Mediating role of the ratio of family income to poverty in the association between depressive symptoms and stroke: Evidence from a large population-based study
Journal of Affective Disorders,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Building a cancer risk and survival prediction model based on social determinants of health combined with machine learning: A NHANES 1999 to 2018 retrospective cohort study
Medicine,
Год журнала:
2025,
Номер
104(6), С. e41370 - e41370
Опубликована: Фев. 7, 2025
The
occurrence
and
progression
of
cancer
is
a
significant
focus
research
worldwide,
often
accompanied
by
prolonged
disease
course.
Concurrently,
researchers
have
identified
that
social
determinants
health
(SDOH)
(employment
status,
family
income
poverty
ratio,
food
security,
education
level,
access
to
healthcare
services,
insurance,
housing
conditions,
marital
status)
are
associated
with
the
many
chronic
diseases.
However,
there
paucity
examining
influence
SDOH
on
incidence
risk
survival
survivors.
aim
this
study
was
utilize
as
primary
predictive
factor,
integrated
machine
learning
models,
forecast
both
prognostic
survival.
This
grounded
in
data
derived
from
National
Health
Nutrition
Examination
Survey
dataset
spanning
1999
2018.
It
employs
methodologies
including
adaptive
boosting,
gradient
boosting
(GradientBoosting),
random
forest
(RF),
extreme
light
machine,
support
vector
logistic
regression
develop
models
for
predicting
hyperparameters
these
models—specifically,
number
estimators
(100–200),
maximum
tree
depth
(10),
rate
(0.01–0.2),
regularization
parameters—were
optimized
through
grid
search
cross-validation,
followed
performance
evaluation.
Shapley
Additive
exPlanations
plots
were
generated
visualize
each
feature.
RF
best
model
(area
under
curve:
0.92,
accuracy:
0.84).
Age,
non-Hispanic
White,
sex,
status
4
most
important
characteristics
model.
gender,
employment
household
income/poverty
ratio
features
developed
exhibited
strong
estimating
time,
identifying
several
factors
significantly
survival,
thereby
providing
new
evidence
management.
Despite
promising
findings,
acknowledges
certain
limitations,
omission
survivor
potential
biases
inherent
dataset.
Future
warranted
further
validate
using
external
datasets.
Язык: Английский
Vascular Cognitive Impairment—The Molecular Basis and Potential Influence of the Gut Microbiota on the Pathological Process
Cells,
Год журнала:
2024,
Номер
13(23), С. 1962 - 1962
Опубликована: Ноя. 27, 2024
Cognitive
impairment
is
a
major
healthcare
challenge
worldwide,
with
vascular
cognitive
(VCI)
being
its
second
leading
cause
after
Alzheimer’s
disease.
VCI
heterogeneous
group
of
disorders
resulting
from
various
pathologies.
Therefore,
it
particularly
difficult
to
determine
underlying
and
exact
molecular
basis.
Nevertheless,
the
current
understanding
pathophysiological
processes
has
changed
evolved
in
last
decades.
The
aim
this
narrative
review
summarize
state
knowledge
on
pathogenesis
analyze
potential
role
gut
microbiota
process,
considering
most
recent
scientific
reports
accordance
these
processes.
Chronic
cerebral
hypoperfusion,
which
results
impaired
blood
supply,
i.e.,
oxygen
nutrient
deficiency,
main
mechanism
VCI.
Furthermore,
chronic
hypoperfusion
triggers
cascade
changes,
starting
an
energy
imbalance,
glutamate
excitotoxicity,
acidotoxicity,
oxidative
stress.
Also,
all
above
provoke
activation
microglia
release
pro-inflammatory
cytokines
that
recruit
systemic
immune
cells
lead
their
infiltration
into
central
nervous
system,
neuroinflammation.
Blood–brain
barrier
dysfunction
may
occur
at
stages
ultimately
increasing
permeability
allowing
potentially
toxic
substances
enter
brain
parenchyma.
Gut
metabolites,
have
been
identified
numerous
inflammatory
conditions,
also
influence
Язык: Английский
Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
unknown, С. 117802 - 117802
Опубликована: Янв. 1, 2025
Язык: Английский
Letter to the editor regarding: ‘increased purchases of prescription medicines in offspring of women with type 1 diabetes: a Finnish register-based cohort study between 1995 and 2018’
Annals of Medicine,
Год журнала:
2024,
Номер
57(1)
Опубликована: Дек. 31, 2024
Язык: Английский