Health‐Related Quality of Life in Patients With Systemic Autoimmune Rheumatic Diseases (SARD) and Post‐COVID Syndrome: A Case‐Control Study

Musculoskeletal Care, Год журнала: 2025, Номер 23(2)

Опубликована: Май 28, 2025

ABSTRACT Objective To assess the prevalence and characteristics of post‐COVID syndrome its effect on health‐related quality life (HRQOL) COVID‐19‐recovered patients with SARD. Methods This cross‐sectional study included over 18 years old systemic autoimmune rheumatic diseases (SARDs) in addition to sex‐ age‐matched controls without SARDs who tested positive for SARS‐CoV‐2. Sociodemographic variables clinical data related infection severity were collected using EuroQol‐5 dimensions‐5 levels (EQ‐5D‐5L) EuroQol‐visual analogue scales (EQ‐VAS). Results We 58 SARD 116 controls. Post‐COVID was observed 39 (67.2%) 86.2% ( p < 0.001). The most frequent symptoms fatigue (74.4%), anosmia (35.9%), dysgeusia (28.2%). EQ‐VAS score lower than (62.4 ± 18.6 vs. 80.9 7.3; Similarly, had those VAS = 62.4 versus 75.9 14.9; 0.011. Conclusions found that 67.2% affected by COVID‐19 presented persistent symptoms. However, showed significantly HRQL patient

Язык: Английский

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Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease

The Journal of Infectious Diseases, Год журнала: 2024, Номер 230(Supplement_2), С. S150 - S164

Опубликована: Июнь 27, 2024

Abstract Sensory functions of organs the head and neck allow humans to interact with environment establish social bonds. With aging, smell, taste, vision, hearing decline. Evidence suggests that accelerated impairment in sensory abilities can reflect a shift from healthy pathological including development Alzheimer's disease (AD) other neurological disorders. While drivers early alteration AD are not elucidated, insults such as trauma infections affect function. Herein, we review involvement major systems AD, emphasis on microbes exploiting pathways enter brain (the “gateway” hypothesis) potential feedback loop by which function may be impacted central nervous system infection. We emphasize detection changes first-line surveillance senior adults identify remove insults, like microbial infections, could precipitate pathology.

Язык: Английский

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Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 12, 2023

ABSTRACT Why individuals with Down Syndrome (DS, trisomy 21) are particularly susceptible to SARS CoV-2 induced neuropathology remains largely unclear. Since the choroid plexus (CP) performs important barrier and immune-interface functions, secretes cerebrospinal fluid strongly expresses ACE2 receptor chromosome 21 encoded TMPRSS2 protease, we hypothesized that CP could play a role in establishing SARS-CoV-2 infection brain. To investigate of central nervous system DS, established new type brain organoid from DS isogenic euploid control iPSC consists core appropriately patterned functional cortical neuronal cell types is surrounded by patent (CPCOs). Remarkably, DS-CPCOs not only recapitulated abnormal features development but also revealed defects ciliogenesis epithelial polarity developing plexus. We next demonstrate layer facilitates replication cells, this increased DS-CPCOs. further show inhibition Furin activity inhibits CPCOs level observed organoids. conclude useful model for dissecting forebrain enables screening therapeutics can inhibit neuro-pathogenesis.

Язык: Английский

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Does COVID-19 Trigger the Risk for the Development of Parkinson’s Disease? Therapeutic Potential of Vitamin C

Molecular Neurobiology, Год журнала: 2023, Номер 61(12), С. 9945 - 9960

Опубликована: Ноя. 14, 2023

Язык: Английский

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Identification of Natural Compounds for Long COVID Based on Hub Gene Biomarkers and Repurposed Drugs

Опубликована: Авг. 13, 2024

Long COVID is a phenomenon in which individuals experience persistent symptoms after recovering from COVID-19. The are discovered to be unique for every individual and can affect multiple organs systems the body. This study aims identify effective natural remedies long by analyzing hub genes associated with of condition evaluating repurposed drugs catered used treating COVID. most common prevalent were identified; Fatigue, Shortness Breath, Loss Smell, Headache, Brain Fog, Chest Pain, Insomnia, Heart Palpitations, Dizziness, Joint Depression, Anxiety, Tinnitus, Appetite. Hub each provided an insight on key biological pathways symptom. Repurposed identified, template compounds similar structure as potential therapeutic drug. retrieved using fingerprint search NPASS Database. findings this suggest several symptom based molecular docking gene compound iGEMDOCK. identified may hold promise COVID, but further research required explore efficacy effectiveness proposed compounds. results pose important implications development treatments

Язык: Английский

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Understanding Post-COVID-19: Mechanisms, Neurological Complications, Current Treatments, and Emerging Therapies

International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 6303 - 6321

Опубликована: Дек. 1, 2024

COVID-19, a highly infectious disease, caused worldwide pandemic in early 2020. According to the World Health Organization (WHO), COVID-19 has resulted approximately 774 million cases and around 7 deaths. The effects of are well known; however, there is lack information on pathophysiological mechanisms underlying symptoms that comprise Post-Acute Syndrome (PACS) or Long COVID-19. Neurological sequelae common, with cognitive dysfunction being one foremost symptoms. Research indicates elevated inflammatory levels increased oxidative stress may play role etiology severity PACS. Treatment options extremely limited, no consensus among medical scientific communities how manage disease. Nevertheless, many scientists advocate for using antioxidants symptomatic therapy behavior supportive care. Additionally, current research aims ameliorate several aspects cascade. This review highlights intracellular extracellular pathways crucial neurological manifestations PACS, providing valuable healthcare professionals scientists. Given complex nature understanding these essential developing new treatment options. Assessing PACS challenging, reviewing therapeutic while proposing triad potential elements will add value clinical assays guidelines. Current strategies, such as antioxidants/vitamin supplements, neurogenic stem cell therapy, mitochondrial could be combined enhance their effectiveness. Future should focus validating approaches exploring avenues effective

Язык: Английский

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Factors Associated with Long COVID-19 in a French Multicentric Prospective Cohort Study

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(17), С. 6678 - 6678

Опубликована: Авг. 29, 2023

(1) Background: A substantial proportion of COVID-19 patients continue to experience long-lasting effects that hamper their quality life. The objectives this study were report the prevalence persistent clinical symptoms 6–12 months after onset and (2) identify potential factors at admission associated with occurrence long COVID. Methods: prospective was conducted among adult patients, hospitalized in four French university hospitals. Patients invited two ambulatory follow-up medical visits, 6–8 (visit #1) one year #2) COVID-19. multivariate logistic regression performed assess (3) Results: In total, 189 participated (mean age 63.4 years). BMI > 30 kg/m2 (aOR 3.52), AST levels between 31 42 U/L 8.68), 3.69) visit #1. Anosmia 13.34), 10.27), stay ICU 5.43), pain 4.31), longer time before hospitalization 1.14) significantly #2. ageusia 0.17) had a lower risk (4) Conclusions: This showed some experienced determinants acute phase/stage.

Язык: Английский

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SARS-CoV-2 neurotropism and other possible causes of olfactory disorders in COVID-19

Neurologia i Neurochirurgia Polska, Год журнала: 2023, Номер 57(1), С. 36 - 42

Опубликована: Фев. 20, 2023

Язык: Английский

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Viral Shedding and Persistence of Anosmia and Ageusia in an Asymptomatic SARS-CoV-2 Infection

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Март 23, 2023

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in the region of Wuhan, China is responsible for ongoing pandemic disease-19 (COVID-19) that has been a part our life almost three years now. Although there have multiple reports prolonged viral shedding people with disease, lasting extended periods can occur patients less serious clinical insults or even asymptomatic individuals. Herein, we report case female patient that, although otherwise asymptomatic, remained positive on nasopharyngeal testing period, alongside persisting complaints anosmia and ageusia. may well one individuals to be infected Greek territory; followed up her long-term COVID sequelae from time proof infection until present day.

Язык: Английский

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Is Olfactory Testing a Useful Diagnostic Tool to Identify SARS-CoV-2 Infections Early? A Cross-Sectional and Longitudinal Analysis

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(9), С. 3162 - 3162

Опубликована: Апрель 27, 2023

Genesis and the prognostic value of olfactory dysfunction (OD) in COVID-19 remain partially described. The objective our study was to characterize OD during SARS-CoV-2 infection examine whether testing may be a useful tool clinical practice order early identify patients with infection.Olfactory function assessment objectively carried out using u-Smell-it® test. In cross-sectional part, we evaluated this test control cohort negative tested patients, who attended University Hospital Frankfurt between May 2021 March 2022. second longitudinal sensitivity specificity as diagnostic marker am Main, Germany infected their close contacts.Among 494 detected 45.7% found significantly associated male gender (p < 0.001), higher age cardiovascular pulmonary comorbidities 0.001; p = 0.03). Among 90 positive 65.6% smoking status 0.04 each). Prevalence severity were increased infections Delta variant (B.1.617.2) compared those Omicron (BA.1.1.529). Diagnostic for diagnosis 69% 64%, respectively.OD is common different prevalence rates observed variants. accuracy not high enough implement routine infection.

Язык: Английский

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