Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma DOI Creative Commons
Е. Н. Воропаева, Yuriy L. Orlov, A. B. Loginova

и другие.

PeerJ, Год журнала: 2025, Номер 13, С. e18661 - e18661

Опубликована: Янв. 7, 2025

Here, we have discussed the molecular mechanisms of p53-responsive microRNAs dysregulation in response to genotoxic stress diffuse large B-cell lymphoma (DLBCL) patients. The role micro ribonucleic acids (microRNAs) p53-signaling cellular has been studied. MicroRNAs are small non-coding RNAs, which regulate genes expression at post-transcriptional level. Many them play a crucial carcinogenesis and may act as oncogenes or suppressor tumor growth. understanding effect microRNA on oncogenesis achieved recent decades opens wide opportunities for diagnosis, prediction microRNA-based cancer therapy. Development new bioinformatics tools databases supports DLBCL research. We overview studies miRNAs regulating gene associated with tumorigenesis processes, particular emphasis their growth-suppressing factors. starting point is brief description classical biogenesis pathway p53 these molecules. analyze various leading this dysregulation, including mutations TP53 gene, DNA methylation, changes host-genes copy number, genes.

Язык: Английский

Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma DOI Creative Commons
Е. Н. Воропаева, Yuriy L. Orlov, A. B. Loginova

и другие.

PeerJ, Год журнала: 2025, Номер 13, С. e18661 - e18661

Опубликована: Янв. 7, 2025

Here, we have discussed the molecular mechanisms of p53-responsive microRNAs dysregulation in response to genotoxic stress diffuse large B-cell lymphoma (DLBCL) patients. The role micro ribonucleic acids (microRNAs) p53-signaling cellular has been studied. MicroRNAs are small non-coding RNAs, which regulate genes expression at post-transcriptional level. Many them play a crucial carcinogenesis and may act as oncogenes or suppressor tumor growth. understanding effect microRNA on oncogenesis achieved recent decades opens wide opportunities for diagnosis, prediction microRNA-based cancer therapy. Development new bioinformatics tools databases supports DLBCL research. We overview studies miRNAs regulating gene associated with tumorigenesis processes, particular emphasis their growth-suppressing factors. starting point is brief description classical biogenesis pathway p53 these molecules. analyze various leading this dysregulation, including mutations TP53 gene, DNA methylation, changes host-genes copy number, genes.

Язык: Английский

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