific substrates, the selective cleavage and of C(sp3)-O bonds ethers remain a fundamental challenge synthetic chemistry. Herein, we present an efficient carboxylation method via photoredox-catalyzed benzylic with carbon dioxide (CO2). Diverse primary, secondary, tertiary benzyl undergo CO2 to generate valuable aryl acetic acids, including several drug molecules. This photocatalyzed reaction is operationally simple implement versatile for various ethers, exhibiting favorable compatibility diverse functional groups. Mechanistic studies indicate that single electron transfer (SET) reduction might be key generating highly reactive radical anion intermediate, which could another SET process carbanions CO2.

Язык: Английский

Процитировано

0