Cognitive profile, neuroimaging and fluid biomarkers in post-acute COVID-19 syndrome

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 5, 2024

Abstract We aimed to characterize the cognitive profile of post-acute COVID-19 syndrome (PACS) patients with complaints, exploring influence biological and psychological factors. Participants confirmed SARS-CoV-2 infection complaints ≥ 8 weeks phase were included. A comprehensive neuropsychological battery (NPS) health questionnaires administered at inclusion 1, 3 6 months. Blood samples collected each visit, MRI scan baseline months, and, optionally, cerebrospinal fluid. Cognitive features analyzed in relation clinical, neuroimaging, biochemical markers follow-up. Forty-nine participants, a mean time from symptom onset 10.4 showed attention-executive function (69%) verbal memory (39%) impairment. Apathy (64%), moderate-severe anxiety (57%), severe fatigue (35%) prevalent. Visual (8%) correlated total gray matter (GM) subcortical GM volume. Neuronal damage inflammation within normal limits. Over time, test scores, depression, apathy, indexes, fluid biomarkers remained stable, although fewer participants (50% vs. 75.5%; p = 0.012) exhibited abnormal evaluations Altered attention/executive memory, common PACS, persisted most subjects without association structural abnormalities, elevated cytokines, or neuronal markers.

Язык: Английский

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Adaptation and normative data of the cognitive assessment battery of language (BECLA-Tr) for the Turkish adult population

Aphasiology, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 15, 2025

Introduction Normal cognitive aging is identified from pathological through the administration of neuropsychological tests, including tests language ability. Compared to English, available and test batteries for assessing acquired deficits in Turkish speakers are much more limited. This study reports on adaptation generation normative data The Batterie d'Évaluation Cognitive du Langage (BECLA) adult population.

Язык: Английский

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Long-term neuropsychological consequences of severe COVID-19 infection: the NEUROCOG-COVID study

Journal of Neurology, Год журнала: 2025, Номер 272(5)

Опубликована: Апрель 28, 2025

Abstract Background Recent studies have confirmed the presence of cognitive disorders, which may be maintained over long term and associated with psychological disorders following COVID-19 infection. The aim our study was to characterize long-term psychiatric in patients younger than 65 years hospitalized for severe Methods All who were between October 2020 July 2021 infection a complaint according QPC questionnaire selected. They underwent systematic neuropsychological evaluation assessing functions, processes, quality life (QOL). Results offered 293 patients, 129 whom had complaint. A total 74 (57% men) these aged approximately 55 years, undergone full 337.38 ± 25.11 days after hospital discharge. Seventy-three percent presented including executive (66%), memory (31%), language (19%), other instrumental (12%). Single-domain impairment found 54% predominantly “dysexecutive syndrome” (83%) profile. There no difference groups concerning impairment. Patients profile reported poorer mental QOL did ( p < .05). Conclusions Cognitive are common COVID-19. consideration factors is essential management COVID-19, especially considering their impact on patients' QOL. Comprehensive assessment helps identify contributing complaints optimize multidisciplinary management, particularly when not related testing.

Язык: Английский

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Long-term cognitive functioning following COVID-19: Negligible neuropsychological changes over time

The Clinical Neuropsychologist, Год журнала: 2025, Номер unknown, С. 1 - 19

Опубликована: Май 2, 2025

Objective: Objective cognitive impairment has been shown in a minority of hospitalized COVID-19 patients, and longitudinal studies with relatively long follow-up duration are scarce. We sought to investigate the presence long-term change objective functioning. Method: Forty-six initially (18 ± 19 days) survivors (male/female: 30/16; age: 61 11) underwent extensive neuropsychological assessment (including performance validity) approximately 1 (T1) 2.5 years (T2) post-infection. Cognitive domains assessed were: memory, attention, executive functioning, processing speed, language (n = 14 (sub)tests). used normative data derive age, sex, education-adjusted T-scores (T ≤ 35 [≤-1.5SD], deficit cut-off). Repeated measures AN(C)OVAs were functioning over time. Results: Mean tests) was within normal range at both timepoints, number individuals deficits ranged from 0-20% (T1), 2-22% (T2). Number subjective complaints remained unchanged. A (17%) showed on ≥2 tests post-infection, but not consistently one domain. Longitudinal analyses total sample improvement time phonemic fluency (p<.001), stable all other tests, independent prior comorbidities, complaints, depressive symptoms, ICU admission. Conclusions: There no consistent or major disorders after SARS-CoV-2 infection majority cases. Neuropsychological essentially unchanged Future larger necessary unravel COVID-19-related phenotypes persisting how these can be modulated.

Язык: Английский

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Impact of inflammatory response in the acute phase of COVID-19 on predicting objective and subjective post-COVID fatigue

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 28, 2024

The biological predictors of objective and subjective fatigue in individuals with post-COVID syndrome remains unclear. This study aims to ascertain the predictive significance immune response measured during acute phase SARS-CoV-2 infection on various dimensions 6–9 months post-infection. We examined association between markers obtained from serum 54 patients (mean age: 58.69 ± 10.90; female: 31%) chronic using general linear mixed models. Level IL-1RA, IFNγ TNFα plasma percentage monocytes COVID-19 predicted physical total fatigue. Moreover, higher concentration (r=-0.40 ; p = .019) phase, greater lack awareness cognitive These findings shed light relationship inflammatory persistence both

Язык: Английский

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Self-Other Voice Discrimination Task: A Potential Neuropsychological Tool For Clinical Assessment of Self-Related Deficits

Heliyon, Год журнала: 2024, Номер 10(19), С. e38711 - e38711

Опубликована: Окт. 1, 2024

Язык: Английский

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Response to: Limbic system damage following SARS-CoV2 infection

Brain Communications, Год журнала: 2023, Номер 5(6)

Опубликована: Янв. 1, 2023

Язык: Английский

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