Time‐restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial

Obesity, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted (UE) on weight, body composition, intake, glycemic measures, metabolic flexibility. In this 12-week randomized-controlled trial, we measured (primary outcome), composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), intake (24-h recall), flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), measures (hemoglobin A1c, clamp, continuous glucose monitoring). Of 88 enrolled participants, 81 (92%) completed trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m2; 54.5% female, 84.1% White). Final windows were 9.8 h (95% CI: 9.0 to 10.6) for TRE, 12.9 11.9 13.9) CR, 11.8 11.0 12.7) UE. Compared with UE (n = 29), changes -1.4 kg -4.5 1.7; p 0.53) TRE 30) -2.5 -5.8 0.8; 0.18) CR 29). showed lower than (-0.041 [95% -0.080 -0.002]). Weight, similar among groups. Eating window reduction correlated decreased visceral fat. a intervention, did not lead significant in average or

Язык: Английский

---

Can cardiovascular health and its modifiable healthy lifestyle offset the increased risk of all-cause and cardiovascular deaths associated with insulin resistance?

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 10, 2025

Insulin resistance(IR) is associated with an increased risk of all-cause and cardiovascular death, modifiable healthy lifestyles play active role in the improvement IR reduction death. Whether health (CVH) within it can attenuate or even offset heightened perils both deaths insulin resistance remains unclear. The study encompassed 14,172 participants from 2005–2018 NHANES programme. was evaluated using TyG index, TyG-WC, TyG-WHtR, while CVH assessed employing LE8 score, addition to LE4 index redefined according four behaviours. Weighted multifactor Cox regression models were used assess association mortality, dose-response relationships restricted cubic spline. Furthermore, subjects grouped scores, generalised linear estimate weighted mortality death for each group calculate absolute difference. Finally, predicted probability as a function computed, complex relationship between three visualised two-dimensional scatter plots three-dimensional surface plots. Among included study, 1534 occurred over mean follow-up period 7.6 years (382 these due causes). analysis indicated that elevated TyG-WC TyG-WHtR correlated greater likelihood all causes events, whereas inversely risks. Additional stratification revealed notable events improved, irrespective presence resistance. Additionally, high but moderate did not have significantly risks compared those low Stratified 3D reduced resistance-related reductions observed at higher levels. In this cohort improving behaviors deaths. Maintaining levels (LE8 ≥ 50) could caused by

Язык: Английский

---

Interaction of Triglyceride-Glucose Index and Metabolic Syndrome with Risk of Incident Stroke Among Middle-Aged and Older Chinese Adults

Journal of Multidisciplinary Healthcare, Год журнала: 2025, Номер Volume 18, С. 947 - 955

Опубликована: Фев. 1, 2025

The triglyceride-glucose (TyG) index, a reliable surrogate marker of insulin resistance, has been shown as an independent risk factor for stroke. Still, the interaction between metabolic syndrome (MetS) and TyG index in determining stroke remains to be clarified, which may help optimize prevention strategies. This study aims explore whether influences association A total 7770 middle-aged older participants free at baseline were enrolled from China Health Retirement Longitudinal Study. was calculated ln (triglyceride [mg/dL] × fasting glucose [mg/dL]/2). MetS defined following modified International Diabetes Federation criteria. outcome self-reported, physician-diagnosed, incident during follow-up. Cox proportional hazard models used examine associations 568 (7.3%) cases occurred after median observation time 7.0 years. After adjusting potential confounders, higher level associated with increased (hazard ratio (HR) 1.19, 95% CI 1.05-1.33, P = 0.016). significant without (HR 1.69, 1.40-1.97, < 0.001), but not those 1.05, 0.88-1.21, 0.599). on (P 0.004). influenced among Chinese adults. more effective stratification populations compared MetS.

Язык: Английский

---

JCL Rountable: Dietary Recommendations and Intermittent Fasting and Time-Restricted Eating

Journal of clinical lipidology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

---

Correlation study and full management of metabolic syndrome and sperm DNA fragmentation index, a regional multicentre prospective long term follow-up study from Anhui, China

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Май 2, 2025

Objective To investigate the correlation between Metabolic syndrome (Mets) and Sperm DNA fragmentation index (DFI) in men of reproductive age, to summarise Mets metabolic component health management model men. Methods The Male Reproductive Health Follow-up Database Bozhou City, Anhui Province, China (2020–2024) included study 1,008 outpatient cases with age,in which normal sperm DFI was Control group (n = 858) abnormal Observation 150), general data, endocrine related indicators, indicators fertility assessment were analysed both groups, followed up. Spearman rank coefficient used for analysis, segmented package threshold Bootstrap sampling method Bayesian mediation effect test analysis. Univariate-multivariate logistic regression analyses performed build a predictive using R Programming Language (4.42), plot Nomogram, Calibration Curve, Decision Curve Analysis (DCA) Clinical impact curve (CIC) assess consistency predicted probability actual occurrence probability, as well evaluate practicality applicability clinical decision-making. Results Intergroup comparison observation control groups this showed no statistical difference two terms baseline information ( P &gt; 0.05). However, there MetS scores &lt; 0.001). One-way ANOVA statistically significant 0.021), two-way comparisons 0–4 points There moderate-strength positive score by Spearman’s analysis (r 0.475, Overall, positively associated [OR (95%CI):1.09 (1.07–1.11)] when DFI&lt; 32.26 (95%CI): 1.15 (1.12–1.19)]. In overall association adverse maternity outcomes (OR 1.50, 95% CI: 1.01–2.22, 0.045). subgroup, ≤15 &gt;30 (15: OR 2.51, 95%CI: 1.01–6.22, 0.047; &gt;30:OR 2.94, 1.19–7.22, 0.019), subgroup age years 1.94, 1.13–3.33, 0.016). results mediated pathway that obesity hyperlipidaemia lead abnormalities, indirectly contribute outcomes, but it has not been proven abnormalities outcomes. multifactorial varicocele 1.975), 2.296), 2.422), Low-HDL 3.654) independent risk factors DFI. And effective interventions could significantly reduce values validated show efficacy benefit. Conclusion may indices, turn suggests due be factor male infertility spousal maternity, are necessary urgent. This is part Regional Fertility Survey Phase I (2020–2024).

Язык: Английский

---

Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus

Nature Reviews Endocrinology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Язык: Английский

---

Research hotspots and trends in diabetes and insulin resistance: a bibliometric analysis

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Дек. 16, 2024

Many previous studies explored the relationship between diabetes and insulin resistance (IR); however, addressing research gap where no bibliometric analysis had been conducted to summarize analyze these publications, we will undertake a comprehensive investigate current status emerging trends in publications examining association IR.

Язык: Английский

---