Gender Disparities in Neurological Symptoms of Long-COVID: A systematic review and meta-analysis

Neuroepidemiology, Год журнала: 2024, Номер unknown, С. 1 - 15

Опубликована: Авг. 19, 2024

Background: Female gender is a known risk factor for long COVID. With the increasing number of COVID-19 cases, corresponding survivors also expected to rise. To best our knowledge, no systematic review has specifically addressed differences in neurological symptoms Methods: We included studies on female individuals who presented with specific at least 12 weeks after confirmed diagnosis from PubMed, Central, Scopus, and Web Science. The search limit was put January 2020 until June 15, 2024. excluded that did not provide sex-specific outcome data, those English, case reports, series, articles Results: A total 5,632 eligible were identified. This article provides relevant information involving 6,849 patients, which 3,414 female. sample size ranged 70 2,856, maximum follow-up period 18 months. earliest publication date September 16, 2021, while latest 11, following had significant difference ratio (RR) gender: fatigue RR 1.40 (95% confidence interval [CI]: 1.22–1.60, p < 0.001), headache 1.37 CI: 1.12–1.67, = 0.002), brain-fog 1.38 CI 1.08–1.76, 0.011) depression 1.49 1.2–1.86, anosmia 1.61 1.36–1.90, 0.001). High heterogenicity found fatigue, brain fog, anxiety due diverse methodologies employed studies. Conclusion: Our findings suggest women are higher long-COVID symptoms, including headaches, depression, anosmia, compared men. prevalence these decreases 1 year, based limited data small available beyond this period.

Язык: Английский

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Thematic analysis to explore patients’ experiences with long COVID-19: a conceptual model of symptoms and impacts on daily lives

BMJ Open, Год журнала: 2024, Номер 14(1), С. e076992 - e076992

Опубликована: Янв. 1, 2024

Objectives There is limited qualitative research on patients’ experiences with long COVID-19, and how specific symptoms impact their daily lives. The study aimed to understand lived of COVID-19 develop a conceptual model representing the overall quality life. Setting Qualitative consisting comprehensive literature review, in-depth clinician patient semistructured interviews. Participants Forty-one adult patients whom 18 (44%) were recruited through Regeneron Pharmaceuticals’s clinical trials 23 (56%) recruitment agencies; 85.4% female 73.2% White. Five independent clinicians treating interviewed. Concept saturation was also assessed. Primary secondary outcomes Interview transcripts analysed thematically identify concepts interest spontaneously mentioned by patients, including impacts life, guide development model. Results Findings from review interviews resulted in comprising two overarching domains: (upper respiratory tract, lower smell taste, systemic, gastrointestinal, neurocognitive other) (activities living, instrumental activities physical impacts, emotional, social/leisure professional impacts). Saturation achieved for reported impacts. heterogenic; symptoms, such as numbness, ringing ears, haziness, confusion, forgetfulness/memory problems, brain fog, concentration, difficulties finding right word challenges fine motor skills, particularly pertinent several months. Conclusion model, developed based experience data highlighted numerous that mental well-being, suggests humanistic unmet needs. Prospective real-world studies are warranted pattern experienced larger samples over longer periods time.

Язык: Английский

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Paxlovid as a potential treatment for long COVID

Expert Opinion on Pharmacotherapy, Год журнала: 2023, Номер 24(17), С. 1839 - 1843

Опубликована: Сен. 21, 2023

On 31 July 2023, the United States Department of Health and Human Services announced formation Office Long COVID Research Practice National Institutes opened enrollment for RECOVER-Vital, a randomized study to evaluate new treatment options long Coronavirus (long COVID).The RECOVER Initiative is $1.15 billion research platform intended describe, categorize, treat, prevent long-term symptoms following infection by Severe Acute Respiratory Syndrome 2 (SARS‑CoV‑2), virus that causes (COVID-19). More than 200 have been associated with COVID, potentially affecting nearly all body systems, current estimates suggest between 7 million 23 Americans developed COVID. However, there are no approved treatments this condition.The first prospective, initiative, will SARS-CoV-2 antiviral nirmatrelvir/ritonavir (Paxlovid) as potential This manuscript explores what known about Paxlovid treat examines rationale addressing condition an agent.

Язык: Английский

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Characteristics and burden of acute COVID-19 and long-COVID: Demographic, physical, mental health, and economic perspectives

PLoS ONE, Год журнала: 2024, Номер 19(1), С. e0297207 - e0297207

Опубликована: Янв. 22, 2024

Background COVID-19 infection and its associated consequence, known as long-COVID, lead to a significant burden on the global healthcare system limitations in people’s personal work lives. This study aims provide further insight into impact of acute ongoing symptoms investigates role patients’ gender vaccination status. Methods 416 individuals (73.9% female) between ages 16 80 years ( M = 44.18, SD 12.90) with self-reported long-COVID participated an online survey conducted March May 2022. Results 6.0%, 74.3%, 19.7% all respondents reported having had asymptomatic, mild, or severe illness, respectively. Out participants, 7.8% required hospitalization. The most prevalent during Mdn 23.50 symptoms, IQR 13–39) included fatigue, exhaustion, cough, brain fog, memory problems. median disease duration was 12.10 months 2.8–17.4). Among 64 inquired 17.00 9–27), participants problems, dyspnea common which were generally experienced fluctuating deteriorating after physical cognitive activity. Common consequences financial losses (40.5%), changes participants’ profession (41.0%), stress resistance (87.5%), sexual life (38.1%), mood (72.1%), well breathing difficulties (41.3%), increased drug intake (e.g., medicine, alcohol; 44.6%). In addition, vaccinated exhibited shorter illness earlier onset symptoms. general, women more than men. Conclusion Long-COVID represents heterogeneous impacts multiple aspects those affected. Tailored rehabilitation programs targeting plurality mental are needed.

Язык: Английский

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Proposal and Definition of an Intelligent Clinical Decision Support System Applied to the Prediction of Dyspnea after 12 Months of an Acute Episode of COVID-19

Biomedicines, Год журнала: 2024, Номер 12(4), С. 854 - 854

Опубликована: Апрель 12, 2024

Long COVID is a condition that affects significant proportion of patients who have had COVID-19. It characterised by the persistence associated symptoms after acute phase illness has subsided. Although several studies investigated risk factors with long COVID, identifying which will experience long-term remains complex task. Among various symptoms, dyspnea one most prominent due to its close association respiratory nature COVID-19 and disabling consequences. This work proposes new intelligent clinical decision support system predict 12 months severe episode based on SeguiCovid database from Álvaro Cunqueiro Hospital in Vigo (Galicia, Spain). The initially processed using CART-type tree identify variables highest predictive power. Based these variables, cascade expert systems been defined Mamdani-type fuzzy-inference engines. rules for each were generated Wang-Mendel automatic rule generation algorithm. At output cascade, indicator obtained, allows categorisation into two groups: those without at months. simplifies follow-up performance aimed risk. produced satisfactory results initial tests, supported an AUC 0.75, demonstrating potential usefulness this tool practice.

Язык: Английский

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Prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province: a population-based prospective study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Coronavirus disease 2019 (COVID-19) can lead to persistent symptoms, sequelae, and other medical complications that may last for weeks or months after recovery. The aim of the study is assess prevalence risk factors long COVID-19 persisting 2 years in Hainan Province, China, aid its recognition, prevention, treatment. Between July August 2022, 960 individuals with confirmed SARS-CoV-2 infection Hainan, were recruited. An epidemiological questionnaire was conducted via phone interviews participants' recovery status years. Among participants, 120 patients (12.5%) experienced at least one complication. most common symptoms cough (33.3%, 40/120), followed by fatigue (25.9%, 31/120), hair loss (23.3%, 28/120), dizziness (20.8%, 25/120). Independent included age over 65, moderate severe infection, chronic diseases, irregular diet, late sleeping, anxiety, fewer than vaccinations (p < 0.05). While infected fully recover, approximately 12.5% experience intermediate long-term effects. This first identify incidence associated longest follow-up time, providing valuable insights timely restoration pre-COVID-19 health.

Язык: Английский

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Post-infection symptoms up to 24 months after COVID-19: a matched cohort study in Berlin, Germany

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Март 12, 2025

Introduction Long-term health consequences after mild COVID-19 are not well described. Our aim was to estimate their prevalence and describe the time course of signs symptoms for a period up 24 months SARS-CoV-2 infection. Methods We conducted cohort study matched age, sex, test week among individuals who had attended public center at Charité—Universitätsmedizin Berlin, Germany. In early 2022, 576 former patients (&gt;95% non-hospitalized) 302 uninfected responded questionnaire on retrospective monthly since date ago. Results Symptoms compatible with long COVID were present in 42.9% (247/576) patients, compared 21.2% (64/302) group. unadjusted odds ratios (OR) highest disturbed taste/smell (OR 9.1 [95% CI: 4.0–21.1]), memory difficulties 5.1 2.9–8.9]), shortness breath rest 4.5 1.9–10.6]). most occurred one coherent resolved median 6.5 months, while disturbance neurological/cognitive showed longer times until recovery. Factors associated COVID-compatible included hospitalization, symptomatic infection, low household income female sex. Conclusion Post-infection mostly persist about half year, but sometimes longer. Among never experienced COVID-19, also reported symptoms. The current definition might require revision prevent misclassification over-reporting, improve diagnosis estimates.

Язык: Английский

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Neuropsychiatric sequelae in an experimental model of post-COVID syndrome in mice

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Unravelling the complex and unexpected physiopathology of the post COVID-19 condition: a narrative review

Discover Viruses., Год журнала: 2025, Номер 2(1)

Опубликована: Май 7, 2025

Язык: Английский

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Determinants of work ability among health and social services workers with work-related COVID-19 infection in Germany

BMC Health Services Research, Год журнала: 2025, Номер 25(1)

Опубликована: Июнь 3, 2025

Язык: Английский

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