Coffee drinking timing and mortality in US adults

European Heart Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Abstract Background and Aims To identify the patterns of coffee drinking timing in US population evaluate their associations with all-cause cause-specific mortality. Methods This study included 40 725 adults from National Health Nutrition Examination Survey 1999–2018 who had complete information on dietary data 1463 Women’s Men’s Lifestyle Validation Study 7-day record. Clustering analysis was used to timing. Results In this observational study, two distinct [morning type (36% participants) all-day-type (14% participants)] were identified validated Study. During a median (interquartile range) follow-up 9.8 (9.1) years, total 4295 deaths, 1268 cardiovascular disease 934 cancer deaths recorded. After adjustment for caffeinated decaffeinated intake amounts, sleep hours, other confounders, morning-type pattern, rather than significantly associated lower risks (hazard ratio: .84; 95% confidential interval: .74–.95) disease-specific .69; .55–.87) mortality as compared non-coffee drinking. Coffee modified association between amounts (P-interaction = .031); higher risk participants pattern but not those pattern. Conclusions Drinking morning may be more strongly later day.

Язык: Английский

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Coffee or tea: Anti-inflammatory properties in the context of atherosclerotic cardiovascular disease prevention

Pharmacological Research, Год журнала: 2022, Номер 187, С. 106596 - 106596

Опубликована: Дек. 5, 2022

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of premature death worldwide. Inflammation and its biomarkers, like C-reactive protein (CRP), among risk factors, such as hypertension, lipid disorders, diabetes, may be also responsible for residual (CVD) risk. Modern lipid-lowering treatment with statins, ezetimibe, PCSK9 inhibitors, or bempedoic acid does not fully protect against inflammation. The recommendations International Lipid Expert Panel (ILEP) indicate selected nutraceuticals anti-inflammatory properties. Diet have a significant impact on Especially interesting in context inflammation consumption coffee tea. These drinks many observational studies significantly reduced mortality. question whether effects these contribute to observed clinical effects. Thus, this narrative review, we primarily discuss properties consuming tea coffee. Based comprehensive analysis their meta-analyses, inconsistent results were obtained, which makes it impossible conclusively state how clinically potential black green are. A number confounding factors can inconsistency available results. Consumption appears increase adiponectin concentrations, decrease reactive oxygen species, low density lipoprotein (LDL) cholesterol concentrations (effect tea, etc.). Despite still uncertain effect coffee, recommend part healthy diet.

Язык: Английский

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Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2706 - 2706

Опубликована: Янв. 31, 2023

Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies associate higher coffee consumption with decreased rates mortality neurological metabolic diseases, including Parkinson's disease type 2 diabetes. In addition, there also evidence that associated lower colon rectal cancer, as well breast, endometrial, other cancers, although for some these results are conflicting. These reflect chemopreventive effects coffee; may be therapeutic forms breast this needs to further investigated. The mechanisms or chemotherapeutic over 1000 individual compounds in roasted complex vary different diseases. Some related nuclear factor erythroid (Nrf2)-regulated pathways target oxidative stress induce reactive oxygen species kill diseased cells (primarily therapeutic). There involvement receptors which include aryl hydrocarbon receptor (AhR) orphan 4A1 (NR4A1), contributions from epigenetic gut microbiome. Further elucidation will facilitate potential future clinical applications extracts treating cancer inflammatory

Язык: Английский

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Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans

Nature Human Behaviour, Год журнала: 2023, Номер 7(8), С. 1357 - 1370

Опубликована: Июнь 29, 2023

Язык: Английский

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Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence

Regulatory Toxicology and Pharmacology, Год журнала: 2023, Номер 139, С. 105369 - 105369

Опубликована: Март 1, 2023

Several toxicological and epidemiological studies were published during the last five decades on non-sugar sweeteners (NSS) cancer. Despite large amount of research, issue still continues to be interest. In this review, we provided a comprehensive quantitative review evidence possible relation between NSS The section includes evaluation genotoxicity carcinogenicity data for acesulfame K, advantame, aspartame, cyclamates, saccharin, steviol glycosides sucralose. results systematic search cohort case-control studies. majority 22 46 showed no associations. Some risks bladder, pancreas hematopoietic cancers found in few not confirmed other Based both experimental or specific evaluated, it can concluded that there is cancer risk associated consumption.

Язык: Английский

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Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts

Nature Microbiology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Abstract Although diet is a substantial determinant of the human gut microbiome, interplay between specific foods and microbial community structure remains poorly understood. Coffee habitually consumed beverage with established metabolic health benefits. We previously found that coffee is, among >150 items, food showing highest correlation microbiome components. Here we conducted multi-cohort, multi-omic analysis US UK populations detailed dietary information from total 22,867 participants, which then integrated public data 211 cohorts ( N = 54,198). The link consumption was highly reproducible across different (area under curve 0.89), largely driven by presence abundance species Lawsonibacter asaccharolyticus . Using in vitro experiments, show can stimulate growth L. Plasma metabolomics on 438 samples identified several metabolites enriched consumers, quinic acid its potential derivatives associated This study reveals microorganism item, providing framework for understanding responses at biochemical level.

Язык: Английский

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Sweetened Beverages, Genetic Susceptibility, and Incident Atrial Fibrillation: A Prospective Cohort Study

Circulation Arrhythmia and Electrophysiology, Год журнала: 2024, Номер 17(3)

Опубликована: Март 1, 2024

BACKGROUND: An association between sweetened beverages and several cardiometabolic diseases has been reported, but their with atrial fibrillation (AF) is unclear. We aimed to investigate the associations consumption of sugar-sweetened (SSB), artificially (ASB), pure fruit juice (PJ) risk AF further evaluate whether genetic susceptibility modifies these associations. METHODS: A total 201 856 participants who were free baseline AF, had data available, completed a 24-hour diet questionnaire included. Cox proportional hazard models used estimate ratios (HRs) 95% confidence intervals (CIs). RESULTS: During median follow-up 9.9 years, 9362 incident cases documented. Compared nonconsumers, individuals consumed >2 L/wk SSB or ASB an increased (HR, 1.10 [95% CI, 1.01–1.20] HR, 1.20 1.10–1.31]) in multivariable-adjusted model. negative was observed ≤1 PJ 0.92 0.87–0.97]). The highest HRs (95% CIs) for at high 3.51 2.94–4.19]), lowest HR those low 0.77 0.65–0.92]). No significant interactions SSB, ASB, predisposition AF. CONCLUSIONS: Consumption associated modestly lower persisted after adjustment This study does not demonstrate that alters rather may predict beyond traditional factors.

Язык: Английский

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Coffee Consumption, Additive Use, and Risk of Type 2 Diabetes– Results from Three Large Prospective US Cohort Studies

American Journal of Clinical Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Consumption of Unsweetened Coffee or Tea May Reduce the Cancer Incidence and Mortality: A Prospective Cohort Study

Journal of Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Consumption of coffee and tea with all-cause and cause-specific mortality: a prospective cohort study

BMC Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Ноя. 18, 2022

Abstract Background Previous studies suggested that moderate coffee and tea consumption are associated with lower risk of mortality. However, the association between combination mortality remains unclear. This study aimed to evaluate separate combined associations all-cause cause-specific Methods prospective cohort included 498,158 participants (37–73 years) from UK Biobank 2006 2010. Coffee were assessed at baseline using a self-reported questionnaire. All-cause mortalities, including cardiovascular disease (CVD), respiratory disease, digestive mortality, obtained national death registries. Cox regression analyses conducted estimate hazard ratios (HRs) 95% confidence intervals (CIs). Results After median follow-up 12.1 years, 34,699 deaths identified. The attributable CVD, nonlinear (all P < 0.001). was J-shaped, whereas reverse J-shaped. Drinking one cup or three cups per day seemed link lowest In joint analyses, compared neither nor consumption, 1–2 cups/day 2–4 had risks for (HR, 0.78; CI: 0.73–0.85), CVD 0.76; 0.64–0.91), 0.69; 0.57–0.83) Nevertheless, HR (95% CI) drinking both cup/day ≥ 5 0.42 (0.34–0.53). Conclusions this large study, inversely

Язык: Английский

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