Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)‐Sensitive Triggers

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(26)

Опубликована: Апрель 17, 2024

Reactive oxygen species (ROS) are critical for cellular signaling. Various pathophysiological conditions also associated with elevated levels of ROS. Hence, ROS-sensitive triggers have been extensively used selective payload delivery. Such applications predicated on two key functions: (1) a sufficient magnitude concentration difference the interested ROS between normal tissue/cells and intended sites (2) appropriate reaction kinetics to ensure level selectivity release. Further, refers group varying reactivity, which should not be viewed as uniform group. In this review, we critically analyze data concentrations different under various examine how affect success linker chemistry. discuss chemistry in context their drug delivery imaging. This review brings new insights into research ROS-triggered delivery, highlights factors consider maximizing chance discusses pitfalls avoid.

Язык: Английский

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Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Science Progress, Год журнала: 2024, Номер 107(1)

Опубликована: Янв. 1, 2024

X-ray computed tomography (CT) and magnetic resonance (MR) imaging are essential tools in modern medical diagnosis treatment. However, traditional contrast agents inadequate the of various health conditions. Consequently, development targeted nano-contrast has become a crucial area focus image-enhancing agents. To fully understand current agents, this review provides an overview preparation methods research advancements CT MR CT/MR multimodal described previous publications. Due to physicochemical properties nanomaterials, such as self-assembly surface modifiability, these specific can greatly improve targeting lesions through clearly highlight distinction between normal tissues both MR. As result, they have potential be used early stages disease diagnostic capacity level imaging.

Язык: Английский

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Photodynamically Tumor Vessel Destruction Amplified Tumor Targeting of Nanoparticles for Efficient Chemotherapy

ACS Nano, Год журнала: 2024, Номер 18(20), С. 12933 - 12944

Опубликована: Май 7, 2024

Efficient tumor-targeted drug delivery is still a challenging and currently unbreakable bottleneck in chemotherapy for tumors. Nanomedicines based on passive or active targeting strategy have not yet achieved convincing chemotherapeutic benefits the clinic due to tumor heterogeneity. Inspired by efficient inflammatory-cell recruitment acute clots, we constructed two-component nanosystem, which composed of an RGD-modified pyropheophorbide-a (Ppa) micelle (PPRM) that mediates vascular-targeted photodynamic reaction activate local coagulation subsequently transmits signals circulating clot-targeted CREKA peptide-modified camptothecin (CPT)-loaded nanodiscs (CCNDs) amplifying targeting. PPRM could effectively bind with vasculature induce sufficient thrombus reaction. Local reaction-induced target amplification greatly increased accumulation CCND 4.2 times, thus significantly enhancing efficacy 4T1 breast model. In other words, this study provides powerful platform amplify tumor-specific taking advantage crosstalk between PPRM-activated cascade CCND.

Язык: Английский

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Acid-Resistant Nano-antioxidants Based on Epigallocatechin Gallate Alleviate Acute Intestinal and Kidney Inflammation

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(35), С. 46090 - 46101

Опубликована: Авг. 22, 2024

Epigallocatechin gallate (EGCG)-based nanosystems have garnered significant attention for their ability to alleviate inflammation due excellent anti-inflammatory properties and enhanced drug delivery capabilities. However, the degradation of EGCG in strongly acidic environments poses a challenge potential administration, particularly oral formulations, where gastric resistance is essential. In this study, we develop "disintegration reorganization" strategy create acid-resistant antioxidant nanoparticles (EGA NPs) based on 5-aminosalicylic acid (5-ASA) mitigating colitis acute kidney injury. At pH, ester bond breaks down, producing two building blocks. These, together with 5-ASA formaldehyde, form oligomers through combination phenol–aldehyde condensation Mannich reaction. The resulting self-assemble into EGA NPs, which exhibit stability under both neutral pH conditions. This makes them suitable allowing withstand harsh conditions, as well intravenous injection. Importantly, these retain EGCG, effectively scavenging reactive oxygen species reducing intracellular oxidative stress. Additionally, shows carrier, efficiently loading agent curcumin (Cur) Cur@EGA NPs. vivo studies demonstrate efficacy alleviating injury following respectively. These nanoparticulate formulations superior reduction compared free Cur vivo. Overall, our findings introduce novel nanoplatform treatment inflammation.

Язык: Английский

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A review on multifaceted biomedical applications of heparin nanocomposites: Progress and prospects

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129379 - 129379

Опубликована: Янв. 17, 2024

Язык: Английский

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