Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 11, 2025
Abstract
The
increase
in
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
and
its
progression
to
steatohepatitis
(MASH)
is
a
worldwide
healthcare
challenge.
Heterogeneity
between
men
women
the
prevalence
mechanisms
of
MASLD
MASH
related
differential
sex
hormone
signalling
within
liver,
declining
levels
during
aging.
In
this
study
we
used
biochemically
characterised
pluripotent
stem
cell
derived
3D
spheres
model
protective
effects
testosterone
estrogen
on
‘in
dish’.
We
identified
steroid-dependent
changes
gene
expression
which
were
against
dysfunction,
fibrosis,
advanced
cirrhosis
patterns
expression,
providing
new
insight
into
pathogenesis
MASH,
highlighting
druggable
targets.
Additionally,
highlight
targets
for
drugs
already
exist
future
translational
studies.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 30, 2024
Circular
RNAs
(circRNAs)
have
been
implicated
in
the
development
and
progression
of
gastric
cancer
(GC).
However,
it
remains
unclear
whether
dysregulated
circRNA
affects
immune
escape
efficacy
immunotherapy
GC.
Our
aim
is
to
investigate
molecular
mechanism
affecting
GC
identify
effective
therapeutic
targets.
Cancer Nanotechnology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 17, 2025
Emphasizing
the
significance
of
cancer-associated
fibroblasts
(CAFs),
non-malignant
yet
pivotal
players
within
tumor
microenvironment
(TME),
this
review
illuminates
role
inflammatory
subtype
(iCAF)
as
catalysts
in
cancer
proliferation,
metastasis,
and
therapeutic
resistance.
Given
their
paramount
importance,
targeting
CAFs
emerges
a
robust
strategy
evolving
landscape
immunotherapy.
Nanomaterials,
distinguished
by
unique
features
malleability,
hold
considerable
promise
biomedicine,
especially
precision-oriented
domain
therapy.
Their
aptitude
for
modulating
immune
responses,
amplifying
drug
efficacy
through
precise
delivery,
discerningly
focusing
on
cells
TME
situates
nanomaterials
formidable
tools
to
transcend
boundaries
set
conventional
treatments.
This
scrutinizes
convoluted
interplay
among
CAFs,
cells,
TME.
It
further
showcases
widely
utilized
management.
We
underscore
potential
nanoscale
delivery
systems
directed
at
underscoring
transformative
power
revolutionizing
therapies,
enhancing
precision,
culminating
improved
patient
outcomes.
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 15, 2024
Abstract
Androgenetic
alopecia
(AGA)
is
the
most
prevalent
type
of
hair
loss.
Its
morbility
mainly
psychological
although
an
increased
incidence
in
melanoma
has
also
been
observed
affected
subjects.
Current
drug
based
therapies
and
physical
treatments
are
either
unsuccessful
long
term
or
have
relevant
side
effects
that
limit
their
application.
Therefore,
a
new
therapeutic
approach
needed
to
promote
regenerative
enhancement
alternatives.
These
treatment
options,
focused
on
cellular
niche
restoration,
could
be
solution
impact
dihydrotestosterone
follicle
microenvironment.
In
this
context
emerging
such
as
Platelet-rich
plasma
fibrine
well
stem
cells
mesenchymal
cell
derivatives
(conditioned
medium
CM
exoxomes)
highlighting
evolving
landscape
restoration.
Nanotechnology
leading
way
AGA
through
design
bioinks
nanobiomaterials
whose
structures
being
configuring
huge
range
cases
by
means
3D
bioprinting.
Due
increasing
number
rapid
creation
advanced
alternatives
field,
extended
review
current
state
art
needed.
addition
provides
general
insight
which
intented
guidance
for
researchers
cutting
edge
recently
gaining
ground.
Results in Chemistry,
Год журнала:
2024,
Номер
10, С. 101682 - 101682
Опубликована: Июль 27, 2024
The
multipurpose
properties
of
mixed
metal
oxides
have
garnered
significant
interest.
This
study's
ternary
composite
MnO2/CuO/ZrO2
(MCZ)
exhibited
promising
morphology,
conductivity
and
electrochemical
performance.
MCZ
nanocomposite
was
synthesized
via
hydrothermal
methods.
impact
electrolytes
like
Potassium
hydroxide
(KOH)
on
supercapacitor
features
investigated.
XRD
analysis
determined
the
crystalline
structure,
while
FTIR
confirmed
presence
Cu–O,
O-Mn–O
Zr–O
bonds.
SEM
revealed
uniform
aggregated
particles,
EDAX
elemental
composition.
BET
measured
pore
radius
surface
area.
With
a
1
M
KOH
electrolyte,
performance
evaluated
using
CV,
GCD,
EIS.
electrode
specific
capacitance
869.76
F/g
at
scan
rate
5
mV/s.
symmetric
device
showed
an
energy
density
213.09
Wh/kg
power
3.83
kW/kg,
maintaining
cycling
stability
after
5000
cycles.
displayed
high
ionization
in
solvent,
facilitating
efficient
ion
movement
for
charge
transfer
supercapacitors.
nanocomposite's
areal-specific
119.04
mF/cm2,
with
areal
densities
0.081
mWh/cm2
1.3885
mW/cm2,
respectively.
Increasing
area
materials
enhances
storage
capacity.
study
suggests
that
can
improve
