Advancements in nanotechnology for diagnostics: a literature review, part II: advanced techniques in nuclear and optical imaging DOI

Ahmad Butt,

Horacio Bach

Nanomedicine, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Дек. 13, 2024

Modern molecular imaging routes, such as nuclear and optical imaging, derive significant advantages from nanoparticles, where multimodality use multipurpose are key benefits. Nanoparticles also showcase benefits over traditional agents in including improved resolution, penetration, specificity. The goal of this literature review was to explore recent advancements nanomaterials within these techniques expand on the current state nanomedicine modalities. This derives findings relevant reviews, original research papers, in-human clinical trials, patents literature. Au- Fe oxide-based nanosystems just ubiquitous more modern modalities due their multimodal diagnostic therapeutic potential. It is repeatedly highlighted literature, patents, trials that specifically theranostics, present innovative methods years, enabling researchers clinicians overcome limitations unimodal further advancing accuracy diagnosis treatment important pathologies, particularly cancer. Overall, nanoparticle-based represents a transformative approach advanced modalities, offering new approaches conventional currently being applied settings.

Язык: Английский

Cysteine-Specific 18F and NIR Dual Labeling of Peptides via Vinyltetrazine Bioorthogonal Conjugation for Molecular Imaging DOI

Wei Diao,

Jing Lu, Jie Li

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Radiolabeled peptides are vital for positron emission tomography (PET) imaging, yet the 18F-labeling remain challenging due to harsh conditions and time-consuming premodification requirements. Herein, we developed a novel vinyltetrazine-mediated bioorthogonal approach highly efficient 18F-radiolabeling of native peptide under mild conditions. This enabled radiosynthesis various tumor-targeting PET tracers, including targeting neurofibromin receptor (18F-P10a), integrin αvβ3 (18F-P12a), platelet-derived growth factor β (18F-ZPDGFRβ), with radiochemical yield exceeding 90%. Preliminary evaluations revealed excellent hydrophilicity across these 18F-P12a effectively visualizing expression (tumor uptake: 1.57 ± 0.54%ID/g at 2 h). Additionally, explored potential development PET/near-infrared (NIR) dual-labeling agents using this method. The dual-modality agent 18F-Cy5-P12d enables specificity colocalized imaging 1.35 0.24%ID/g Overall, strategy offers versatile platform radiolabeling development.

Язык: Английский

Процитировано

1
Advances in prostate-specific membrane antigen-targeted theranostics: from radionuclides to near-infrared fluorescence technology DOI Creative Commons

Zhongji Jiang,

Gaohaer Kadeerhan, Jin Zhang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 10, 2025

Prostate-Specific Membrane Antigen (PSMA) is a highly expressed and structurally unique target specific to prostate cancer (PCa). Diagnostic therapeutic approaches in nuclear medicine, coupling PSMA ligands with radionuclides, have shown significant clinical success. PSMA-PET/CT effectively identifies tumors metastatic lymph nodes for imaging purposes, while 177Lu-PSMA-617 (Pluvicto) has received FDA approval treating castration-resistant PCa (mCRPC). Despite their success, radionuclide-based diagnostic methods face limitations such as high costs side effects. Recently, near-infrared (NIR) fluorescence phototherapy advanced significantly biomedical applications. It's benefits, deep tissue penetration, real-time precision, minimal effects, driven broader adoption, especially fluorescence-guided surgery (FGS). This review suggests combining NIR dyes enable targeted, high-resolution superior signal-to-background ratios, facilitating precise FGS. techniques can also aid pathological diagnosis ex vivo specimens. Furthermore, photosensitizers allows localized photothermal (PTT) or photodynamic therapy (PDT) under irradiation, producing heat reactive oxygen species (ROS) treat PCa. aims extend the success of targeting by exploring advances NIR-based FGS phototherapy, presenting promising new approach.

Язык: Английский

Процитировано

1
Gastrin-Releasing Peptide Receptor Targeting PET/CT With 68Ga-NOTA-RM26 in the Assessment of Glioma and Combined Multiregional Biopsies DOI
Rongxi Wang, Yilin Li, Ziyang Li

и другие.

Clinical Nuclear Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Purpose The aim of this study was to investigate the value 68 Ga-NOTA-RM26 ( Ga-RM26), a gastrin-releasing peptide receptor–targeting antagonist labeled with radionuclide Ga, in diagnosis high-grade gliomas and combination multiregional biopsies using PET/CT. Patients Methods After institutional review board approval informed consent, total 35 patients suspected glioma lesions were enrolled study. All underwent Ga-RM26 PET/CT scans within 2 weeks before surgery. Results There 8 grade II gliomas, 6 III 18 IV 32 lesions. diagnosed 74.4% (27/32) all tumor types, almost successfully (23/24, 95.8%). Among 9 negative lesions, there low-grade (grade II). significantly higher SUV max , mean lesion-to-background ratio (T/B ratio) compared P < 0.001). In addition, high correlation between immunohistochemical staining score parameters (SUV T/B on 0.001), verified by multiple-point samples guided Conclusions could noninvasively diagnose be promising PET tracer for predicting grading This pilot indicated that uptake correlates WHO glioma, preoperative may helpful guide biopsy gliomas.

Язык: Английский

Процитировано

0
Imaging Strategies for Delineating Glioma Margins: Aiming at Precise Therapy DOI Creative Commons
Jun Tang,

Liangpeng Chen,

Ziyang Li

и другие.

Fundamental Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Dual-Labeled Small Peptides in Cancer Imaging and Fluorescence-Guided Surgery: Progress and Future Perspectives DOI Creative Commons

Patrick G. Minges,

Matthias Eder, Ann-Christin Eder

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 143 - 143

Опубликована: Янв. 22, 2025

Dual-labeled compounds that combine radiolabeling and fluorescence labeling represent a significant advancement in precision oncology. Their clinical implementation enhances patient care outcomes by leveraging the high sensitivity of radioimaging for tumor detection taking advantage fluorescence-based optical visualization surgical guidance. Non-invasive facilitates immediate identification both primary tumors metastases, while imaging assists decision-making during surgery offering spatial distinction between malignant non-malignant tissue. These advancements hold promise enhancing personalization cancer treatment. The development dual-labeled molecular probes targeting various biomarkers is crucial addressing heterogeneity inherent pathology recent studies had already demonstrated impact (NCT03699332, NCT03407781). This review focuses on application small peptides treatment types. It summarizes targeted to date, tracing their from initial discovery latest peptidomimetics. Through comprehensive analysis preclinical studies, demonstrates potential these improve detection, localization, resection. Additionally, it highlights evolving landscape dual-modality imaging, emphasizing its critical role advancing personalized effective therapy. synthesis current research underscores diagnostic accuracy therapeutic

Язык: Английский

Процитировано

0
Diagnostic Value of Gastrin-Releasing Peptide Receptor-Targeted PET Imaging in Oncology: A Systematic Review DOI

Nasibeh Mohseninia,

Roya Eisazadeh, Seyed Ali Mirshahvalad

и другие.

Seminars in Nuclear Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Predicting intraoperative 5-ALA-induced tumor fluorescence via MRI and deep learning in gliomas with radiographic lower-grade characteristics DOI Creative Commons
Eric Suero Molina, Ghasem Azemi, Zeynep Canan Özdemir

и другие.

Journal of Neuro-Oncology, Год журнала: 2024, Номер 171(3), С. 589 - 598

Опубликована: Ноя. 19, 2024

Abstract Purpose Lower-grade gliomas typically exhibit 5-aminolevulinic acid (5-ALA)-induced fluorescence in only 20–30% of cases, a rate that can be increased by doubling the administered dose 5-ALA. Fluorescence depict anaplastic foci, which precisely sampled to avoid undergrading. We aimed analyze whether deep learning model could predict intraoperative based on preoperative magnetic resonance imaging (MRI). Methods evaluated cohort 163 glioma patients categorized intraoperatively as fluorescent (n = 83) or non-fluorescent 80). The MR images lacking high-grade characteristics (e.g., necrosis irregular ring contrast-enhancement) consisted T1, T1-post gadolinium, and FLAIR sequences. preprocessed MRIs were fed into an encoder-decoder convolutional neural network (U-Net), pre-trained for tumor segmentation using those three MRI used outputs bottleneck layer U-Net Variational Autoencoder (VAE) features classification. identified utilized most effective Random Forest classifier principal component analysis (PCA) partial least square discriminant (PLS-DA) algorithms. performance tenfold cross-validation procedure. Results Our proposed approach's was assessed mean balanced accuracy, sensitivity, specificity. optimal results obtained employing top-performing selected PCA, resulting accuracy 80% sensitivity specificity 84% 76%, respectively. Conclusions findings highlight potential model, coupled with classifier, pre-operative prediction fluorescence. achieved high extracted brain segmentation. While still improved, it has evaluating when administer 5-ALA typical radiographic features. Graphical abstract

Язык: Английский

Процитировано

0
Advancements in nanotechnology for diagnostics: a literature review, part II: advanced techniques in nuclear and optical imaging DOI

Ahmad Butt,

Horacio Bach

Nanomedicine, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Дек. 13, 2024

Modern molecular imaging routes, such as nuclear and optical imaging, derive significant advantages from nanoparticles, where multimodality use multipurpose are key benefits. Nanoparticles also showcase benefits over traditional agents in including improved resolution, penetration, specificity. The goal of this literature review was to explore recent advancements nanomaterials within these techniques expand on the current state nanomedicine modalities. This derives findings relevant reviews, original research papers, in-human clinical trials, patents literature. Au- Fe oxide-based nanosystems just ubiquitous more modern modalities due their multimodal diagnostic therapeutic potential. It is repeatedly highlighted literature, patents, trials that specifically theranostics, present innovative methods years, enabling researchers clinicians overcome limitations unimodal further advancing accuracy diagnosis treatment important pathologies, particularly cancer. Overall, nanoparticle-based represents a transformative approach advanced modalities, offering new approaches conventional currently being applied settings.

Язык: Английский

Процитировано

0