Electrophysiological Insights into Antibiotic Translocation and Resistance: The Impact of Outer Membrane Proteins
Membranes,
Год журнала:
2024,
Номер
14(7), С. 161 - 161
Опубликована: Июль 20, 2024
The
alarming
rise
of
antibiotic
resistance
in
Gram-negative
bacteria
has
emerged
as
a
major
global
health
challenge.
A
key
factor
contributing
to
this
crisis
is
the
low
permeability
bacterial
outer
membrane,
which
acts
barrier
that
prevents
antibiotics
from
entering
cell.
Protein
channels
embedded
membrane
selectively
regulate
influx
hydrophilic
compounds,
including
antibiotics.
To
combat
resistance,
understanding
molecular
mechanisms
governing
through
crucial.
This
knowledge
towards
elucidating
their
roles
studing
resistance.
By
compiling
and
analysing
flux
data
multiple
electrophysiological
reversal
potential
experimental
studies,
involves
measuring
zero-current
potentials
corresponding
single-channel
conductance,
we
can
calculate
charged
antibiotics/compounds
across
different
channels.
Through
comprehensive
synthesis,
review
aims
advance
our
stimulate
discussions
about
physicochemical
factors
influencing
protein
channels,
ultimately
enhancing
area.
Язык: Английский
Antibacterial carbon dots
Materials Today Bio,
Год журнала:
2024,
Номер
30, С. 101383 - 101383
Опубликована: Дек. 6, 2024
Язык: Английский
Exploring Synergistic Potential of Phytomolecules-Antibiotics Combination Against Escherichia Coli: An Integrated Approach Using Structure Based Drug Design
Pharmacological Research - Natural Products,
Год журнала:
2025,
Номер
unknown, С. 100160 - 100160
Опубликована: Янв. 1, 2025
Язык: Английский
MXene/Carbon Dot Nanocomposites with Photothermal/Physical Synergistic Antibacterial Capability for Wound Healing
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
Язык: Английский
Exploring the Synergistic Effect of Thymol with Oxacillin against Methicillin Resistant Staphylococcus aureus
Indian Journal of Microbiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 23, 2024
Язык: Английский
Ceftobiprole medocaril (Zevtera) – FDA approved antibiotic for three infections including methicillin-resistant Staphylococcus aureus
Journal of Molecular Chemistry.,
Год журнала:
2024,
Номер
4(2)
Опубликована: Апрель 29, 2024
The
U.S.
Food
and
Drug
Administration
(FDA)
has
approved
Zevtera
(ceftobiprole
medocaril
sodium
for
injection)
multiple
therapeutic
indications.
(a
product
of
Basilea
company)
is
now
authorized
use
in
adults
to
treat
Staphylococcus
aureus
bloodstream
infections
(bacteremia),
including
cases
right-sided
infective
endocarditis.
Additionally,
it
with
acute
bacterial
skin
structure
(ABSSSI).
Further,
also
treating
community-acquired
pneumonia
(CABP)
pediatric
patients
aged
three
months
less
than
18
years.
This
broad-spectrum
antibiotic
offers
a
significant
advancement
managing
severe
across
different
age
groups,
enhancing
treatment
options
both
healthcare
providers
patients.
URN:NBN:sciencein.jmc.2024.692
Язык: Английский
An Automated Machine Learning Framework for Antimicrobial Resistance Prediction Through Transcriptomics
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 27, 2024
Abstract
The
emergence
of
antimicrobial
resistance
(AMR)
poses
a
global
threat
growing
concern
to
the
healthcare
system.
To
mitigate
spread
resistant
pathogens,
physicians
must
identify
susceptibility
profile
every
patient’s
infection
in
order
prescribe
appropriate
antibiotic.
Furthermore,
disease
control
centers
need
be
able
accurately
track
patterns
and
pathogens
different
antibiotics.
achieve
this,
high-throughput
methods
are
required
predict
pathogenic
microbe
an
automated
manner.
In
this
work,
transcriptomics-based
approach
utilizing
machine
learning
framework
is
used
goal.
study
highlights
potential
using
gene
expression
as
indicator
Results
indicate
importance
starting
with
high-quality
training
dataset
containing
high
genetic
diversity
sufficient
number
samples.
performed
analysis
reveals
developing
new
feature
reduction
specific
transcriptomic
data.
Most
importantly,
serves
proof-of-concept
impact
deploying
such
models
reduce
mortality
rate
associated
AMR.
Язык: Английский
Phytochemical Composition and Bioactivities of Some Hydrophytes: Antioxidant, Antiparasitic, Antibacterial, and Anticancer Properties and Mechanisms
Plants,
Год журнала:
2024,
Номер
13(15), С. 2148 - 2148
Опубликована: Авг. 2, 2024
Few
researches
have
explored
the
production
of
pharmaceuticals
from
aquatic
plants.
Therefore,
this
study
explored,
for
first
time,
phytochemical
composition
and
bioactivities
ten
Aquatic
plant
shoots
various
Nile
River
canals
were
collected,
dried,
ground
aqueous
extract
preparation.
Phytochemical
antioxidant
capacity
assessed
using
DPPH
assays.
Extracts
tested
antiparasitic,
antibacterial,
anti-biofilm,
anticancer
activities
through
standard
in
vitro
assays,
measuring
IC50
values,
evaluating
mechanisms
action,
including
cell
viability
high-content
screening
The
results
showed
that
plants
rich
pharmaceutical
compounds.
these
extracts
exceeded
vitamin
C.
promising
antiparasitic
activity
against
pathogens
like
Opisthorchis
viverrini
Plasmodium
falciparum,
with
values
between
0.7
2.5
µg/mL.
They
also
demonstrated
low
MICs
pathogenic
bacteria,
causing
DNA
damage,
increased
plasma
membrane
permeability,
90%
biofilm
inhibition.
In
terms
activity,
effective
a
panel
cancer
lines,
Ludwigia
stolonifera
exhibiting
highest
efficacy.
Its
ranged
0.5
µg/mL
pancreatic,
esophageal,
colon
cells
to
1.5
gastric
cells.
Overall,
all
below
6
µg/mL,
showing
significant
apoptotic
nuclear
intensity,
mitochondrial
cytochrome
c
release,
outperforming
doxorubicin.
This
highlights
potential
as
sources
new,
safe,
drugs
strong
properties.
Язык: Английский