Thrombosis and Haemostasis,
Год журнала:
2024,
Номер
124(12), С. 1143 - 1151
Опубликована: Май 10, 2024
Objective
The
association
between
tea
consumption
and
venous
thromboembolism
(VTE)
remains
unknown.
We
aimed
to
evaluate
the
with
different
additives
(milk
and/or
sweeteners)
incident
VTE,
modifying
effects
of
genetic
variation
in
caffeine
metabolism
on
association.
Methods
A
total
190,189
participants
complete
dietary
information
free
VTE
at
baseline
UK
Biobank
were
included.
primary
outcome
was
including
deep
vein
thrombosis
pulmonary
embolism.
Results
During
a
median
follow-up
12.1
years,
4,485
(2.4%)
developed
VTE.
Compared
non-tea
drinkers,
drinkers
who
added
neither
milk
nor
sweeteners
(hazard
ratio
[HR]:
0.85;
95%
confidence
interval
[95%
CI]:
0.76–0.94),
only
(HR:
0.86;
CI:
0.80–0.93),
both
their
0.90;
0.81–0.99)
had
lower
risk
while
those
did
not
0.94;
0.75–1.17).
Moreover,
there
an
L-shaped
relationship
among
sweeteners,
milk,
tea,
respectively.
However,
nonsignificant
found
tea.
Genetic
significantly
modify
(p-interaction
=
0.659).
Conclusion
Drinking
unsweetened
or
without
associated
no
significant
drinking
Food & Function,
Год журнала:
2024,
Номер
15(8), С. 4527 - 4537
Опубликована: Янв. 1, 2024
Artificial
sweeteners
(ASs)
have
been
widely
added
to
food
and
beverages
because
of
their
properties
low
calories
sweet
taste.
However,
whether
the
consumption
ASs
is
causally
associated
with
cancer
risk
not
clear.
Here,
we
utilized
two-sample
Mendelian
randomization
(MR)
method
study
potential
causal
association.
Genetic
variants
like
single-nucleotide
polymorphisms
(SNPs)
exposure
(AS
consumption)
were
extracted
from
a
genome-wide
association
(GWAS)
database
including
64
949
Europeans
influence
confounding
was
removed.
The
outcome
98
GWAS
data
included
several
types
cancers
lung
cancer,
colorectal
stomach
breast
so
on.
exposure-outcome
SNPs
harmonized
then
MR
analysis
performed.
inverse-variance
weighted
(IVW)
random
effects
used
as
main
analytical
accompanied
by
four
complementary
methods:
Egger,
median,
simple
mode,
mode.
Sensitivity
analyses
consisted
heterogeneity,
pleiotropy,
leave-one-out
analysis.
Our
results
demonstrated
that
coffee
had
positive
high-grade
low-grade
serous
ovarian
cancer;
tea
oral
cavity
pharyngeal
cancers,
but
negative
malignant
neoplasm
bronchus
lungs.
No
other
genetic
AS
consumption.
revealed
no
major
cancers.
Larger
studies
or
RCTs
are
needed
investigate
small
support
this
conclusion.
Plants,
Год журнала:
2023,
Номер
12(12), С. 2273 - 2273
Опубликована: Июнь 11, 2023
Obesity
is
the
most
prevalent
health
problem
in
Western
world,
with
pathological
body
weight
gain
associated
numerous
co-morbidities
that
can
be
main
cause
of
death.
There
are
several
factors
contribute
to
development
obesity,
such
as
diet,
sedentary
lifestyle,
and
genetic
make-up.
Genetic
predispositions
play
an
important
role
but
variations
alone
cannot
fully
explain
explosion
which
why
studies
have
turned
epigenetics.
The
latest
scientific
evidence
suggests
both
genetics
environmental
rise
obesity.
Certain
variables,
diet
exercise,
ability
alter
gene
expression
without
affecting
DNA
sequence,
a
phenomenon
known
Epigenetic
changes
reversible,
reversibility
makes
these
attractive
targets
for
therapeutic
interventions.
While
anti-obesity
drugs
been
proposed
this
end
recent
decades,
their
side
effects
make
them
not
very
attractive.
On
other
hand,
use
nutraceuticals
loss
increasing,
shown
some
products,
resveratrol,
curcumin,
epigallocatechin-3-gallate,
ginger,
capsaicin,
caffeine,
expression,
restoring
normal
epigenetic
profile
aiding
loss.
PLoS Medicine,
Год журнала:
2024,
Номер
21(1), С. e1004337 - e1004337
Опубликована: Янв. 23, 2024
Background
Despite
the
substantial
evidence
of
relationship
between
diet
and
mortality,
role
beverage
consumption
patterns
is
not
well
known.
The
aim
this
study
was
to
assess
association
adherence
a
Healthy
Beverage
Score
(HBS)
all-cause
mortality
in
representative
sample
Spanish
adult
population.
Methods
findings
We
conducted
an
observational
cohort
using
data
from
Study
on
Nutrition
Cardiovascular
Risk
Spain
(ENRICA),
which
included
12,161
community-dwelling
individuals
aged
≥18
years
recruited
2008
2010
followed
until
January
2022.
At
baseline,
food
collected
validated
history.
HBS
consists
7
items,
each
scored
1
4
(highest
adherence).
ranges
28
points
with
higher
score
representing
healthier
pattern.
Adherence
assigned
as
low-fat
milk,
coffee
tea,
lower
whole-fat
no
fruit
juice,
artificially
sweetened
beverages,
or
sugar-sweetened
moderate
alcohol.
Total
ascertained
by
linkage
National
Death
Index.
Statistical
analyses
were
performed
Cox
models
adjusted
for
main
confounders,
including
sociodemographic,
lifestyle,
dietary
variables,
morbidity.
After
mean
follow-up
12.5
(SD:
1.7;
range:
0.5
12.9),
total
967
deaths
occurred.
For
fully
hazard
ratio
(HR)
highest
versus
lowest
sex-specific
quartiles
0.72
(95%
confidence
interval
[0.57,
0.91],
p
linear-trend
=
0.015),
corresponding
8.3%
reduction
absolute
risk
death.
A
linear
death
observed
restricted
cubic
splines.
results
robust
sensitivity
analyses.
limitation
that
repeated
measurements
available
could
have
changed
during
follow-up.
Conclusions
In
study,
we
associated
mortality.
healthy
pattern
play
prevention
premature
Postgraduate Medical Journal,
Год журнала:
2024,
Номер
100(1186), С. 603 - 610
Опубликована: Март 23, 2024
Abstract
Objective
To
investigate
the
associations
of
tea,
coffee,
and
red
wine
intakes
with
health
risks
among
individuals
hypertension.
Methods
This
prospective
cohort
study
included
participants
hypertension
from
UK
Biobank
cohort.
Study
exposures
self-reported
wine.
The
primary
outcome
was
all-cause
mortality,
secondary
outcomes
were
cardiovascular
mortality
disease.
beverage
intake
analyzed
using
Cox
regression
models.
hazard
ratios
95%
confidence
intervals
estimated.
Results
A
total
187
708
included.
median
follow-up
period
13.8
years.
In
hypertension,
drinking
one
to
two
cups/day
coffee
or
three
four
tea
significantly
associated
lowest
risk
compared
less
than
cup/day
[hazard
ratio
for
0.943
(95%
interval,
0.908–0.979);
0.882
0.841–0.924)].
Red
inversely
risk.
Dose–response
analysis
revealed
that
high
(approximately
greater
equal
six
cups/day)
increased
disease,
but
not.
Furthermore,
replacing
plain
water
not
reduced
Replacing
other
alcoholic
beverages
also
all
outcomes.
Conclusions
These
findings
suggest
wine,
can
be
part
a
healthy
diet
hypertensive
population.
Thrombosis and Haemostasis,
Год журнала:
2024,
Номер
124(12), С. 1143 - 1151
Опубликована: Май 10, 2024
Objective
The
association
between
tea
consumption
and
venous
thromboembolism
(VTE)
remains
unknown.
We
aimed
to
evaluate
the
with
different
additives
(milk
and/or
sweeteners)
incident
VTE,
modifying
effects
of
genetic
variation
in
caffeine
metabolism
on
association.
Methods
A
total
190,189
participants
complete
dietary
information
free
VTE
at
baseline
UK
Biobank
were
included.
primary
outcome
was
including
deep
vein
thrombosis
pulmonary
embolism.
Results
During
a
median
follow-up
12.1
years,
4,485
(2.4%)
developed
VTE.
Compared
non-tea
drinkers,
drinkers
who
added
neither
milk
nor
sweeteners
(hazard
ratio
[HR]:
0.85;
95%
confidence
interval
[95%
CI]:
0.76–0.94),
only
(HR:
0.86;
CI:
0.80–0.93),
both
their
0.90;
0.81–0.99)
had
lower
risk
while
those
did
not
0.94;
0.75–1.17).
Moreover,
there
an
L-shaped
relationship
among
sweeteners,
milk,
tea,
respectively.
However,
nonsignificant
found
tea.
Genetic
significantly
modify
(p-interaction
=
0.659).
Conclusion
Drinking
unsweetened
or
without
associated
no
significant
drinking
