The role of Akkermansia muciniphila in colorectal cancer: A double-edged sword of treatment or disease progression?

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 173, С. 116416 - 116416

Опубликована: Март 11, 2024

Colorectal cancer (CRC) is the second most cancer-related death worldwide. In recent years, probiotics have been used to reduce potential risks of CRC and tumors with various mechanisms. Different bacteria suggested play different roles in progression, prevention, or treatment CRC. Akkermansia muciniphila considered a next-generation probiotic for preventing treating some diseases. Therefore, this review article, we aimed describe discuss mechanisms A. as an intestinal microbiota Some studies that abundance was higher increased patients compared healthy individuals. However, decreased associated severe symptoms CRC, indicating did not role development addition, administration elevates gene expression proliferation-associated molecules such S100A9, Dbf4, Snrpd1, markers cell proliferation. other inflammation tumorigenesis intestine might promoted by muciniphila. Overall, inhibition still unclear controversial. Various methods bacterial supplementation, viability, number, abundance, could all influence colonization effect progression. mucinipila has revealed modulate therapeutic immune checkpoint inhibitors. Preliminary human data propose oral consumption safe, but its efficacy needs be confirmed more clinical studies.

Язык: Английский

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Insights into the Mechanisms of Action of Akkermansia muciniphila in the Treatment of Non-Communicable Diseases

Nutrients, Год журнала: 2024, Номер 16(11), С. 1695 - 1695

Опубликована: Май 29, 2024

This comprehensive review delineates the extensive roles of Akkermansia muciniphila in various health domains, spanning from metabolic and inflammatory diseases to neurodegenerative disorders. A. muciniphila, known for its ability reside mucous layer intestine, plays a pivotal role maintaining gut integrity interacting with host processes. Its influence extends modulating immune responses potentially easing symptoms across several non-communicable diseases, including obesity, diabetes, bowel disease, cancer. Recent studies highlight capacity interact gut–brain axis, suggesting possible impact on neuropsychiatric conditions. Despite promising therapeutic potential highlighted animal preliminary human studies, challenges remain practical application due stability cultivation issues. However, development pasteurized forms synthetic mediums offers new avenues use clinical settings, as recognized by regulatory bodies like European Food Safety Authority. narrative serves crucial resource understanding broad implications different conditions integration into strategies.

Язык: Английский

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Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 14, 2025

Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and considered one common primary malignant neoplasms. The prognosis for HCC dismal because its complicated etiology high level medication resistance. Immunotherapy presently regarded as effective therapeutic options HCC; nevertheless, disturbance intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body research indicates that particularly Akkermansia muciniphila ( A. ), vital treatment tumors. Studies have demonstrated diminished effectiveness in cancer patients associated with a reduction levels, suggesting levels significantly enhance efficacy immunotherapy. functions gut probiotic can treat prevent wide range illnesses, including cancer. Consequently, preserving abundance enough to lower danger developing disorders. In this review, we critically evaluate current on , focus biological properties functions. different illnesses treats were then discussed, way it works This review aims give novel plan well theoretical foundation improving

Язык: Английский

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Akkermansia muciniphila-derived pentadecanoic acid enhances oxaliplatin sensitivity in gastric cancer by modulating glycolysis

Pharmacological Research, Год журнала: 2024, Номер 206, С. 107278 - 107278

Опубликована: Июнь 20, 2024

Accumulating evidence has proved the close association between alterations in gut microbiota and resistance to chemotherapeutic drugs. However, potential roles of regulating oxaliplatin sensitivity gastric cancer (GC) have not been investigated before. We first found that antibiotic treatment diminished therapeutic efficacy a GC mouse model. Importantly, this effect could be transmitted germ-free mice via fecal transplantation, indicating role modulation efficacy. Further, metagenomics data showed Akkermansia muciniphila (A. muciniphila) ranked among bacterial species with decreased relative abundances after treatment. Metabolically active A. promotes As shown by metabolomics analysis, metabolic pattern was disrupted significantly downregulated levels pentadecanoic acid (PEA), use PEA promoted Mechanistically, FUBP1 positively regulated aerobic glycolysis cells hinder oxaliplatin. muciniphila-derived functioned as an inhibitory factor directly antagonizing activity FUBP1, which potentiated responses Our research suggested key for intestinal its metabolite promoting efficacy, thus providing new perspective probiotic prebiotic intervention patients during chemotherapy.

Язык: Английский

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Modulation of multiple sclerosis risk and pathogenesis by the gut microbiota: Complex interactions between host genetics, bacterial metabolism, and diet

Immunological Reviews, Год журнала: 2024, Номер 325(1), С. 131 - 151

Опубликована: Май 8, 2024

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, affecting nearly 2 million people worldwide. The etiology MS multifactorial: Approximately 30% risk genetic, which implies that remaining ~70% environmental, with a number factors proposed. One recently implicated factor for composition gut microbiome. Numerous case-control studies have identified changes in microbiota (pwMS) compared healthy control individuals, and more recent animal models begun to identify causative microbes underlying mechanisms. Here, we review some these mechanisms, specific focus on role host genetic variation, dietary inputs, microbial metabolism, particular emphasis short-chain fatty acid tryptophan metabolism. We put forward model where, individual genetically susceptible MS, diet can synergize as potent environmental modifiers possibly progression, diet-dependent metabolites serving key mechanism. also propose taxa may divergent effects individuals carrying distinct variants alleles or other polymorphisms, consequence gene-by-gut interactions. Finally, taxa, especially those exert their through metabolites, are highly dependent intake. What emerges complex multifaceted interaction has been challenging disentangle human studies, contributing divergence findings across heterogeneous cohorts differing geography, preferences, genetics. Nonetheless, this provides individualized, yet tractable, how regulate susceptibility potentially progression disease. Thus, conclude prophylactic therapeutic modulation microbiome prevent treat will require careful personalized consideration genetics, baseline composition, inputs.

Язык: Английский

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Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay

Journal of Molecular and Cellular Cardiology, Год журнала: 2024, Номер 194, С. 16 - 31

Опубликована: Май 29, 2024

Язык: Английский

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Traditional Medicine Xianglian Pill Suppresses high-fat diet-related colorectal cancer via inactivating TLR4/MyD88 by remodeling gut microbiota composition and bile acid metabolism

Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118411 - 118411

Опубликована: Май 31, 2024

Язык: Английский

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The interaction between Angelica sinensis polysaccharide ASP-2pb and specific gut bacteria alleviates rheumatoid arthritis in rats

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140473 - 140473

Опубликована: Янв. 1, 2025

Язык: Английский

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Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis

Cancer Medicine, Год журнала: 2025, Номер 14(6)

Опубликована: Март 1, 2025

ABSTRACT Background Chronic gut inflammation and dysbiosis contribute significantly to colorectal cancer (CRC) development. Shaoyao decoction (SYD) is a well‐established Chinese medicine prescription. Besides ameliorating CRC via anti‐inflammatory effects, SYD modulates microbiota (GM) improve inflammatory responses in ulcerative colitis (UC). However, whether how suppresses by regulating GM remains largely unknown. Methods SD rats were orally administered for 7 days obtain medicated serum. We utilized liquid chromatography–mass spectrometry (LC–MS) analysis, GeneCards, DisGeNET, SwissTargetPrediction databases analyze blank SYD‐medicated rat serum, comparing the findings with those of aqueous extract previous studies identify circulating compounds/components predictable target genes. Using network pharmacology, potential active compounds corresponding hub genes associated modulating suppress selected molecular docking. In vivo experiments, transplantation tumor model was established BALB/c mice using CT26 cells, gavage 14 days. To investigate mechanism SYD‐regulated against CRC, HE IHC staining, Western blotting, 16S rRNA sequencing employed. Results LC–MS identified 26 computationally predicted Network pharmacology prioritized 13 targeting 8 inflammation/immunity‐related (IL‐17/TNF pathways), validated dose‐dependently suppressed growth ( p < 0.05, medium/high doses), as confirmed staining analysis Ki‐67. Notably, potentially delayed liver metastasis alleviated hepatic injury tumor‐bearing mice. blotting demonstrated SYD's inhibition IL‐17/TNF/NF‐κB axis, aligning computational predictions. revealed SYD‐enriched Akkermansia structural shifts, mechanistically linking remodeling anti‐tumor efficacy. Conclusions combats dual modulation signaling ecosystems (e.g., enrichment). This microbiota‐immune crosstalk positions adjunct conventional therapies, particularly patients dysbiosis.

Язык: Английский

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Parabacteroides johnsonii Inhibits the Onset and Progression of Colorectal Cancer by Modulating the Gut Microbiota

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Background Colorectal cancer (CRC) is the third most prevalent malignant tumor and second leading cause of cancer-related deaths globally. The genus Parabacteroides an important component gut microbiota. P. distasonis goldsteinii are reported probiotics, their roles in CRC have been investigated related studies. However, association between johnsonii remains unknown. Methods (10–42) Lactococcus formosensis (22–2) were isolated from healthy human feces. 25 mice that demonstrated normal feeding activity randomly assigned to four groups : control (NC group), model (IC (PJ L. (LO group). Colonic tissues IC, PJ, LO colon NC group then collected for HE staining immunohistochemical staining. Fecal samples during hyperproliferative adenoma phases Metagenomic sequencing metabolite analysis. Results intervention reduced number slowed growth colonic tumors, improved histological scores, decreased microenvironmental inflammation levels. composition intestinal flora with cancer, increased microbial species diversity, maintained microbiota stability. Furthermore, abundance Bifidobacterium pseudolongum Lactobacillus, which play a role ameliorating AOM/DSS-induced dysbiosis. affected metabolic pathways, including amino sugar degradation galactose metabolism, sphingolipid synthesis, acid polyphenol synthesis tryptophan metabolism pathway as primary being affected. Conclusion Our study profiled administration reduces tumors lower staging by modulating its metabolites at early stages.

Язык: Английский

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