Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 31, 2025

A rapid synthesis of harmicine was achieved through 1,3-dipolar cycloaddition and facile ring reconstruction, including mesylation, cleavage the N-O bond, subsequent cyclization. An enzymatic kinetic resolution developed to obtain optically enriched tetrahydro-β-carboline, which further elaborated prepare harmicine. Additionally, diastereomeric harmicinic acid also achieved, stereochemical determination enabled by chemical electronic circular dichroism calculations for first time, providing an intriguing platform access various derivatives future medicinal research.

Язык: Английский