‘Hair Color Repigmentation in the Recipient Area‘: A Newly Recognized Phenomenon after Hair Transplantation DOI
Muhammad K. Al-Bakaa,

Basu Mullick C,

Sánchez Cano M

и другие.

Cardiometry, Год журнала: 2024, Номер 31, С. 89 - 98

Опубликована: Май 25, 2024

Background: Hair color repigmentation in the recipient area is a newly detected phenomena after hair transplantation. It’s especially patients with gray or white hairs donor area, which transferring these follicles to stimulate them regain their original blackish color, this may occur due various stimulants that release during wound healing of slits transplantation trigger melanin production within melanocyte inside roots and promote area. Aim: The aim study was detect frequency Patients Methods: In retrospective observational study, we thirty-four develop restoration undergoing throughout 1-year follow-up period. 1438 undergo transplant between August 2021 May 2023 were enrolled among 34 vulnerable phenomena, each patient assessed both objectively subjectively evaluate occurrence phenomenon percentage restore transplanted Results: Thirty-four completed evaluation score includes (percentage show transplantation, change degree area) patient’s satisfaction showed greater positive results majority Conclusion: surgery. Most We think detecting will give us insight about how can our by understanding mechanism melanocytes root ability

Язык: Английский

Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser DOI Creative Commons
Suparuj Lueangarun, Byong Seung Cho, Therdpong Tempark

и другие.

Journal of Cosmetic Dermatology, Год журнала: 2024, Номер 23(6), С. 2307 - 2311

Опубликована: Фев. 28, 2024

Exosomes, extracellular vesicles, have been shown to play a central role in hair morphogenesis and regeneration,1 with the potential for use treatment of alopecia other trichologic conditions.2 The preclinical3 clinical evidence support their effectiveness combination microneedle therapy.4 Moreover, exosomes demonstrated crucial regulating pigmentation, especially interplay between keratinocytes melanocytes within epidermal melanin unit.5 Positioned prominently this unit, secrete containing soluble factors microRNAs (miRNAs), influencing pigmentation modulation skin homeostasis.6 However, repigmentation, conditions such as poliosis, remains understudied. Therefore, research investigates case 38-year-old male androgenetic (AGA) poliosis circumscripta—a localized patch white hair. study explores efficacy fractional picosecond laser (FPL) treatment, focusing on addressing both AGA promoting repigmentation patches. A man no significant past medical history presented 10 years underlying diseases was not currently taking any medication. Additionally, he observed 12 right parietal scalp area, which remained same shape throughout period. dermatologic examination revealed lock (poliosis circumscripta) arising from pigmented cutaneous lesion (Figure 1). patient treated including area addressed using novel technique published by Lueangarun Tempark7 Nd:YAG 1064-nm lens array spot size 8 mm (DiscoveryPICO®; QuantaSystem, S.p.A., Samarate, VA, Italy). fluence set at 0.06–0.1 J/cm2 (resulting minimal reaction, shaft breakage, an acceptable pain score), frequency Hz 3–4 passes. optimal endpoint very mild erythema pinpoint bleeding. Subsequently, 5 mL (ASCE + HRLV-S; ExoCoBio Inc., Seoul, Korea), 20 mg lyophilized Rose Stem Cell Exosomes (RSCEs) billion exosome particles, applied entire thinning every 4 weeks four sessions without additional treatment. trichoscopic had evaluated frontal mid-scalp nevus point reference also patch. At last showed improvement regrowth. Interestingly, gray circumscripta, hair, after treatments 1, Appendix S1) We dermoscopic evaluation. For evaluation, we employed method described Bae et al.,8 showing proximal black coloring observed, whereas distal part 2). This report demonstrates loss interestingly, it showcases patches (poliosis) (Appendix S2) following FPL To best our knowledge, previous studies linked depigmentation poliosis.9 Poliosis, characterized can arise various inherited defects, autoimmune damage, or follicular harm.10 Repigmentation, often seen like areata (AA) vitiligo, is facilitated anti-inflammatory effects changes melanocyte stem cells.8, 11 Treatments associated inflammation aim reduce responses, interleukin-1-beta related peptides playing roles.11 Radiation therapy UV light induce while drugs Dupilumab stimulate regrowth disrupting melanogenesis.12 Melanocyte cell activation may contribute supported successful cases involving epithelial grafting unit extraction.8 Hair transplantation has proven effective correcting pubic vitiligo.13 These approaches involve stimulating migration supply bulbs mature melanocytes, highlighting mechanisms cases.13, 14 In case, (FPL)7 treat disorder non-thermal technology laser-induced optical breakdown (LIOB) promote growth creating petechiae, aiding wound healing, releasing factors, enhancing Wnt/β-catenin signaling.15 study, isolated Exosome-like Particles culture supernatant advanced techniques. RSCEs, ranging 90 200 nm, were rich microRNAs. They noteworthy dermal fibroblast growth, reducing acting agents. findings highlight RSCEs regeneration, disorders, treatment.16 identified literature reviews having diverse impact overall health. First, they exhibit effect,17 inflammation, particularly (AA). Mesenchymal cell-derived adipose tissue notably decrease pro-inflammatory cytokines increasing ones inflammatory disease models.16, 18 Second, these show antioxidative stress properties, are beneficial helping regulate body's defense system19 mitigate oxidative stress-induced damage.20 Third, processes. influence melanogenesis affecting signaling pathways, proliferation, tyrosinase activity, enzyme vital production.19, 21 suggests that could modulate precursors follicle.22 Last, cycle. carry Wnt proteins, activate β-catenin pathway, essential regeneration.23, 24 contain specific miRNAs (such miR-8485, miR-574-5p, miR-1246) proliferation but cancer cells.25-28 medications, monoclonal antibodies (e.g., anti-PD-1/PD-L1, Dupilumab, Adalimumab), tyrosine kinase inhibitors imatinib, nilotinib), immunomodulatory lenalidomide, thalidomide). Other cyclosporine A, high-dose thyroxine, latanoprost effect. exact fully understood immune-modulating pathways.29, 30 micro-injury techniques, Mohs surgery,31 activating Cells follicles.32 process driven Wnt/β-Catenin vitiligo,33 EDN3/EDNRB signaling,34 procedures epilation. suggest pathways microinjuries, offering options. Hence, be conclusively attributed solely exosomes, due concurrent FPL. study's limitations include its basis single new topical product therapy, limiting generalizability results. promising, require cautious interpretation small sample effects. More extensive, controlled needed definitive conclusions. Further suggested understand treatment's safety, broader application, treating pigmentary conditions. highlights circumscripta through treatments. effectively patches, approach. proposes several effects, regulation, promotion Despite promising results, acknowledges need further hypopigmentary advance future authors conflict interest. All performed human participants accordance ethical standards 1964 Helsinki Declaration later amendments comparable standards. signed informed consent form understanding nature trial. data available corresponding author upon reasonable request. S1 S2 Please note: publisher responsible content functionality supporting information supplied authors. Any queries (other than missing content) should directed article.

Язык: Английский

Процитировано

11
Thiol-Enhanced Interfacial and Internal Deposition of Metal–Polyphenol Networks for Permanent Hair Dyeing DOI

Chengge Fang,

Ling Ma,

Timson Chen

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Metal polyphenolic networks (MPNs) are becoming more and attractive for nontoxic hair dyeing, but their coloring effect is not satisfactory because of the limited interfacial deposition absence internal deposition. Moreover, there a lack understanding driving factors MPNs on hair. Herein, we develop simple yet efficient strategy that transforms disulfide bonds into thiol groups by thioglycolic acid (TGA) to highly enhance at low temperature. The reactive react with Fe2+ form Fe-S bonds, greatly facilitating thus resulting in rapid coloration high darkness. TGA-assisted MPNs-dyed (TGA/MPN) shows resistance washing shampoo. Further, it found connection endows TGA/MPN similar mechanical structural properties natural white even enables simultaneous dyeing perming. This study offers novel universal permeation MPNs.

Язык: Английский

Процитировано

0
Decoding driver and phenotypic genes in cancer: Unveiling the essence behind the phenomenon DOI Creative Commons
Dequan Liu, Lei Liu, Xiaoman Zhang

и другие.

Molecular Aspects of Medicine, Год журнала: 2025, Номер 103, С. 101358 - 101358

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

0
Achieving Sustained Hair Repigmentation in Poliosis Circumscripta: Retreatment Outcomes Using Exosomes and Fractional Picosecond Laser DOI Creative Commons
Suparuj Lueangarun, Byong Seung Cho, Therdpong Tempark

и другие.

Journal of Cosmetic Dermatology, Год журнала: 2025, Номер 24(3)

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Acitretin-Induced Repigmentation of Gray Hair: A Case Report DOI Open Access
Eunice Y. Chow, Thomas G. Salopek

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Апрель 14, 2024

Acitretin is an oral retinoid with alopecia as a possible adverse effect. However, repigmentation of the hair color after acitretin not well-documented phenomenon. Herein, we introduce case where patient's darkened course acitretin.

Язык: Английский

Процитировано

1
Intrinsic and Extrinsic Factors Associated with Hair Graying (Canities) and Therapeutic Potential of Plant Extracts and Phytochemicals DOI Creative Commons
Yong Chool Boo

Applied Sciences, Год журнала: 2024, Номер 14(17), С. 7450 - 7450

Опубликована: Авг. 23, 2024

This review aims to gain insight into the major causes of hair graying (canities) and how plant-derived extracts phytochemicals could alleviate this symptom. Research articles on human were searched selected using PubMed, Web Science, Google Scholar databases. We first examined intrinsic extrinsic factors associated with graying, such as reduced capacity melanin synthesis transfer, exhaustion melanocyte stem cells (MSCs) melanocytes, genetics epigenetics, race, gender, family history, aging, oxidative stress, stress hormones, systematic disorders, nutrition, smoking, alcohol consumption, lifestyle, medications, environmental factors. also various plants that have shown a potential interfere onset or progression at different levels from in vitro studies clinical studies: extract Polygonum multiflorum its components, 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside emodin; Eriodictyon angustifolium flavonoid compounds, hydroxygenkwanin, sterubin, luteolin; Adzuki beans (Vigna angularis), Fuzhuan brick tea (Camellia sinensis), Gynostemma pentaphyllum; bixin, carotenoid compound found Bixa orellana; rhynchophylline, an alkaloid certain Uncaria species. Experimental evidence supports notion plant by enhancing MSC maintenance function, reducing due physiological influences, managing secretion action hormones appropriate level. It is suggested may be reversible through following tactical approaches: selective targeting p38 mitogen-activated protein kinase (MAPK)–microphthalmia-associated transcription factor (MITF) axis, nuclear erythroid 2-related 2 (NRF2), norepinephrine–β2 adrenergic receptor (β2AR)–protein A (PKA) signaling pathway.

Язык: Английский

Процитировано

1
Premature hair graying: a multifaceted phenomenon DOI Creative Commons
Deesha Desai, Maria Karim,

Ambika Nohria

и другие.

International Journal of Dermatology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

Premature hair graying (PHG) is the early loss of natural color, influenced by genetic, biological, and environmental factors. This review discusses significant psychological impacts PHG explores its underlying mechanisms, related health conditions, available treatments. The examines roles genetics, oxidative stress, lifestyle factors such as smoking diet in premature graying. It also considers associated medical conditions current emerging treatment options. overview aims to improve understanding broader implications.

Язык: Английский

Процитировано

0
‘Hair Color Repigmentation in the Recipient Area‘: A Newly Recognized Phenomenon after Hair Transplantation DOI
Muhammad K. Al-Bakaa,

Basu Mullick C,

Sánchez Cano M

и другие.

Cardiometry, Год журнала: 2024, Номер 31, С. 89 - 98

Опубликована: Май 25, 2024

Background: Hair color repigmentation in the recipient area is a newly detected phenomena after hair transplantation. It’s especially patients with gray or white hairs donor area, which transferring these follicles to stimulate them regain their original blackish color, this may occur due various stimulants that release during wound healing of slits transplantation trigger melanin production within melanocyte inside roots and promote area. Aim: The aim study was detect frequency Patients Methods: In retrospective observational study, we thirty-four develop restoration undergoing throughout 1-year follow-up period. 1438 undergo transplant between August 2021 May 2023 were enrolled among 34 vulnerable phenomena, each patient assessed both objectively subjectively evaluate occurrence phenomenon percentage restore transplanted Results: Thirty-four completed evaluation score includes (percentage show transplantation, change degree area) patient’s satisfaction showed greater positive results majority Conclusion: surgery. Most We think detecting will give us insight about how can our by understanding mechanism melanocytes root ability

Язык: Английский

Процитировано

0