Loss of XIST lncRNA unlocks stemness and cellular plasticity in ovarian cancer DOI Creative Commons
Ikrame Naciri,

Minzhi Liang,

Ying Yang

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(47)

Опубликована: Ноя. 15, 2024

Plasticity, a key hallmark of cancer, enables cells to transition into different states, driving tumor heterogeneity. This cellular plasticity is associated with cancer progression, treatment resistance, and relapse. Cancer stem (CSCs) play central role in this process, yet the molecular factors underlying cell stemness remain poorly understood. In study, we explored XIST (X-inactive specific transcript) long noncoding RNA ovarian through silico vitro analyses. We found that significantly down-regulated tumors, low expression linked higher index lower overall survival. Knocking down enhanced stemness, particularly increasing mesenchymal-like CSCs, under hypoxic conditions, it promoted epithelial-like CSC markers. Our findings suggest loss leads enrichment pointing potential therapeutic targets for patients expression.

Язык: Английский

Loss of XIST lncRNA unlocks stemness and cellular plasticity in ovarian cancer DOI Creative Commons
Ikrame Naciri,

Minzhi Liang,

Ying Yang

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(47)

Опубликована: Ноя. 15, 2024

Plasticity, a key hallmark of cancer, enables cells to transition into different states, driving tumor heterogeneity. This cellular plasticity is associated with cancer progression, treatment resistance, and relapse. Cancer stem (CSCs) play central role in this process, yet the molecular factors underlying cell stemness remain poorly understood. In study, we explored XIST (X-inactive specific transcript) long noncoding RNA ovarian through silico vitro analyses. We found that significantly down-regulated tumors, low expression linked higher index lower overall survival. Knocking down enhanced stemness, particularly increasing mesenchymal-like CSCs, under hypoxic conditions, it promoted epithelial-like CSC markers. Our findings suggest loss leads enrichment pointing potential therapeutic targets for patients expression.

Язык: Английский

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