Biomaterials, Год журнала: 2024, Номер 317, С. 123038 - 123038
Опубликована: Дек. 19, 2024
Язык: Английский
Nanomaterials, Год журнала: 2024, Номер 14(7), С. 646 - 646
Опубликована: Апрель 8, 2024
Dressings with multiple functional performances (such as hemostasis, promoting regeneration, analgesia, and anti-inflammatory effects) are highly desired in orthopedic surgery. Herein, several new kinds of medicated nanofibers loaded active ingredients for providing functions were prepared using the modified coaxial electrospinning processes. With an electrospinnable solution composed polycaprolactone fenoprofen core working fluid, different types unspinnable fluids (including pure solvent, nanosuspension containing tranexamic acid hydroxyapatite, dilute polymeric comprising acid, polyvinylpyrrolidone) explored to implement processes creating multifunctional nanofibers. Their morphologies inner structures assessed through scanning transmission electron microscopes, which all showed a linear format without discerned beads or spindles diameter smaller than 1.0 μm, some them had incomplete core–shell nanostructures, represented by symbol @. Additionally, strange details about sheaths’ topographies observed, included cracks, adhesions, embedded nanoparticles. XRD FTIR verified that drugs presented amorphous state, resulted from fine compatibility among involved components. All samples demonstrated have hydrophilic property exhibited lower water contact angle 40° 300 ms. In vitro dissolution tests indicated was released sustained manner over 6 h typical Fickian diffusion mechanism. Hemostatic intentional distribution on shell sections able endow rapid hemostatic effect within 60 s.
Язык: Английский
Процитировано
33
Carbohydrate Polymers, Год журнала: 2024, Номер 347, С. 122738 - 122738
Опубликована: Сен. 13, 2024
Язык: Английский
Процитировано
16
Biomaterials Science, Год журнала: 2024, Номер 12(10), С. 2460 - 2479
Опубликована: Янв. 1, 2024
Due to their distinctive physical and chemical properties as well biological functionalities, multifunctional antibacterial hydrogels possess significant advantages in the treatment of chronic wounds.
Язык: Английский
Процитировано
10
View, Год журнала: 2024, Номер 5(4)
Опубликована: Июль 18, 2024
Abstract With the aging and obesity era, increasing incidence of diabetes diabetic complications, especially non‐healing wounds, imposes a serious economic burden on both patients society. The complex microenvironments, including hyperglycemia, bacterial infection, ischemia, nerve damage, lead to prolonged inflammation proliferation phase wounds. Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs), which contain rich variety therapeutic molecules, have been chased for decades because their potential roles in cellular communication, tissue regeneration, drug delivery. As powerful tools controlled‐sustained release sEVs, biocompatible hydrogels applied wide range biomedical applications. Herein, we first summarize pathological features such as angiopathy, neuropathy, immune cell dysfunction. Then, discuss biological properties, performance, stability pure MSC‐sEVs. After that, components, application patterns, responsiveness hydrogels. Next, loading avenues MSC‐sEVs into hydrogel, behaviors sEVs from hydrogels, influence crosslinking method hydrogel‐sEV composites. Finally, provide an overview current applications loaded with novel cell‐free engineering system managing wounds propose critical unsolved issues. This review is expected meaningful guidance developing wound management.
Язык: Английский
Процитировано
10
Burns & Trauma, Год журнала: 2025, Номер 13
Опубликована: Янв. 1, 2025
Abstract Effective wound management and treatment are crucial in clinical practice, yet existing strategies often fall short fully addressing the complexities of skin healing. Recent advancements tissue engineering have introduced innovative approaches, particularly through use nanobiomaterials, to enhance healing process. In this context, titanium dioxide nanoparticles (TiO2 NPs) garnered attention due their excellent biological properties, including antioxidant, anti-inflammatory, antimicrobial properties. Furthermore, these can be modified therapeutic benefits. Scaffolds dressings containing TiO2 NPs demonstrated promising outcomes accelerating enhancing regeneration. This review paper covers process, properties that make them suitable for promoting healing, methods synthesizing NPs, scaffolds application potential toxicity NPs.
Язык: Английский
Процитировано
1
Carbohydrate Polymers, Год журнала: 2025, Номер 357, С. 123458 - 123458
Опубликована: Март 2, 2025
Язык: Английский
Процитировано
1
Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11
Опубликована: Ноя. 23, 2023
Wound healing is a complex and coordinated biological process easily influenced by various internal external factors. Hydrogels have immense practical importance in wound nursing because of their environmental moisturising, pain-relieving, cooling effects. As photo-crosslinkable biomaterials, gelatine methacryloyl (GelMA) hydrogels exhibit substantial potential for tissue repair reconstruction tunable beneficial properties. GelMA been extensively investigated as scaffolds cell growth drug release biomedical applications. They also hold great significance similarity to the components extracellular matrix skin favourable physicochemical These can promote remodelling reducing inflammation, facilitating vascularisation, supporting growth. In this study, we reviewed applications healing, including engineering, dressing, transdermal delivery. We aim inspire further exploration healing.
Язык: Английский
Процитировано
12
International Wound Journal, Год журнала: 2024, Номер 21(1)
Опубликована: Янв. 1, 2024
Abstract Traumatic haemorrhage is a prevalent clinical condition, and effective timely haemostasis crucial for the preservation of patients' lives. In recent years, injectable hemostatic materials have gained significant attention due to their excellent efficacy, biocompatibility, biodegradability, making them widely applied in treatment incompressible traumatic haemorrhage. Systematic analysis research this area. This article provides comprehensive review development trends over past 20 years using visualization techniques. Analysis collaboration co‐citation networks revealed localized networks, highlighting need enhanced international field materials. Current focuses primarily on materials, processes, mechanisms. Injectable with performance offer promising strategies wound healing. systematic summary offering valuable guidance application novel Additionally, visualized methodology mapping are data mining methods that provide approaches clear knowledge network analysis. These facilitate better understanding interpretation dynamics thereby guiding inspiring future research.
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 274, С. 133218 - 133218
Опубликована: Июнь 18, 2024
Язык: Английский
Процитировано
4
Composites Part B Engineering, Год журнала: 2024, Номер 284, С. 111729 - 111729
Опубликована: Июль 16, 2024
Язык: Английский
Процитировано
4