Опубликована: Янв. 1, 2024
Язык: Английский
PeerJ, Год журнала: 2025, Номер 13, С. e19063 - e19063
Опубликована: Фев. 27, 2025
Background Triple-negative breast cancer (TNBC) is an aggressive subtype with a poor prognosis. Although circular RNAs (circRNAs) have been implicated in progression, their roles TNBC remain poorly understood. In this study, we aimed to develop prognostic model for by constructing competing endogenous RNA (ceRNA) network. This network integrates circRNAs, long noncoding (lncRNAs), microRNAs (miRNAs), and messenger (mRNAs) identify potential biomarkers therapeutic targets improving clinical outcomes. Methods Differentially expressed lncRNAs, mRNAs were identified from GEO datasets (144 samples: 94 50 normal tissues). A ceRNA was constructed, key genes validated using The Cancer Genome Atlas (TCGA) dataset (115 113 para-cancer Multivariate Cox regression analysis performed model, Gene Set Enrichment Analysis (GSEA) associated pathways. Results Nine ( SH3BGRL2 , CA12 LRP8 NAV3 GFRA1 DCDC2 CDC7 ABAT NPTX1 ) as factors the which demonstrated area under curve (AUC) of 0.90. Patients classified high-risk patients exhibited significantly shorter overall survival (median OS: 8.12 years vs . 9.51 years, P < 0.01). mitogen-activated protein kinase (MAPK) signaling pathway regulatory pathway, circRNAs (hsa_circ_0005455, hsa_circ_000632, hsa_circ_0001666, hsa_circ_0000069) regulating expression. Conclusion study developed novel based on analysis, highlighting critical role MAPK progression. These findings offer valuable insights into prognosis reveal promising patient
Язык: Английский
Процитировано
0
Therapeutic Advances in Medical Oncology, Год журнала: 2025, Номер 17
Опубликована: Янв. 1, 2025
Limited real-world efficacy and safety data exist regarding the use of trastuzumab deruxtecan (T-DXd) in Chinese population with human epidermal growth factor receptor (HER2)-positive HER2-low advanced breast cancer (BC). This multicenter, observational, study aimed to evaluate T-DXd for treatment patients HER2-positive BC. The medical records 61 were collected from Second Hospital Dalian Medical University, Beijing Chaoyang District Sanhuan Cancer Hospital, Jingxin Academy Sciences. primary endpoint was progression-free survival (PFS), secondary endpoints overall (OS), objective response rate (ORR), disease control (DCR), time (TTR), safety. PFS OS analyzed using Kaplan-Meier method log-rank test. endpoint, 10.51 months (95% confidence interval (CI), 3.02-NE) group 10.18 CI, 3.88-NE) group. Regarding groups, immature, ORR rates 37.93% 62.50%, DCR 79.31% 87.50%, median TTR 1.28 1.31 months, respectively. In subgroup analysis, front-line associated increased beneficial effects. adverse events (AEs) related gastrointestinal reactions bone marrow suppression, which predominantly grades 1-2, no severe grade 4/5 AEs reported, only one patient developed infectious pneumonia. first BC China. findings demonstrated that may be an effective antitumor controllable irrespective HER2 expression levels.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2773 - 2773
Опубликована: Март 19, 2025
Tumors formed by the unchecked growth of breast cells are known as cancer. The second most frequent cancer in world is It common among females. In 2022, 2,296,840 women were diagnosed with therapy evolving through development Poly (ADP-ribose) polymerase (PARP) inhibitors, which offering people specific genetic profiles new hope research into disease continues. focuses on patients BRCA1 and BRCA2 mutations. This review summarizes recent mechanisms action PARP inhibitors their implications for therapy. We how therapeutic applications developing highlight studies showing effectiveness these medicines whether used alone or combination. Furthermore, significance customized highlighted enhancing patient outcomes we address function testing identifying candidates inhibition. Recommendations future areas to maximize potential also included, along challenges limits clinical usage. objective this improve our comprehension complex interaction between biology knowledge will help guide screening approaches, practice, support preventive initiatives at risk.
Язык: Английский
Процитировано
0
Asia-Pacific Journal of Oncology Nursing, Год журнала: 2025, Номер 12, С. 100700 - 100700
Опубликована: Апрель 15, 2025
This study aimed to identify latent classes of online health information seeking (OHIS) behaviors among young women diagnosed with breast cancer in China and examine associated personal characteristics support tailored education strategies. Young were recruited from a center between April September 2024. Participants completed questionnaires on demographic clinical characteristics, OHIS behaviors, psychosocial cognitive factors, trust, social norms, communication, experience. Latent class analysis (LCA) identified patterns, multivariate logistic regression explored characteristics. Among the 398 patients, median number topics sought was 5 (4-7). The most frequently related included basic knowledge (89.7%), treatment plans (77.6%), lifestyle (75.4%). Nearly half only few times month or less. Social media (82.7%) official accounts/websites (71.1%) used sources. LCA revealed three behavior classes: Class 1 "information explorers" (26.4%), 2 "occasional seekers" (49.2%), 3 experts" (24.4%). Patients adjuvant other phases more likely belong than 1. Those longer time since diagnosis also be classified into 3. Conversely, stage I patients those who trusted 1, while higher eHealth literacy membership. display diverse patterns influenced by factors. Recognizing these differences is vital for delivering services.
Язык: Английский
Процитировано
0
Journal of Health Population and Nutrition, Год журнала: 2025, Номер 44(1)
Опубликована: Май 24, 2025
Alcoholic cardiomyopathy (ACM) results from chronic alcohol misuse and primarily affects the working-age population (15-64 years). The global age-standardized rates (ASRs) of ACM disease burden declined slightly 1990 to 2021, but absolute cases increased, especially in high‒medium sociodemographic index (SDI) regions such as Eastern Europe. aim this study was inform strategies combat preventable yet escalating health issue. We calculated estimated annual percentage changes (EAPCs) quantify dynamics prevalence, deaths, disability-adjusted life years (DALYs) for ACM. Decomposition analysis quantifies contributor Additionally, we employed a inequality with two core indicators, slope (SI) concentration (CIN), assess national differences relation SDI. Frontier used identify burdens respect optimized policies, particularly high-middle SDI countries. Finally, applied Bayesian age‒cohort (BAPC) model project 2035. This revealed that ASRs DALYs decreased whereas continued increase globally. Global income-based disparities have intensified over past 32 years, high populations disproportionately favoured. Population growth main driver increased burden. is expected future according BAPC model. continues rise, due ageing insufficient prevention policies. impacts populations, who face heightened vulnerability accessibility, premature mortality, reduced workforce productivity. Moreover, economic paradoxically coincides alcohol-related harm socioeconomic development-the control paradox. Projections highlight an urgent need tailored strategies, including stricter regulation early cardiac screening high-risk groups, mitigate productivity loss align public priorities sustainable development goals.
Язык: Английский
Процитировано
0
Journal of Molecular Structure, Год журнала: 2024, Номер 1321, С. 140214 - 140214
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0