Characterization and Evaluation Techniques for Core-Shell Nanoconstructs for Cancer Theragnostics
Опубликована: Янв. 1, 2025
Язык: Английский
A review on Advancements in Nanoparticles Based Pulmonary Drug Delivery
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 84 - 94
Опубликована: Июнь 30, 2024
Nanoparticles
have
emerged
as
a
promising
approach
for
pulmonary
drug
delivery,
offering
enhanced
solubility,
targeted
and
improved
therapeutic
efficacy.
This
abstract
reviews
the
recent
advancements
in
field
of
nanoparticle-based
delivery.
It
discusses
various
types
nanoparticles,
including
polymeric,
lipid-based,
inorganic,
their
potential
applications
treatment
respiratory
diseases.
The
review
also
highlights
advantages
nanoparticles
over
conventional
delivery
methods,
such
bioavailability,
reduced
side
effects,
patient
compliance.
Furthermore,
it
examines
challenges
considerations
development
clinical
translation
therapeutics.
concludes
by
outlining
future
research
directions
significance
continued
innovation
this
improving
outcomes.
Язык: Английский
Formulation Development and Comprehensive <i>In Vitro</i> Evaluation of Silymarin-Integrated Isoniazid Tablets for Potential Therapeutic Efficacy in Tuberculosis Treatment
P. C. Jatav,
Ram Shrivastava
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 19 - 25
Опубликована: Дек. 31, 2024
Isoniazid
(INH)
is
a
cornerstone
due
to
its
potent
bactericidal
activity
against
Mycobacterium
tuberculosis.
However,
extended
use
frequently
associated
with
hepatotoxicity,
severe
side
effect
that
can
lead
discontinuation
of
therapy
and
compromise
treatment
outcomes.
INH-induced
hepatotoxicity
primarily
attributed
the
generation
reactive
metabolites
cause
oxidative
stress
hepatocyte
damage.
Silymarin,
derived
from
seeds
Silybum
marianum,
well-known
natural
hepatoprotective
agent.
This
makes
it
promising
candidate
for
mitigating
drug-induced
liver
injuries,
including
those
caused
by
INH.
study
aimed
develop
evaluate
novel
combination
tablet
silymarin
isoniazid,
formulated
using
direct
compression
method.
The
tablets
were
subjected
comprehensive
evaluation
encompassing
physicochemical
properties,
in
vitro
drug
release
studies,
stability
testing,
preclinical
efficacy
assessments.
optimized
formulation,
designated
as
F3,
demonstrated
desirable
mechanical
characteristics,
hardness
5.8
kg/cm²
friability
0.4%.
In
studies
revealed
rapid
achieving
96.5%
within
first
hour,
ensuring
effective
anti-mycobacterial
action.
Concurrently,
was
released
sustained
manner
over
8
hours,
providing
prolonged
effects.
conclusion,
silymarin-isoniazid
offers
dual
advantage
anti-TB
substantial
hepatoprotection.
formulation
represents
significant
advancement
TB
strategies,
potential
enhance
patient
adherence
outcomes
hepatotoxicity.
content
remaining
at
98.96%
no
change
dissolution
behavior.
Язык: Английский
Exploring the Unique Role of Albumin as a Carrier in Nanomedicine-Based Drug Delivery
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 129 - 137
Опубликована: Дек. 31, 2024
Albumin
serves
as
a
compelling
carrier
in
nanomedicine
because
of
its
distinctive
characteristics.
Initially,
it
stands
the
predominant
protein
found
blood,
which
contributes
to
high
compatibility,
biodegradability,
and
safety
for
clinical
applications.
The
structure
facilitates
interaction
with
various
pharmaceuticals,
aiding
their
protection
from
metabolic
degradation
enhancing
efficacy.
Furthermore,
albumin
has
capability
bind
receptors
commonly
present
pathological
tissues,
facilitating
direct
delivery
impacted
regions
without
necessity
additional
targeting
agents.Albumin
possesses
half-life
approximately
19
days
bloodstream,
prolongation
drug
action
enhances
target
sites
precision.
This
article
highlights
significance
systems,
particularly
hydrophobic
drugs,
employing
both
passive
active
mechanisms.
text
examines
advanced
NAB
Technology
advantages
Nab-Paclitaxel
(Abraxane)
relation
conventional
formulations
such
CrEL-paclitaxel
(Taxol).
It
emphasizes
function
transport
anticancer
medications,
concentrating
on
that
are
presently
undergoing
trials.
capabilities
natural
system
importance
efficacy
within
body.
Язык: Английский
Formulation and Evaluation of Solid Dispersion of Nepafenc for Ocular Delivery
S Chouhan,
Ruchi Shrivastava
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 125 - 128
Опубликована: Дек. 31, 2024
Improving
the
bioavailability
of
medications
applied
directly
to
eye
is
still
a
difficulty,
while
topical
administration
typical
way
target
therapies
eye.
Various
approaches
have
been
investigated
tackle
this
problem.
One
these
methods
involves
making
use
aggregates
that
can
be
readily
produced
by
cyclodextrin
(CD)/drug
complexes
in
water-based
solutions.
To
achieve
goal,
we
examined
solid
dispersion's
physicochemical
characteristics
relation
CDs.
Differential
scanning
calorimetry
(DSC)
and
Fourier-transform
infrared
spectroscopy
(FT-IR)
were
utilized
investigate
complex
formation.
According
results,
HPβCD
was
most
effective
at
solubilization.
An
intriguing
approach
improving
nepafenac
could
formulations
comprise
drug/CD
nanoaggregates.
Язык: Английский
A Mini Review on Novel Oral Drug Delivery System for the Effective Treatment of Enteric Fever
Nikhil Rathore,
Sudha Vengurlekar
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 138 - 141
Опубликована: Дек. 31, 2024
Enteric
fever,
primarily
caused
by
Salmonella
typhi
and
paratyphi,
remains
a
significant
global
health
concern,
particularly
in
developing
countries
with
inadequate
sanitation
healthcare
facilities.
The
conventional
treatment
of
enteric
fever
antibiotics,
such
as
fluoroquinolones
third-generation
cephalosporins,
faces
challenges
limited
bioavailability,
side
effects,
bacterial
resistance.
To
overcome
these
issues,
the
development
novel
oral
drug
delivery
systems
(DDS)
that
improve
targeted
release,
overall
therapeutic
efficacy
has
gained
attention.
This
review
aims
to
explore
optimization,
formulation
strategies,
evaluation
techniques
involved
DDS
for
effective
fever.
Язык: Английский
Formulation and Evaluation of Spansules Containing Azithromycin and Meropenem
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 237 - 242
Опубликована: Дек. 31, 2024
This
study
focused
on
developing
and
evaluating
spansules
containing
azithromycin
meropenem
enteric-coated
granules
for
targeted
controlled
drug
delivery.
Azithromycin
were
separately
prepared
using
the
wet
granulation
method
coated
with
Eudragit
L100
HPMC
phthalate
gastric
resistance.
The
optimized
combined
in
predefined
ratios
encapsulated
gelatin
capsules.
Physicochemical
evaluations
revealed
uniform
weight
content
within
pharmacopeial
limits.
Surface
morphology
assessed
via
SEM
confirmed
intact
enteric
coatings.
In
vitro
release
studies
indicated
negligible
fluid
(pH
1.2),
a
significant
simulated
intestinal
6.8).
cumulative
over
12
hours
reached
96.5%
94.8%
meropenem,
demonstrating
effective
release.
Stability
conducted
at
40°C/75%
RH
three
months
showed
no
changes
or
profile,
confirming
formulation
stability.
These
results
suggest
that
developed
provide
promising
approach
improving
therapeutic
efficacy
patient
compliance
of
therapy
by
ensuring
delivery
prolonged
concludes
this
novel
could
address
challenges
treatment
severe
bacterial
infections.
Язык: Английский
Development of Fast Dissolving Films of Ondansetron: Formulation and Evaluation
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 1 - 9
Опубликована: Дек. 31, 2024
Ondansetron,
a
potent
antiemetic
used
to
prevent
nausea
and
vomiting
associated
with
chemotherapy,
radiotherapy,
post-surgical
procedures,
is
typically
administered
in
the
form
of
tablets
or
injections.
However,
these
conventional
dosage
forms
may
pose
challenges,
such
as
difficulty
swallowing,
poor
patient
compliance,
variability
gastrointestinal
absorption.
Fast
dissolving
films
(FDFs)
have
emerged
promising
alternative,
offering
rapid
onset
action,
ease
administration,
enhanced
compliance.
This
study
aimed
formulate,
develop,
evaluate
ondansetron-loaded
FDFs
improve
its
bioavailability
therapeutic
efficacy.
Ondansetron
were
prepared
using
solvent
casting
method,
incorporating
polymers
like
hydroxypropyl
methylcellulose,
Xanthan
gum,
Sodium
starch
glycolate.
The
film
thickness
ranged
from
0.098
0.110
mm,
ensuring
uniformity
across
formulations.
drug
content
was
found
be
consistent,
maximum
99.80%
F7.
dissolution
profile
indicated
that
99%
ondansetron
released
within
5min
simulated
medium.
disintegration
time
varied
8
26
seconds,
action.
folding
endurance
showed
elongation
at
break
110
times
F7,
providing
adequate
flexibility
strength
for
handling.
Stability
studies
40°C/75%
RH
over
three
months
revealed
no
significant
degradation,
remaining
98.96%
change
behavior.
Язык: Английский
Antidiarrhoeal Activity of <i>Plumbago zeylanica</i> using Different Extraction Techniques
Chetana Tripathi,
Sachin Jain,
Sudha Vengurlekar
и другие.
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 196 - 202
Опубликована: Дек. 31, 2024
Diarrheal
diseases
are
a
significant
cause
of
morbidity
and
mortality
worldwide,
especially
in
developing
regions,
underscoring
the
need
for
effective
treatments.
This
study
explores
antidiarrhoeal
potential
Plumbago
zeylanica
through
bioactivity-guided
fractionation
multiple
extraction
techniques.
Methanolic,
aqueous,
hydroalcoholic
extracts
roots
were
evaluated
activity
using
castor
oil-induced
diarrhea
model
Wistar
rats.
Methanolic
extract
at
400
mg/kg
significantly
reduced
by
78%
(p<0.01)
gastrointestinal
transit
65%
(p<0.01).
Aqueous
showed
moderate
effects,
with
reductions
58%
63%
diarrhea,
respectively.
The
findings
validate
traditional
use
treating
highlight
plumbagin
as
promising
lead
molecule
potential.
Язык: Английский
Advanced Applications of Phytosomes in Cancer Therapy: Innovations, Challenges, and Future Perspectives
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 156 - 175
Опубликована: Дек. 31, 2024
Cancer
remains
a
significant
global
health
challenge,
accounting
for
millions
of
deaths
annually
despite
advances
in
diagnosis
and
treatment.
Conventional
cancer
therapies,
including
chemotherapy,
radiotherapy,
immunotherapy,
are
often
limited
by
severe
side
effects,
poor
bioavailability
therapeutic
agents,
non-specific
targeting,
which
can
lead
to
suboptimal
outcomes.
Natural
phytochemicals
derived
from
plants,
such
as
flavonoids,
alkaloids,
terpenoids,
have
shown
immense
potential
prevention
treatment
due
their
antioxidant,
anti-inflammatory,
anticarcinogenic
properties.
However,
clinical
utility
is
hampered
inherent
drawbacks
low
water
solubility,
rapid
metabolism,
bioavailability.
Phytosomes,
an
advanced
drug
delivery
system,
emerged
revolutionary
approach
overcome
these
limitations.
By
forming
complexes
plant
bioactive
compounds
with
phospholipids,
phytosomes
significantly
enhance
the
absorption,
stability,
efficacy
compounds.
This
review
provides
comprehensive
overview
role
therapy,
focusing
on
ability
improve
pharmacokinetic
profiles
enable
targeted
tumor
sites.
The
integration
cutting-edge
technologies
nanotechnology,
personalized
medicine,
combination
therapies
holds
promise
revolutionizing
bridging
gap
between
traditional
phytochemical
therapy
modern
systems,
represent
paradigm
shift
toward
more
effective,
safer,
patient-friendly
treatments.
aims
inspire
further
research
innovation
this
rapidly
evolving
field,
paving
way
next
generation
therapeutics.
Язык: Английский