PPIH as a poor prognostic factor increases cell proliferation and m6A RNA methylation in hepatocellular carcinoma DOI

Xiaoxia Chi,

Peng Ye,

Nengqi Cao

и другие.

American Journal of Cancer Research, Год журнала: 2024, Номер 14(8), С. 3733 - 3756

Опубликована: Янв. 1, 2024

RNA-binding proteins (RBPs) play a crucial role in the biological processes of liver hepatocellular carcinoma (LIHC). Peptidyl-prolyl cis-trans isomerase H (PPIH), an RBP, possesses prolyl activity and functions as protein chaperone. The relationship between PPIH LIHC has not yet been fully elucidated. This study elucidated potential mechanisms through which affects prognosis LIHC. Bioinformatics analysis vitro experiments revealed that expression was higher tissues than normal tissues. identified independent prognostic factor, with high being associated worse prognoses. Moreover, increased m6A RNA methylation level promoted cell proliferation by modulating DNA replication cycle-related genes cells. also immune infiltration checkpoint proteins. Collectively, these findings indicate might promote progression enhancing level, increasing proliferation, altering tumor microenvironment. Our demonstrates PPIH, poor may lead to malignancy multiple pathways. Further in-depth research on this topic is warranted.

Язык: Английский

PPIH as a poor prognostic factor increases cell proliferation and m6A RNA methylation in hepatocellular carcinoma DOI

Xiaoxia Chi,

Peng Ye,

Nengqi Cao

и другие.

American Journal of Cancer Research, Год журнала: 2024, Номер 14(8), С. 3733 - 3756

Опубликована: Янв. 1, 2024

RNA-binding proteins (RBPs) play a crucial role in the biological processes of liver hepatocellular carcinoma (LIHC). Peptidyl-prolyl cis-trans isomerase H (PPIH), an RBP, possesses prolyl activity and functions as protein chaperone. The relationship between PPIH LIHC has not yet been fully elucidated. This study elucidated potential mechanisms through which affects prognosis LIHC. Bioinformatics analysis vitro experiments revealed that expression was higher tissues than normal tissues. identified independent prognostic factor, with high being associated worse prognoses. Moreover, increased m6A RNA methylation level promoted cell proliferation by modulating DNA replication cycle-related genes cells. also immune infiltration checkpoint proteins. Collectively, these findings indicate might promote progression enhancing level, increasing proliferation, altering tumor microenvironment. Our demonstrates PPIH, poor may lead to malignancy multiple pathways. Further in-depth research on this topic is warranted.

Язык: Английский

Процитировано

0