Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope
Molecular Cancer,
Год журнала:
2024,
Номер
23(1)
Опубликована: Ноя. 15, 2024
Normal
life
requires
cell
division
to
produce
new
cells,
but
death
is
necessary
maintain
balance.
Dysregulation
of
can
lead
the
survival
and
proliferation
abnormal
promoting
tumor
development.
Unlike
apoptosis,
necrosis,
autophagy,
newly
recognized
forms
regulated
(RCD)
cuproptosis,
ferroptosis,
PANoptosis
provide
novel
therapeutic
strategies
for
treatment.
Increasing
research
indicates
that
immune
cells
mediated
by
these
discovered
regulate
microenvironment
(TME)
influence
effectiveness
immunotherapy.
This
review
primarily
elucidates
molecular
mechanisms
their
complex
effects
on
TME.
also
summarizes
exploration
nanoparticle
applications
in
therapy
based
vivo
vitro
evidence
derived
from
induction
or
inhibition
RCD
pathways.
Язык: Английский
Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma
Biology,
Год журнала:
2025,
Номер
14(1), С. 61 - 61
Опубликована: Янв. 13, 2025
miRNAs
are
small
non-coding
RNA
molecules
that
play
critical
roles
in
the
regulation
of
gene
expression
and
have
been
closely
associated
with
various
diseases,
including
cancer.
These
significantly
influence
cell
cycle
tumor
cells
control
programmed
death
(apoptosis).
Currently,
research
on
has
become
a
major
focus
developing
cancer
therapies.
Osteosarcoma,
malignant
neoplasm
predominantly
occurring
during
adolescence
later
life,
is
characterized
by
high
propensity
for
metastasis.
This
review
explores
role
initiation
progression
cancer,
highlighting
their
potential
as
predictive
biomarkers
disease.
It
discusses
mechanisms
which
natural
products
modulate
miRNA
activity
to
apoptosis,
ferroptosis,
autophagy
osteosarcoma
cells,
aiming
identify
new
strategies
treatment.
Recent
studies
how
regulate
reduce
resistance
chemotherapy
also
reviewed.
Furthermore,
elaborates
m6A
modifications
expression,
thereby
exerting
antitumor
effects.
In
this
process,
interactions
between
identified,
both
jointly
influencing
tumorigenesis
progression,
offering
perspective
approaches
could
help
uncover
novel
regulatory
pathways
provide
theoretical
foundation
drugs
identifying
therapeutic
targets.
Язык: Английский
Polygonum multiflorum Stilbene Glycoside Oligomers induce the ferroptosis of triple negative breast cancer cells
BMC Cancer,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 14, 2025
The
quality
control
testing
component
and
main
active
ingredient
of
Polygonum
multiflorum
Thunb.
(P.
multiflorum),
known
as
trans-2,3,5,4'-tetrahydroxystilbene
2-O-β-D-glucopyranoside
(TSG),
exhibits
diverse
biological
activities.
In
this
study,
we
report,
for
the
first
time,
potent
ability
TSG
to
induce
ferroptosis
in
triple
negative
breast
cancer
(TNBC)
cell
lines
inhibit
proliferation
TNBC
cells.
Treatment
with
triggers
production
lipid
peroxides,
4-hydroxynonenal
(4-HNE),
reactive
oxygen
species
(ROS)
cells,
indicating
induction
ferroptosis.
Both
vivo
vitro
experiments
confirmed
inhibitory
effects
on
metastasis.
Furthermore,
investigated
other
stilbene
glycoside
oligomers,
alongside
TSG,
lines.
These
compounds
also
demonstrated
suppress
cells'
findings
suggest
that
by
related
could
potentially
serve
a
promising
therapeutic
strategy
treatment.
Язык: Английский