Ingested Polystyrene Micro-Nanoplastics Increase the Absorption of Co-Ingested Arsenic and Boscalid in an In Vitro Triculture Small Intestinal Epithelium Model
Microplastics,
Год журнала:
2025,
Номер
4(1), С. 4 - 4
Опубликована: Янв. 7, 2025
Micro-nano
plastics
(MNPs)
are
emerging
environmental
and
food
contaminants
that
raising
serious
health
concerns.
Due
to
the
polycontamination
of
web
with
pollutants
(EPs),
now
MNPs,
co-ingestion
EPs
MNPs
is
likely
occur,
potential
synergistic
effects
such
co-ingestions
completely
unstudied.
In
this
study,
we
therefore
sought
determine
two
model
EPs,
arsenic
boscalid,
on
uptake
toxicity
25
1000
nm
polystyrene
(PS-25
PS-1000),
vice
versa,
employing
a
triculture
small
intestinal
epithelium
combined
simulated
digestion.
24
h
exposures,
neither
nor
+
caused
significant
toxicity.
The
presence
PS-25
significantly
increased
(from
0.0
5.8%,
p
<
0.001)
translocation
5.2
9.8%,
0.05)
but
had
no
effect
boscalid
or
translocation,
whereas
PS-1000
either
EP.
both
PS
was
also
by
rising
from
10.6
19.5%
(p
0.01)
for
4.8
8.5%
PS-1000.
These
findings
highlight
need
further
studies
assess
MNP-EP
interactions
possible
adverse
impacts.
Язык: Английский
Micro-nanoplastics pollution and mammalian fertility: a systematic review and meta-analysis
Theriogenology,
Год журнала:
2025,
Номер
238, С. 117369 - 117369
Опубликована: Фев. 26, 2025
Язык: Английский
Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics
Frontiers in Toxicology,
Год журнала:
2025,
Номер
7
Опубликована: Апрель 15, 2025
Micro-
and
nanoplastics
(MNPs)
are
widespread
environmental
pollutants
that
pose
significant
health
risks.
They
originate
from
industrial
processes,
consumer
products,
degradation,
inducing
oxidative
stress
through
cellular
dysfunctions
such
as
membrane
interaction,
internalization,
mitochondrial
damage,
inflammation,
metal
ion
leaching,
impaired
antioxidant
defense.
Despite
increasing
evidence
of
their
toxicity—particularly
developmental
neurotoxicity
(DNT)
impairment—our
understanding
remains
limited
due
to
the
high
costs
animal
studies,
which
reduce
overall
size
experimental
data.
This
underscores
urgent
need
for
alternative
test
methods
cost-effective,
rapid,
translational.
review
examines
new
approach
methodologies
(NAMs)
DNT
assessment,
addressing
ethical,
financial,
translational
limitations
models.
NAMs
integrate
three
complementary
non-animal
models
enhance
conventional
testing.
First,
zebrafish
provide
organismal
insights
into
behavioral
neurodevelopmental
outcomes
at
minimal
cost.
Second,
neuronal
organoids
replicate
human-specific
processes
in
a
3D
system,
offering
mechanistic
insights.
Lastly,
human
cell
lines
enable
high-throughput
screening,
integrating
findings
organoid
studies.
Establishing
paradigm
testing
is
crucial
faster
more
efficient
toxicity
risk
assessments,
ultimately
protecting
public
health.
Standardizing
gaining
regulatory
acceptance
will
improve
predictive
accuracy
broaden
application
toxicology.
Advancing
these
essential
risks
MNP
exposure
while
promoting
ethical
sustainable
research
practices.
Язык: Английский
Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks
Biophysica,
Год журнала:
2024,
Номер
4(4), С. 724 - 746
Опубликована: Дек. 21, 2024
Microplastics
(MPs)
are
widespread
environmental
pollutants
that
have
drawn
significant
attention
due
to
their
possible
health
risks
humans
and
animals,
as
well
extensive
presence
in
ecosystems.
Recent
growing
evidence
highlights
a
remarkable
relationship
between
MPs
extracellular
vesicles
(EVs),
nanoscale
particles
involved
intercellular
communication.
The
purpose
of
this
review
was
investigate
how
the
relationships
EVs
can
affect
cellular
functions
interaction
could
impact
conditions
leading
broader
ecological
risks.
patterns
bioactivity
both
strongly
influenced
by
biophysical
characteristics
such
hydrophobicity,
surface
charge,
particle
size,
which
received
particular
from
scientific
community.
studies
indicate
EV
distribution
capacity
function
appropriately
biological
systems.
Additionally,
modify
molecular
cargo
EVs,
may
result
alterations
cell
signaling
pathways.
Understanding
interactions
provide
important
opportunities
comprehend
potential
effects
on
human
systems,
especially
when
it
comes
cancer
development,
endocrine,
metabolic,
inflammatory
disorders,
disruptions.
This
emphasizes
necessity
multidisciplinary
research
clarify
mechanisms
regulating
EVs.
Язык: Английский