Опубликована: Янв. 1, 2024
Язык: Английский
Small, Год журнала: 2024, Номер unknown
Опубликована: Окт. 8, 2024
Abstract The repair and reconstruction of large‐scale bone defects face enormous challenges because the failure to reconstruct osteo‐vascularization network. Herein, a near‐infrared (NIR) light‐responsive hydrogel system is reported achieve programmed tissue regeneration through synergetic effects on‐demand drug delivery mild heat stimulation. spatiotemporal (HG/MPa) composed polydopamine‐coated Ti 3 C 2 T x MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, potent angiogenic drug) hydroxypropyl chitosan/gelatin (HG) developed orchestrate network boost regeneration. Upon exposure NIR light irradiation, engineered HG/MPa can initial complete release aFGF induce rapid angiogenesis provide sufficient blood supply, maximizing its biofunction in defect area. This integrated demonstrated good therapeutic efficacy promoting cell adhesion, proliferation, migration, angiogenesis, osteogenic differentiation periodic irradiation. In vivo, animal experiments further revealed that spatiotemporalized platform synergized photothermal treatment significantly accelerated critical‐sized healing by increasing density, recruiting endogenous stem cells, facilitating production osteogenesis/angiogenesis‐related factors. Overall, smart‐responsive could enhance
Язык: Английский
Процитировано
12
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
ABSTRACT The repair and functional reconstruction of bone defects resulting from trauma, surgical resection, degenerative diseases, congenital malformations are major clinical challenges. Bone tissue engineering has significant advantages in the treatment severe defects. Vascularized scaffolds gradually attracting attention development because their excellent biomimetic properties efficient efficiency. Three‐dimensional (3D) printing technology, which can be used to fabricate structures at different scales using a wide range materials, been production vascularized scaffolds. This review discusses research progress 3D for Angiogenesis‐osteogenesis coupling regeneration process is first introduced, followed by summary technologies, inks, bioactive factors Notably, this focuses on structural design strategies Finally, application medicine, as well challenges outlooks future development, described.
Язык: Английский
Процитировано
1
Composites Part B Engineering, Год журнала: 2025, Номер 297, С. 112252 - 112252
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2024, Номер 45, С. 479 - 495
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
4
Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 98 - 98
Опубликована: Янв. 13, 2025
The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially promoting healing and regeneration. With a deeper understanding the mechanisms defects disorders, LRNs are receiving increasing attention due to their non-invasive, controllable, efficient properties. These materials can regulate cellular biological reactions promote cell adhesion, proliferation, differentiation by absorbing specific wavelengths light converting them into physical chemical signals. In addition, unique surface morphology biocompatibility enable effectively load drugs engineering, achieve precise release, optimize regeneration process. Through photothermal photodynamic therapy, these also possess antibacterial properties play an important role repair infectious defects. Although have shown significant advantages regeneration, series challenges still need be overcome widespread effective clinical applications. This article summarizes basic principles, classification, potential applications aiming provide reference for future research
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160593 - 160593
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер 318, С. 123186 - 123186
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 2743 - 2765
Опубликована: Фев. 1, 2025
The crosstalk between H-type endothelial cells (ECs) and macrophages is critical for maintaining angiogenesis osteogenesis in bone homeostasis. As core components of type H vessels, ECs respond to various pro-angiogenic signals, forming specialized vascular structures characterized by high expression platelet-endothelial cell adhesion molecule-1 (CD31) mucin (EMCN), thereby facilitating angiogenesis-osteogenesis coupling during formation. Macrophages, as key immune the perivascular region, are primarily classified into classically activated pro-inflammatory M1 phenotype selectively anti-inflammatory M2 phenotype, performing dual functions regulating local tissue homeostasis innate immunity. In recent years, complex vessel has garnered significant interest context bone-related diseases. Orderly regulation immunity provides a new direction preventing metabolic disorders such osteoporosis osteoarthritis. However, their interactions remain insufficiently understood, with limited clinical data available. This review comprehensively examines intricate diverse phenotypes, Insights signaling pathways that regulate crosstalk, focusing on roles osteogenesis. Furthermore, discusses interventions targeting this challenges remain. These insights may offer perspectives provide theoretical foundation developing novel therapeutic strategies.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161399 - 161399
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(3), С. 190 - 190
Опубликована: Март 8, 2025
In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional face significant challenges in clinical translation, including brittleness, low mechanical strength, poorly controlled drug degradation rates. To address these limitations, a multifunctional polymer, polydopamine (PDA) has shown great potential both regeneration delivery systems. Its robust adhesive properties, responsiveness photothermal stimulation make it an ideal candidate enhancing hydrogel performance. Integrating PDA into not only improves properties but also creates environment conducive cell adhesion, proliferation, differentiation, thereby promoting repair. Moreover, facilitates release, offering approach optimizing treatment outcomes. This paper first explores the mechanisms through which promotes regeneration, laying foundation its translation. Additionally, discusses application of PDA-based nanocomposite advanced systems repair, providing valuable insights research
Язык: Английский
Процитировано
0