Optogenetics: 10 years of microbial opsins in neuroscience

Nature Neuroscience, Год журнала: 2015, Номер 18(9), С. 1213 - 1225

Опубликована: Авг. 26, 2015

Язык: Английский

---

Anxiety Cells in a Hippocampal-Hypothalamic Circuit

Neuron, Год журнала: 2018, Номер 97(3), С. 670 - 683.e6

Опубликована: Янв. 31, 2018

Язык: Английский

---

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior

The International Journal of Neuropsychopharmacology, Год журнала: 2016, Номер 19(8), С. pyw020 - pyw020

Опубликована: Фев. 23, 2016

There is a growing recognition of the importance commensal intestinal microbiota in development and later function central nervous system. Research using germ-free mice (mice raised without any exposure to microorganisms) has provided some most persuasive evidence for role these bacteria gut-brain signalling. Key findings show that necessary normal stress responsivity, anxiety-like behaviors, sociability, cognition. Furthermore, maintains system homeostasis by regulating immune blood brain barrier integrity. Studies have also found gut influences neurotransmitter, synaptic, neurotrophic signalling systems neurogenesis. The principle advantage mouse model proof-of-principle studies complete or defined consortiums can be introduced at various developmental time points. However, upbringing induce permanent neurodevelopmental deficits may deem unsuitable specific scientific queries do not involve early-life microbial deficiency. As such, alternatives complementary strategies are warranted include antibiotic treatment create microbiota-deficient animals distinct points across lifespan. Increasing our understanding impact on behavior potential inform novel management stress-related gastrointestinal neuropsychiatric disorders.

Язык: Английский

---

Calcium Signaling and Cardiac Arrhythmias

Circulation Research, Год журнала: 2017, Номер 120(12), С. 1969 - 1993

Опубликована: Июнь 8, 2017

There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca

Язык: Английский

---

Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

Cell, Год журнала: 2015, Номер 162(3), С. 662 - 674

Опубликована: Июль 1, 2015

Язык: Английский

---

A synaptic threshold mechanism for computing escape decisions

Nature, Год журнала: 2018, Номер 558(7711), С. 590 - 594

Опубликована: Июнь 1, 2018

Язык: Английский

---

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

Science, Год журнала: 2018, Номер 360(6390), С. 800 - 805

Опубликована: Апрель 5, 2018

Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology disease. We combined SLAM-seq [thiol(SH)-linked alkylation for the metabolic sequencing RNA], a method quantification newly synthesized messenger RNAs (mRNAs), with pharmacological chemical-genetic perturbation order define functions two transcriptional hubs cancer, BRD4 MYC, interrogate responses BET bromodomain inhibitors (BETis). found that acts as general coactivator RNA polymerase II-dependent transcription, which broadly repressed upon high-dose BETi treatment. At doses triggering selective effects leukemia, BETis deregulate small set hypersensitive including MYC. In contrast BRD4, MYC primarily activator controlling processes such ribosome biogenesis de novo purine synthesis. Our study establishes simple scalable strategy identify any gene or pathway.

Язык: Английский

---

Neurobehavioral perspectives on the distinction between fear and anxiety

Learning & Memory, Год журнала: 2015, Номер 22(9), С. 417 - 425

Опубликована: Авг. 18, 2015

In this review, we discuss the usefulness of distinction between fear and anxiety. The clinical use labels is ambiguous, often defining one in terms other. We first consider what a useful, objective, scientifically valid definition would entail then evaluate several fear/anxiety distinctions that have been made neurobiological literature. A strong should specify difference conditions lead to versus Additionally, anxiety generate distinct sets behaviors. Ideally, two states be supported by distinguishable neuroanatomical circuits. Such conceptualization consistent with National Institute Mental Health's Research Domain Criteria (RDoc). majority approaches fail differentiate behavior, using exact same behavioral measures as indicators. Of do, only Predatory Imminence Theory provides both cause effect. Indeed, approach ready anxiety, fear, panic antecedent response selection rules. it appeals neural circuits these modes action.

Язык: Английский

---

Circuit modules linking internal states and social behaviour in flies and mice

Nature reviews. Neuroscience, Год журнала: 2016, Номер 17(11), С. 692 - 704

Опубликована: Окт. 18, 2016

Язык: Английский

---

Comparing nonpharmaceutical interventions for containing emerging epidemics

Proceedings of the National Academy of Sciences, Год журнала: 2017, Номер 114(15), С. 4023 - 4028

Опубликована: Март 28, 2017

Strategies for containing an emerging infectious disease outbreak must be nonpharmaceutical when drugs or vaccines the pathogen do not yet exist are unavailable. The success of these strategies will depend on only effectiveness isolation measures but also epidemiological characteristics infection. However, there is currently no systematic framework to assess relationship between different containment and natural history dynamics pathogen. Here, we compare quarantine symptom monitoring, implemented via contact tracing, in controlling epidemics using agent-based branching model. We examine epidemic symptoms infectiousness seven case-study diseases with diverse histories, including Ebola, influenza A, severe acute respiratory syndrome (SARS). show that comparative monitoring depends critically disease, its inherent transmissibility, intervention feasibility particular healthcare setting. benefit over generally maximized fast-course diseases, conditions under which alone can control certain outbreaks. This quantitative guide policymakers how best use interventions prioritize research during

Язык: Английский

---